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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Alpha fetoprotein,ultrasound,computerized tomography and magnetic resonance imaging for detection of hepatocellular carcinoma in patients with advanced cirrhosis显示文摘 | SNOWBERGER N CHINNAKOTLA S LEPE R M | | 0，，09： | 1 |
| 3 | Ethyl carbamate production by selected yeasts and lactic acid bacteria in red wine 显示文摘 | UTHURRY CA LEPE J A S LOMBARDERO J | 2006 | Food Chem2006，94，2： | 1 |
| 4 | Quasinormal modes of the extremal BTZ black hole显示文摘 | CRISOSTOMO J LEPE S SAAVEDRA J | 2004 | Class Quant Grav2004，21，： | 1 |
| 5 | Incidence of nitrogenous compounds of must on ethyl carbamate formation induced by lacticacid bacteria显示文摘 | Lepe J A S Uthurry C A | 2007 | Joumal International Des Sciences De La Vigne Et Du Vin2007，41，4： | 1 |
| 6 | Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact dermatitis 显示文摘 | Kaur S Zilmer K Leping V | 2012 | Dermatology2012，225，1： | 1 |
| 7 | Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact dermatitis 显示文摘 | Kaur S Zilmer K Leping V | 2012 | Dermatology2012，225，1： | 1 |
| 8 | Absence of adult dental anomalies in familial hypophosphatasia显示文摘 | Lepe X Rothwell BR Banich S | 1997 | J Perio Res1997，32，4： | 1 |
| 9 | Viscous dark energy and phantom evolution 显示文摘 | Cataldo M Cruz N Lepe S | 2005 | Phys Lett B2005，619，： | 1 |
| 10 | Ethyl car-bamate production by selected yeasts and lactic acid bacte-ria in red wine显示文摘 | Uthurry C A Lepe J A S LombarderoJ | 2006 | Food Chem2006，94，2： | 1 |
| 11 | Incidence of nitrogenous com-pounds of must on ethyl carbamate formation induced by lactic acid bacteria显示文摘 | Lepe J A S Uthurry C A | 2007 | J Int Des Sci De La Vigne Et Du Vin2007，41，4： | 1 |
| 12 | Comparative study of systemic inflammatory responses in psoriasis vulgaris and mild to moderate allergic contact dermatitis显示文摘 | Kaur S Zilmer K Leping V | 2012 | Dermatology2012，225，1： | 1 |
| 13 | Worldwide emergence of extensively drug-resistant tuber culosis显示文摘 | Shah NS Wright A Bai GH Barrera L Boulahbal F Martin-Casabona N Drobniewski F Gilpin C Havelkova M Lepe R Lumb R Metchock B Portaels F Rodrigues MF Rusch-Gerdes S Van Deun A Vincent V Laserson K Wells C Cegiels ki JP | 2007 | Emerg Infect Dis2007，13，3： | 1 |
| 14 | The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis 显示文摘 | Kaur S Zilmer K Leping V | 2011 | J Eur Acad Dermatol Venereol2011，25，11： | 1 |
| 15 | Serum methylglyoxal level and its association with oxidative stress and disease severity in patients with psoriasis显示文摘 | Kaur S Zilmer K Leping V | 2013 | Arch Demlatol Res2013，305，6： | 1 |
| 16 | Alpha fe- toprotein, ultrasound, computerized tomography and mag- netic resonance imaging for detection of hepatoceUular carci- noma in patients with advanced cirrhosis 显示文摘 | Snowberger N Chinnakotla S Lepe R M | 2007 | Aliment Phar- macol Ther2007，26，9： | 1 |
| 17 | Comparative study of systemic inflam- matory responses in psoriasis vulgaris and mild to moderate allergic con- tact dermatitis显示文摘 | Kaur S Zilmer K Leping V | 2012 | Dermatology2012，225，1： | 1 |
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