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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Pancreatic cancer: Are 'liquid biopsies' ready for prime-time?显示文摘Pancreatic cancer is a disease that carries a poor prognosis. Accurate tissue diagnosis is required. Tumours contain a high content of stromal tissue and therefore biopsies may be inconclusive. Circulating tumour cells(CTCs) have been investigated as a potential 'liquid biopsy' in several malignancies and have proven to be of prognostic value in breast, prostate and colorectal cancers. They have been detected in patients with localised and metastatic pancreatic cancer with sensitivities ranging from 38%-100% using a variety of platforms. Circulating tumour DNA(ct DNA) has also been detected in pancreas cancer with a sensitivity ranging from 26%-100% in studies across different platforms and using different genetic markers. However, there is no clear consensus on which platform is the most effective for detection, nor which genetic markers are the most useful to use. Potential roles of liquid biopsies include diagnosis, screening, guiding therapies and prognosis. The presence of CTCs or ct DNA has been shown to be of prognostic value both at diagnosis and after treatment in patients with pancreatic cancer. However, more prospective studies are required before this promising technology is ready for adoption into routine clinical practice. | Alexandra R Lewis Juan W Valle Mairead G Mc Namara | 2016 | World Journal of Gastroenterology2016，22，32： | 5 |
| 3 | 轿车柴油机进气门与座圈磨损机理的研究显示文摘采用台式试验装置来研究轿车柴油机进气门与座圈的磨损机理,所用的台式试验装置按模拟进气门与座圈的负荷环境和接触条件而设计的。研究表明进气门与座圈的磨损问题包括两种不同的机理:气门关闭时的落座冲击和燃烧压力作用下气门在座圈上的滑动。研究表明,磨损的主要机理与各种关键的工作状态有关,例如气门的关闭速度、燃烧负荷、气门相对气门座的不对中性以及气门和座圈的材料选择等。 | Lewis R Dwyer-Joyce R S Josey G 史大德 | 2000 | 国外内燃机2000，，4： | 2 |
| 4 | Effect of two opposing changes in photoperiod upon age at first egg and related traits in layer - hybrid pullets 显示文摘 | Lewis P D Perry G C Morris T R | 2003 | Journal of Agricultural Science Cambridge2003，140，： | 1 |
| 5 | Thiazolo pyrimidines: 1 : synthesis and anti-human cytomegalovirus (HCMV) activity in-vitro of certain alkyl derivatives显示文摘 | Lewis A F Revankar G R Fennewald S M | 1995 | J Heterocycl Chem1995，32，20： | 1 |
| 6 | Molecular basis of calcium sig-naling in lymphocytes:STIM and ORAI显示文摘 | Hogan P G Lewis R S Rao A | 2010 | Annu Rev Immuno2010，28，： | 1 |
| 7 | A model for predicting the age at sexual maturity for growing pullets of layer strains given a single change in photoperiod 显示文摘 | Lewis P D Morris T R Perry G C | 2002 | Journal of Agricultural Science Cambridge2002，130，： | 1 |
| 8 | Vertical nitrite fluxes in the oligotrophic ocean显示文摘 | Lewis M R Harrison W G Oakey N S | 1986 | Science1986，234，： | 1 |
| 9 | Effect of constant and of changing photoperiod on plasma LH and FSH concentrations and age at first egg in layer strains of domestic pullets显示文摘 | Lewis P D Perry G C Morris T R | 1998 | Br Poult Sci1998，39，： | 1 |
| 10 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 11 | Modeling of substitutionin SAPO-5 and SAPO-34 molecular sieves 显示文摘 | Sastre G Lewis D W Catlolw C R | 1997 | Journal of Physical Chenistry1997，101，27： | 1 |
| 12 | The stretching frequencies of metal-oxygen double bonds显示文摘 | LEWIS J NYHOLM R S | 1959 | J Chem Soc1959，，： | 1 |
| 13 | Surface glycoprotein changes in ram spermatozoa during epididymal maturation显示文摘 | Voglmayr J K Fairbanks G Lewis R G | 1983 | Biol Reprod1983，29，： | 1 |
| 14 | Factor influencing the distribution of lindane and other hexachlorocyclohexane in the environment显示文摘 | Waller K Vallero D A Lewis R G | 1999 | Environmental Science and Technology1999，33，24： | 1 |
| 15 | Factors influencing the distribution of lindan and other hexachlorocyclohexanes in the environment 显示文摘 | Walker K Vallero D A Lewis R G | 1999 | Environ Sci Technol1999，33，： | 1 |
| 16 | Utility of MRI in the characterization of indeterminate small renal lesions previously seen on screening CT scans of potential renal donor patients显示文摘 | Fananapazir G Lamba R Lewis B | 2015 | AJR Am J Roentgenol2015，205，2： | 1 |
| 17 | Factors influencing the distribution of lindane and other hexachlorocyclohexanes in the environment 显示文摘 | Walker K VaUero D A Lewis R G | 1999 | Environmental Science and Technology1999，33，24： | 1 |
| 18 | Heart diseases affecting the liver and diseases affecting the heart显示文摘 | NASCHITZ J E SOLBODIN G LEWIS R J | 2000 | Am Heart J2000，140，： | 1 |
| 19 | Factors influencing the distributionof lindane and other hexachlorocyclohexanes in the environment显示文摘 | WALKER K VALLERO D A LEWIS R G | 1999 | Environmental Science&Technology1999，33，24： | 1 |
| 20 | Effect of constant and of changing photo period on plasma LH and FSH concentrations and age at first egg in layer strains of domestic pullets显示文摘 | LEWIS P D PERRY G C MORRIS T R | 1999 | Br Poult Sci1999，39，5： | 1 |
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