| 1 | Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold显示文摘Critical oral-maxillofacial bone defects,damaged by trauma and tumors,not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct.Personalized biomaterials customized by 3D printing technology have the potential to match oralmaxillofacial bone repair and regeneration requirements.Laponite(LAP)nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity.Herein,porous nanosilicate-functionalized polycaprolactone(PCL/LAP)was fabricated by 3D printing technology,and its bioactivities in bone regeneration were investigated in vitro and in vivo.In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of bone marrow mesenchymal stem cells(BMSCs).PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion.Moreover,BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion.Then,PCL/LAP scaffolds were implanted into the calvarial defect model.Toxicological safety of PCL/LAP was confirmed,and significant enhancement of vascularized bone formation was observed.Taken together,3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction. | Xiongcheng Xu Long Xiao Yanmei Xu Jin Zhuo Xue Yang Li Li Nianqi Xiao Jing Tao Quan Zhong Yanfen Li Yuling Chen Zhibin Du Kai Luo | 2021 | Regenerative Biomaterials2021，8，6： | 3 |
| 2 | Characteristics Analysis of Condensation outside Horizontal Tube Bundles and Novel Condensation Enhancement Method显示文摘Condensation is a phase-change heat-transfer phenomenon crucial in many industries involving latent heat release and mass transfer.Shell-and-tube condensers are essential contributors to the condensation process,and their tube bundles serve as a substrate.Here,the thermal-hydraulic characteristics of condensation in a longitudinal-flow shell-and-tube condenser were investigated numerically.The shell-side longitudinal-flow condensation on the horizontal tube bundles was studied considering inlet flow rate,overheating temperature,and non-condensable gases.Related pressure drops and heat transfer coefficients were subdivided into several components to provide further insights.Two-phase interface behavior analyses were conducted to demonstrate the outcomes with respect to the non-condensable gas layer,vapor quality,and non-condensable gas type.Based on the thorough quantitative analyses outlined above,the thermal resistance of the condensation on the horizontal tube bundle was investigated.The thermal resistance outside the tube was found to dominate the condensation process.Finally,hexagon clamping baffles(HCBs)were introduced as a novel solution to impair condensate boundary layers and provide perturbations to intensify condensation heat transfer.The results revealed that the HCBs enhanced the total heat transfer coefficients by 8.1%–40.7%while reducing the critical overheating temperature and the threshold ratio between sensible and latent heat. | LI Nianqi TIAN Ke KE Hanbing ZENG Min WANG Qiuwang | 2022 | Journal of Thermal Science2022，31，3： | 0 |
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