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30篇 您的检索式：作者名="LEOPOLD D J"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Host innate im- munite responses to sepsis显示文摘	Wiersanga W J Leopold S J Cranendonk D R	2014	Virulence2014，5，1：	1
3	Phytochelatins and heavy metal tolerance 显示文摘	Leopold I Schmidt J Neumarm D	1999	Phytochemistry1999，50，：	1
4	On the mechanism of aging in soybean seeds显示文摘	PARRISH D J LEOPOLD A C	1978	Plant Physiol1978，61，3：	1
5	Use of habitat guilds of fish to determine instream flow requirements显示文摘	LEOPOLD L B ORTH D J	1998	North Am J Fish Manage1998，8，：	1
6	On the mechanism of aging in Soy- bean seeds显示文摘	Parrish D J Leopold A C		0，，：	1
7	Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo显示文摘	SEBOLT - LEOPOLD J S DUDLEY D T HERRERA LEOPOLD	1999	Nat Med1999，5，7：	1
8	Host innate immune responses to sepsis 显示文摘	Wiersinga W J Leopold S J Cranendonk D R	2014	Virulence2014，5，1：	1
9	Habitat sampling and selection by female wild turkey during preincubation显示文摘	Chamberlain M J Leopold B D	2000	Wilson Bull2000，112，3：	1
10	On the mechanism of aging in soybeans显示文摘	PARRISH D J LEOPOLD A C	1978	Plant Physiology1978，61，：	1
11	查看详情显示文摘	Mackenzie K D Eggert J R Leopold D J Li Y M Lin S Paul W		0，，：	1
12	Using electroporation and a slot cuvette to deliver plasmid DNA to insect embryos显示文摘	Leopold R A Hughes K J Devault D	1996	Genetic Analysis/Biomolecular Engineering1996，，12：	1
13	Conducting thermoset polymers:A comparative study of Schiff base precursors with different end groups显示文摘	BROWN I M LEOPOLD D J MOHITE S	1995	Synthetic Metals1995，72，：	1
14	Chilling stress to soybeans during imhibition显示文摘	BramLage W J Leopold A C Parrish D J	1978	Plant Physiol1978，61，：	1
15	High glucose inhibits glueose-6-phosphate dehydrogen ase,leading to increased oxidative stress and 13-cell apoptosis显示文摘	Zhang Z Liew C W Handy D E Zhang Y Leopold J A Hu J	2010	FASEB J2010，24，：	1
16	Understory re- sponse to spring time prescribed fire in two New York transition oak forests 显示文摘	McGee G G Leopold D J Nyland R D	1995	Forest Ecology and Manage- ment1995，76，：	1
17	显示文摘	LEOPOLD D G ALMLC)F J L1NEBERGER W	1988	J Chem Phys1988，88，6：	1
18	On the Mechanism of Ageing in Soybean Seeds显示文摘	PARRISH D J LEOPOLD A C	1978	Plant Physiol1978，61，：	1
19	On the Mechanism of Aging in Soybean Seeds 显示文摘	PARRISH D J LEOPOLD A C	1978	Plant Physiology1978，61，3：	1
20	Watershed liming and pit and mound topography effects on seed banks in the Adirondacks, New York显示文摘	Smallidge P C Leopold D J	1984	Forest Ecology and Management1984，72，：	1

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