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| 1 | Effects of traditional Chinese medicine on treatment outcomes in severe COVID-19 patients:a single-centre study显示文摘As the search for effective treatments for COVID-19 continues,the high mortality rate among critically ill patients in Intensive Care Units(ICU)presents a profound challenge.This study explores the potential benefits of traditional Chinese medicine(TCM)as a supplementary treatment for severe COVID-19.A total of 110 critically ill COVID-19 patients at the Intensive Care Unit(ICU)of Vulcan Hill Hospital between Feb.,2020,and April,2020(Wuhan,China)participated in this observational study.All patients received standard supportive care protocols,with a subset of 81 also receiving TCM as an adjunct treatment.Clinical characteristics during the treatment period and the clinical outcome of each patient were closely monitored and analysed.Our findings indicated that the TCM group exhibited a significantly lower mortality rate compared with the non-TCM group(16 of 81 vs 24 of 29;0.3 vs 2.3 person/month).In the adjusted Cox proportional hazards models,TCM treatment was associated with improved survival odds(P<0.001).Furthermore,the analysis also revealed that TCM treatment could partially mitigate inflammatory responses,as evidenced by the reduced levels of proinflammatory cytokines,and contribute to the recovery of multiple organic functions,thereby potentially increasing the survival rate of critically ill COVID-19 patients. | XIAO Yongjiu LI Binbin LIU Chang HUANG Xiuyu MA Ling QIAN Zhirong ZHANG Xiaopeng ZHANG Qian LI Dunqing CAI Xiaoqing YAN Xiangyong LUO Shuping XIANG Dawei XIAO Kun | 2024 | Chinese Journal of Natural Medicines2024，22，1： | 0 |
| 2 | An exploration breakthrough in Paleozoic petroleum system of Huanghua Depression in Dagang Oilfield and its significance, North China显示文摘In recent years, several wells in the Qibei and Wumaying buried hills of Dagang Oilfield tapped oil in the Carboniferous–Permian and Ordovician strata. This major breakthrough reveals that the deep Paleozoic in the Bohai Bay is a new petroleum system. Through re-evaluating the Paleozoic source rock, reservoir-cap combinations and traps, it is found the oil and gas mainly come from Carboniferous–Permian source rock. The study shows that the Paleozoic strata are well preserved in the central-south Huanghua Depression and developed two kinds of reservoirs, Upper Paleozoic clastic rock and Lower Paleozoic carbonate rock, which form favorable source-reservoir assemblages with Carboniferous–Permian coal measure source rock. The Carboniferous–Permian coal-bearing source rock is rich in organic matters, which are mainly composed of type Ⅱ2 and Ⅲ kerogens, and minor Ⅱ1 kerogen in partial areas. Multi-stage tectonic movements resulted in two stages of hydrocarbon generation of the source rocks. The period from the deposition of Kongdian Formation to now is the second stage of hydrocarbon generation. The matching between large-scale oil and gas charging, favorable reservoir-cap combinations and stable structure determines the enrichment of oil and gas. According to the new comprehensive evaluation of Paleozoic petroleum system, the primary oil and gas resources of the Paleozoic in the Bohai Bay Basin are over 1×1012m3. The exploration breakthrough in Paleozoic petroleum system, especially Carboniferous–Permian petroleum system in Huanghua Depression is inspirational for oil and gas exploration in similar provinces of Bohai Bay Basin. | ZHAO Xianzheng PU Xiugang JIANG Wenya ZHOU Lihong JIN Fengming XIAO Dunqing FU Lixin LI Hongjun | 2019 | Petroleum Exploration and Development2019，46，4： | 0 |
| 3 | Magmatic hydrothermal fluid genesis of zeolite in the Paleogene Kongdian Formation of Zaoyuan oilfield,Bohai Bay Basin,China显示文摘Electronic probe,fluid inclusion homogenization temperature,Raman spectroscopy and laser ablation inductively coupled plasma mass spectrometry were utilized to identify the hydrothermal fluid-rock interactions in the second member of the Paleogene Kongdian Formation of Zaoyuan oilfield in Bohai Bay Basin(Kong 2 Member for short)of Well Z56 to find out the relationship between zeolite and hydrothermal fluid.The experimental results show that:(1)Pyrobitumen coexists with hydrothermal fluid characteristic minerals such as chlorite,barite,chalcopyrite,pyrite,natrolite and analcime in mudstone fractures.(2)The temperatures calculated from laser Raman spectrum of pyrobitumen,from the chlorite geothermometer and from measured homogenization temperature of natrolite inclusions are 324-354℃,124-166℃ and 89-196℃,respectively;although vary widely,all the temperatures are obviously higher than the normal geothermal temperature.(3)The positive Eu anomaly of chlorite and barite,and the similar distribution pattern in rare earth elements between natrolite and basalt indicate they are from magmatic hydrothermal fluid.Moreover,drilling data shows that the Kong 2 Member in Well Z56 has several sets of basalt interlayers,suggesting there was geologic base of magmatic hydrothermal fluid activity.The magmatic hydrothermal fluid-rock interaction may be one of the reasons for the abnormal enrichment of zeolite in Kong 2 Member of the Cangdong Sag. | HAN Guomeng WANG Li XIAO Dunqing LOU Da XU Muyue ZHAO Yonggang PEI Yanlu GUO Xiaowen TENG Jiancheng' HAN Yuanjia | 2021 | Petroleum Exploration and Development2021，48，5： | 0 |
| 4 | Mechanical property design method of cement sheath in a horizontal shale oil well under fracturing conditions显示文摘Based on the elastoplastic model of cement sheath considering the influence of three-dimensional principal stress and the stress field model of interface crack,a mechanical performance design method of cement sheath is established to meet the wellbore sealing requirements during fracturing.This method takes the failure types of the cement sheath,such as tensile failure,plastic yield,interface crack propagation along interface and zigzag propagation into account.Meanwhile,the elasticity modulus and Poisson's ratio quantitative design charts of cement sheath are constructed based on this method,and the safety and risk areas of wellbores are defined,which quantify the yield strength and tensile strength indexes of cement sheath.The results show that decreasing elasticity modulus,increasing yield strength and Poisson's ratio of cement sheath can avoid plastic deformation of cement sheath;increasing the tensile strength of cement sheath can prevent its tensile failure;increasing elasticity modulus and Poisson's ratio of cement sheath is good for shortening the length of the interface crack,but will increase the risk of interface cracks zigzagging into cement sheath.The model calculation and case verification has proved that the method in this paper can give accurate calculation results and is convenient for field application. | SU Donghua HUANG Sheng LI Zaoyuan LI Jin XIAO Dunqing WANG Ziyu LI Juan NI Shuai | 2022 | Petroleum Exploration and Development2022，49，4： | 0 |
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