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86篇 您的检索式:作者名="LEONG C P"
    题名 作者 年代 出处 被引量
1miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus显示文摘AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium.Cameron M Smith David I Watson Mary P Leong George C Mayne Michael Z Michael Bas PL Wijnhoven Damian J Hussey 2011World Journal of Gastroenterology2011,17,8:13
2On the reconfiguration of de- gradable VLSI/WSI arrays显示文摘Low C P Leong H W 1997IEEE Trans Comput- er-Aided Design of Integrated Circuits and Systems1997,16,10:1
3Receptor- Mediated Self - Assembly of Multi - Component Magnetic Nanowires显示文摘Salem A K Chao J Leong K W Searson P C 2004Advanced Materials2004,16,3:1
4The increasing burden of atrial fibrillation compared with heart failure and myocardialinfarction: a 15-year study of all hospitalizations in Australia显示文摘Wong C X Brooks A G Leong D P 2012Archives of Internal Medicine2012,172,9:1
5The p63/p73 network mediates chemosensitivity tocisplatin in a biologically defined subset of primarybreast cancers 显示文摘LEONG C 0 VIDNONIC N DEYOUNG M P 2007J Clin Invest2007,117,5:1
6Life cycle assessment study of solar PV systems:an example of a 27 kWp distributed solar PV system in Singapore显示文摘Kannan R Leong K C Osman R Ho H K Tso C P 0,,05:1
7Trends in laryngo- pharyngeal reflux: a British ENT survey显示文摘KARKOS P D BENTON J LEONG S C 2007Eur Arch Otorhinolaryn- gel2007,264,5:1
8The traction and cervical intervertebral separation显示文摘WONG A K LEONG C P CHEN C M 1998spine1998,17,:1
9Alerations in the cardiopulmonary effects and pharmacokinetics of a bisphosphonate drug by a cytochrome P-450 inhibitor in conscious rats 显示文摘LEONG B K SABAITIS C P ROP D A 1997J Appl Toxicol1997,17,5:1
10A comparison of aesthetic proportions between the Oriental and Caucasian nose显示文摘LEONG S C WHITE P S 2004Clin Otol2004,29,6:1
11Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function显示文摘Sakanaka C Leong P Xu L 1999Proe Natl Acad Sci USA1999,96,12:1
12Inclusion Complexation and Formation of Polypseudorotaxanes between Polyand Cyclodextrins显示文摘Li J Li X Toh K C Ni X P Zhou Z H Leong K W 2001Macromolecules2001,34,:1
13Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats显示文摘LEONG B K COOMBS J K SABAITIS C P 1998J Appl Tnxicol1998,18,:1
14On the-fly TCP path selection algorithm in access link load balaneing显示文摘LIN Y D TSAO S C LEONG U P 2007Computer Communications2007,30,2:1
15Spectrophotometic determination ascorbic acid in the phamecy 显示文摘 Leong P C 1964Analyst1964,89,:1
16En- doscopic control of thesphenopalatine artery for epip- staxis: long-term results 显示文摘ABDELKADER M LEONG S C WHITE P S 2007J Laryngol Otol2007,121,:1
17Why genetic and disease-specific quality-of-life instruments should be used together for the evaluation of patients with persistent allergic rhinitis显示文摘Leong K P Yeak S C Saumjen A S 2005Clin Exp Allergy2005,35,3:1
18Single laboratory validation of a method for the determination of bisphenol A,bisphenol A diglycidyl ether and its derivatives in canned foods by reversed-phase liquid chromatography显示文摘Sun C Leong L P Barlow P J 2006Journal of Chromatography A2006,1129,1:1
19Prognostic value of bone marrow angiogenesis in multiple myeloma显示文摘Rajkumar S V Leong T Roche P C 2000Clin Cancer Res2000,6,8:1
20Best diagnostic criterion in high-resolution ultrasonography for carpal tunnel syndrome显示文摘Wang L Y Leong C P Yc H 2008Chang Gung Med J2008,31,5:1
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