|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C显示文摘Hepatitis C is the most common indication for orthotopic liver transplantation in the United States. Unfortunately, hepatitis C recurs universally in the transplanted liver and is the major cause of decreased graft and patient survival. The combination therapy of interferon and ribavirin has been shown to be the most effective therapy for recurrent hepatitis C. However, pre-and post-transplant hypersplenism often precludes patients from receiving the antiviral therapy. Splenectomy and partial splenic embolization are the two invasive modalities that can correct the cytopenia associated with hypersplenism. In this report we review the two treatment options, their associated outcomes and complications. | Lena Sibulesky Justin H Nguyen Ricardo Paz-Fumagalli C Burcin Taner Rolland C Dickson | 2009 | World Journal of Gastroenterology2009，15，40： | 5 |
| 2 | Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells显示文摘AIM To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeuticallyapproach for cholangiocellular cancer treatment. METHODS As most cholangiocarcinomas are chemotherapyresistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma(CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases(PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727(Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and q RT-PCR were used to measure expression levels of apoptosis-related molecules Bax and Bcl-2. RESULTS The cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by co-treatment with BI6727.CONCLUSION In conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect. | Svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas | 2017 | World Journal of Gastroenterology2017，23，22： | 5 |
| 3 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Leandro Vinícius Alves Gurgel Júlio César Perin de Melo Jorge Carvalho de Lena Laurent Frédéric Gil | 2009 | Bioresource Technology2009，，13： | 1 |
| 4 | Lung macrophages and dendritic cells express HLA - G molecules in pulmonary diseases 显示文摘 | Pangault C Le Friec G Caulet - Maugendre S Lena H Amiot L Guilloux V Onno M Fauchet R | 2002 | Hum Immunol2002，63，2： | 1 |
| 5 | Identification of four classes of brain nicotinic receptors using b2 mutant mice显示文摘 | ZOLI M LENA C PICCOPTTO M R | 1998 | JNeurosci1998，18，： | 1 |
| 6 | Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain显示文摘 | POCCIOTFO M R ZOLI M LENA C | 1995 | Nature1995，374，： | 1 |
| 7 | Increase in macrophage elastase(MMP-12)in lungs from patients with chronic obstructive pulmonary disease显示文摘 | MOLET S BELLEGUIC C LENA H | 2005 | Inflamm Res2005，54，1： | 1 |
| 8 | Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats显示文摘 | Amanda Miller Vibhas Mujumdar Lena Palmer John D Bower Suresh C Tyagi | 2002 | American Journal of Hypertension2002，，2： | 1 |
| 9 | Outcomes following liver transplantation in intensive care unit patients显示文摘AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient survival.METHODS:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December 2010.RESULTS:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and norepinephrine.Sixteen ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to transplantation.Twenty-five ICU patients (64%) required dialysis preoperatively.At 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU patients.Patient survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU patients.When formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable analysis.These findings were consistent in multivariable analysis.Although not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (RR:4.19,P=0.033).Graft survival and patient survival were not significantly worse for patients on mechanical ventilation (RR:0.91,P=0.88 in graft loss;RR:0.69,P=0.56 in death) or patients on vasopressors (RR:1.06,P=0.93 in graft loss;RR:1.24,P=0.74 in death) immediately prior to LT.Trends toward lower graft survival and patient survival were observed for patients on dialysis immediately before LT,however these findings did not approach statistical significance (RR:1.70,P=0.43 in graft loss;RR:1.46,P=0.58 in death).CONCLUSION:Although ICU patients when compared to non-ICU patients have lower survivals,outcomes are still acceptable.Pre-transplant ventilation,hemodialysis,and vasopressors were not associated with adverse outcomes. | Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen | 2013 | World Journal of Hepatology2013，5，1： | 1 |
| 10 | Adsorption of chromium (VI) ion from aqueous solution by succinylated mercerized cellulose functionalized with quaternary ammonium groups显示文摘 | Gurgel L V A de Melo J C P de Lena J C | 2009 | Bioresource Technology2009，100，13： | 1 |
| 11 | Preoperative stress conditioning prevents paralysis after experimental aortic surgery:increased heat shock protein content is associated with ischemic tolerance of the spinal cord显示文摘 | Perdrizet GA Lena C J Shapiro DS | 2002 | J Thorac Cardiovasc Surg2002，124，1： | 1 |
| 12 | Intracranial meningiomas in children: review of 29 cases显示文摘 | Erdincler P Lena G Kuday C | 1998 | Surg Neurol1998，49，： | 1 |
| 13 | Allosteric nicotinic receptors, human pathologies显示文摘 | Lena C Changeux JP | 1998 | J Physiol Paris1998，92，2： | 1 |
| 14 | Quality of life and cost-effectiveness of acupuncture treatment in patients with osteoarthritis pain显示文摘 | REINHOLD T WILL C M LENA S | 2008 | Eur J Health Econ2008，9，3： | 1 |
| 15 | Increase in maerophage elastase( MMP - 12) in lungs from patients with chronic obstructive pulmonary disease显示文摘 | Molets S Belleguic C Lena H | 2004 | Inflamm Res2004，54，1： | 1 |
| 16 | On the definition and modelling of streamflow drought duration and deficit volume 显示文摘 | LENA M T HENRIK M BENTE C | 1997 | Hydrological Sciences - Journal - des Sciences Hydrologiques1997，42，1： | 1 |
| 17 | Principal component analysis as an exploration tool for kinetic modeling of food quality: A case study of a dried apple cluster snack 显示文摘 | JORGE S ANDRES C LENA G | 2013 | Journal of Food Engineering2013，119，： | 1 |
| 18 | Mechanisms of lead, copper, and zinc retention by phosphate rock 显示文摘 | Xinde C Lena Q M Dean R R | 2004 | Environmental pollution2004，131，3： | 1 |
| 19 | Proteome map of normal rat retina and comparison with the pro- teome of diabetic rat retina: new insight in the pathogenesis of diabetic retinopathy 显示文摘 | QUIN G G LENA C BILLSON F A GILLIES M C | 2007 | Proteomics2007，7，15： | 1 |
| 20 | 显示文摘 | Patermarakis G Lenas P Karavassilis C | 1991 | Electrochim Acta1991，36，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员