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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | The age of multilevel converters arrives显示文摘 | L G Franquelo J Rodriguez J I Leon S Kouro R Portillo and M A M Prats | | 0，，02： | 1 |
| 3 | Genome-wide atlas of transcription through maize development显示文摘 | Sekhon R S Lin H Childs K L Hirsch C N Buell C R de Leon N Kaeppler S M | 2011 | The Plant Journal2011，66，4： | 1 |
| 4 | Time course of cytokine,corticosterone,and tissue injury responses in mice during heat strain recovery显示文摘 | LEON L R BLAHA M D DUBOSE D A | 2006 | J Appl Physiol2006，100，4： | 1 |
| 5 | Human challenges in polar and space enviroument显示文摘 | SANDAL G M LEON G R PALINKAS L A | 2006 | Reviews in Environmental Science and Bio/technology2006，，5： | 1 |
| 6 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 7 | Heat transfer and pressure drop characteristic of angled spiraling tape inserts in a heat exchanger annulus显示文摘 | Hennie C Leon L Josua P M | 2003 | Heat Transfer Engineering2003，24，6： | 1 |
| 8 | A structure-based approach to retinoid X receptor-alpha inhibition显示文摘 | Stebbins J L Jung D Leone M | 2006 | J Biol Chem2006，281，16： | 1 |
| 9 | Catalyst composition optimization for the reduction of sulfur dioxide by carbon monoxide显示文摘 | Happel J Leon A L Hnatow M A | 1977 | Ind Eng Chem Prod Res Dev1977，16，2： | 1 |
| 10 | Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease显示文摘 | Mosconi L de Leon M Murray J | 2011 | J Alzheimers Dis2011，27，： | 1 |
| 11 | Mechanistic studies on Lewis acid catalyzed Biginelli reactions in ionic liquids: Evidence for the reac- tive intermediates and the role of the reagents 显示文摘 | Ramos L M Ponce de Leon Y Tobio A Y dos Santos M R | 2012 | Journal of Organic Chemistry2012，77，10： | 1 |
| 12 | Hepatic involvement in larva migrans of Toxocara canis : report of a case with pathological and radiological findings 显示文摘 | Leone N Baronio M Todros L | 2006 | Digestive and Liver Disease2006，38，7： | 1 |
| 13 | Prediction of phosphorus mobilisation in inundated floodplain soils 显示文摘 | ROOS L LEON P M LAMERS | 2008 | Environ Pollut2008，156，： | 1 |
| 14 | A randomized comparison of coronary stent placement and balloon angioplasty in the treatment of coronary artery disease显示文摘 | Fischman D L Leon M B Balm D S | 1994 | N Engl J Meal1994，331，： | 1 |
| 15 | Constitutive arginine-dependent nitric oxide synthase activity in different organs of pea seedlings during plant development显示文摘 | CORPAS F J BARROSO J B CARRERAS A VALDERRAMA R PALMA J M LEON A M SANDALIO L M DEL RIO L A | 2006 | Planta2006，224，2： | 1 |
| 16 | Exposure to extremely low-frequency (50 Hz) electromagnetic fields enhances adult hippocampal neurogenesis in C57BL/6 mice显示文摘 | CUCCURAZZU B LEONE L PODDA M V | 2010 | Exp Neurol2010，226，1： | 1 |
| 17 | SpatiotemporM evolution of ventneularfibfillation显示文摘 | WITKOWSKI F X J LEON L PENKOSKE P A et M | 1998 | Nature1998，392，： | 1 |
| 18 | The electrochemical evaluation of a Zr-based bulk metallic glass in a phosphate-buffered saline electrolyte显示文摘 | Morrison M L Buchanan R A Leon R V | 2005 | Journal of Biomedical Materials Research Part A2005，74，3： | 1 |
| 19 | The effect of microstructure on abrasive wear of hardfacing alloys显示文摘 | Buchely M F Gutierrez J C Leon L M | 2005 | Wear2005，259，1： | 1 |
| 20 | The electrochemical evaluation of a Zr-based bulk metallic glass in a phosphate-buffered saline electrolyte 显示文摘 | Morrison M L Buchanan R A Leon R V | 2005 | J Biomed Mater Res2005，74，3： | 1 |
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