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| 1 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 2 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Androgens and esophageal cancer: What do we know?显示文摘Significant disparities exist between genders for the development and progression of several gastrointestinal(GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvement of intrinsic gender-linked mechanisms is also possible for esophageal adenocarcinoma as its incidence is disproportionally high among men. However, the cause of the observed gender differences and the potential role of androgens in esophageal carcinogenesis remains unclear, even though the cancer-promoting role of androgen receptors(AR) shown in other cancers such as prostate and bladder suggests this aspect warrants exploration. Several studies have demonstrated expression of ARs in esophageal cancer. However, only one study has suggested a potential link between AR signaling and outcome- poorer prognosis. Two groups have analyzed data from cohorts with prostate cancer and one of these found a decreased incidence of esophageal squamous and adenocarcinoma after androgen deprivation therapy. However, very limited information is available about the effects of androgen and AR-initiated signaling on esophageal cancer cell growth in vitro and in vivo. Possible mechanisms for androgens/AR involvement in the regulation of esophageal cancer growth are considered, and the potential use of AR as a prognostic factor and clinical target is highlighted, although insufficient evidence is available to support clinical trials of novel therapies. As esophageal adenocarcinoma is a gender linked cancer with a large male predominance further studies are warranted to clarify the role of androgens and ARs in shaping intracellular signaling and genomic responses in esophageal cancer. | Olga A Sukocheva Bin Li Steven L Due Damian J Hussey David I Watson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 5 | Influence of aggregate structure and matrix infiltration on the dispersion behavior of carbon black agglomerates显示文摘 | Li Q Feke D L Manas Z I | 1995 | Rubb Chem Technol1995，68，5： | 1 |
| 6 | Recombinant BCG Tokyo (Ag85A) protects cynomolgus mon- keys (Macaca fascicularis) infected with H37Rv Mycobacterium tuberculosis 显示文摘 | Sugawara I Li Z Sun L Udagawa T Taniyama T | 2007 | Tuberculosis (Edinb)2007，87，6： | 1 |
| 7 | Potato response to crop sequence and nitrogen fertilization following sod breakup in a Gleyed Humo- Ferric Podzol显示文摘 | Li H L I~ Parent C T Karam A | 2009 | Can J Plant Sci2009，79，： | 1 |
| 8 | Ganoderiol F,a ganoderma triterpene,induces senescence in hepatoma HepG2 cells显示文摘 | CHANG U M LI C H LIN L I | 2006 | Life Sci2006，79，12： | 1 |
| 9 | Statistical modeling of complex backgrounds for foreground object detection 显示文摘 | Li L Huang W Gu I Y H | 2004 | IEEE Transactions on Image Processing2004，13，11： | 1 |
| 10 | Neuraminidase inhibitor sus- ceptibility testing of influenza type B viruses in China during 2010 and 2011 identifies viruses with reduced susceptibility to oseltamivir and zanamivir显示文摘 | Wang D Sleeman K Huang W Nguyen H T LevineM Cheng Y Li X Tan M Xing X Xu X Klimov A I Gubareva L V Shu Y | 2013 | Antiviral Research2013，97，3： | 1 |
| 11 | A software framework for matchmaking based on semantic web technology显示文摘 | LI L HORROCKS I | 2004 | International Journal of Electronic Commerce2004，8，4： | 1 |
| 12 | Electraless Ni-P deposition plus zinc phosphate coating on AZ91D magnesium alloy显示文摘 | Lian J S Li G I Niu L I | 2006 | Surface and Coatings Technology2006，200，20： | 1 |
| 13 | Large-area synthesis of high-quality and uniform graphene films on copper foils显示文摘 | LI Xue-song CAI Wei-wei AN Jin-ho KIM S NAH J YANG Dong-xing P1NER R VELAMAKANNI A JUNG I TUTUC E BANERJEE S K COLOMBO L RUOFF R S | 2009 | Science2009，324，5932： | 1 |
| 14 | NMR analysis of low molecular weight poly(lactic acid)s显示文摘 | Esoartero J L Rashkov I Li Manolova S M | 1996 | Macromolecules1996，29，10： | 1 |
| 15 | Systematic re- view of controlled clinical trials of gastric lavage in acute organophosphorus pesticide poisoning 显示文摘 | Li Y Tse M L Gawarammana I et aI | 2009 | Clin Toxicol (Phila)2009，47，3： | 1 |
| 16 | Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice显示文摘 | Li L Rasul I Liu J | | 0，，4： | 1 |
| 17 | Droplet bar- coding for single-cell transcriptomics applied to embryonic stem cells显示文摘 | Klein AM Mazutis L Akartuna I Tallapragada N Veres A Li V Peshkin L Weitz DA Kirschner MW | 2015 | Ceil2015，161，： | 1 |
| 18 | HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen显示文摘 | Li N Zhao D Kirschbaum M Zhang C Lin C L Todorov I | 2008 | Proc Natl Acad Sci USA2008，105，： | 1 |
| 19 | Hydriding combustion synthesis of Mg2NiH4显示文摘 | Saita I Li L Saito K | 2003 | Journal of Alloys and Compounds2003，，： | 1 |
| 20 | CD55 is overexpressed in the tumour environment 显示文摘 | Li L Spendlove I Morgan J | 2001 | Br J Cancer2001，84，1： | 1 |
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