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| 1 | In Vitro Probiotic Effect of Pseudostellaria heterophylla Fibrous Roots on Feed Bacillus subtilis and Preliminary Study on Its Solid Fermentation显示文摘Traditional Chinese medicine Pseudostellaria heterophylla fibrous roots have been widely studied and applied in non-antibiotic clinical breeding of livestock and poultry. In vitro probiotic effect of P. heterophylla fibrous roots extract on feed probiotics Bacillus subtilis BD-K010 was studied, and the feasibility of solid fermentation of P. heterophylla fibrous roots was preliminarily evaluated. For in vitro probiotic effect, the increased concentration of P. heterophylla fibrous roots extract dependently increased the total biomass of B. subtilis BD-K010;1.0% P. heterophylla fibrous roots extract received the best effect, and the final p H of 1.0% experimental group was closer to neutral. Meantime, B. subtilis BD-K010 with optimum concentration of P. heterophylla fibrous roots showed significantly higher in vitro antibacterial effect than the control group(P<0.01),and the antibacterial effects on Escherichia coli and Staphylococcus aureus were improved by 51.99% and 63.16%, but it was ineffective to Salmonella. For solid fermentation, the profile of substrate complex and appendage flocculent structure on substrate surface at the end of fermenta-tion in experimental groups added with B. subtilis BD-K010 and cellulase plus BD-K010 were more complex;the live bacteria number, polysaccharide content and saponin content at fermentation end-point in two experimental groups were extremely higher than those in the control group(P<0.01).P. heterophylla fibrous roots extract had good in vitro probiotic effect on B. subtilis BD-K010 and promoted its antibacterial effect, and it is feasible to use probiotics for solid fermentation of P. heterophylla fibrous roots and to improve effective components. It is of great significance to further de-velop and utilize P. heterophylla fibrous roots resources in modern animal husbandry. | Pan Huiqing Zhang Yanda Li Zhujin Zhao Qi | 2019 | Animal Husbandry and Feed Science2019，11，2： | 14 |
| 2 | Intelligent Flow Control Technique of ABR Service in ATM Networks Based on Fuzzy Neural Networks显示文摘InteligentFlowControlTechniqueofABRServiceinATMNetworksBasedonFuzzyNeuralNetworks①ZhangLiangjieLiYandaLiQinghuaWangPu(DeptofA... | Zhang Liangjie Li Yanda Li Qinghua Wang Pu (Dept of Automation, Tsinghua University, Beijing 100084) | 1997 | 通信学报1997，18，3： | 7 |
| 3 | Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method显示文摘Schizophrenia is a serious neuropsychiatric illness affecting about 1% of the world’s population. It is considered a complex inheritance disorder. A number of genes are involved in combination in the etiology of the disorder. Evidence implicates the altered dopaminergic trans- mission in schizophrenia. In the present study, in order to identify susceptibility genes for schizophrenia in dopaminergic metabolism, we analyzed 59 single nucleotide polymorphisms (SNPs) in 24 genes of the dopaminergic pathway among 82 unrelated patients with schizophre- nia and 108 matched normal controls. Considering that traditional single-locus association stud- ies ignore the multigenic nature of complex diseases and do not take into account possible in- teractions between susceptibility genes, we proposed a multi-locus analysis method, using the posterior probability of morbidity as a measure of absolute disease risk for a multi-locus genotype combination, and developed an algorithm based on perturbation and average to detect the sus- ceptibility multi-locus genotype combinations, as well as to repress noise and avoid false positive results at our best. A three-locus SNP genotype combination involved in the interactions of COMT and ALDH3B1 genes was detected to be significantly susceptible to schizophrenia. | SUN Xiangqing 1* , JIA Yanbin 2* , ZHANG Xuegong 1 , XU Qi 2 , SHEN Yan 2 & LI Yanda 1 1. Ministry of Education (MOE) Key Laboratory of Bioinformatics at Tsinghua University Department of Automation, Tsinghua University, Beijing 100084, China 2. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China | 2005 | Science China(Life Sciences)2005，48，3： | 2 |
| 4 | Complicated evolutionary patterns of microRNAs in vertebrates显示文摘MicroRNAs (miRNAs) are a class of ~22 nt long endogenous non-coding RNAs that play important regulatory roles in diverse organisms. Up to now, little is known about the evolutionary properties of these crucial regulators. Most miRNAs were thought to be phylogenetically conserved, but recently, a number of poorly-conserved miRNAs have been reported and miRNA innovation is shown to be an ongoing process. In this work, through the characterization of an miRNA super family, we studied the evolutionary patterns of miRNAs in vertebrates. Recently generated miRNAs seem to evolve rapidly during a certain period following their emergence. Multiple lineage-specific expansions were observed. Homolgous premiRNAs may produce mature products from the opposite stem arms following tandem duplications, which may have important contribution to miRNA innovation. Our observations of miRNAs' complicated evolutionary patterns support the notion that these key regulatory molecules may play very active roles in evolution. | WANG XiaoWo, ZHANG XueGong & LI YanDa MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST/Department of Automation, Tsinghua University, Beijing 100084, China | 2008 | Science China(Life Sciences)2008，51，6： | 2 |
| 5 | Validation of different personalized risk models of chemotherapy-induced nausea and vomiting:results of a randomized,double-blind,phase III trial of fosaprepitant for cancer patients treated with high-dose cisplatin显示文摘Background:Highly emetogenic chemotherapy induces emesis in cancer patients without prophylaxis.The purpose of this study was to evaluate the efficacy and safety of a fosaprepitant-based triple antiemetic regimen for the prevention of chemotherapy-induced nausea and vomiting(CINV)in patients with solid malignant tumors,determine risk factors and externally validate different personalized risk models for CINV.Methods:This phase III trial was designed to test the non-inferiority of fosaprepitant toward aprepitant in cancer patients who were to receive the first cycle of single-day cisplatin chemotherapy.The primary endpoint was complete response(CR)during the overall phase(OP)with a non-inferiority margin of 10.0%.Logistic regression modelswere used to assess the risk factors ofCRand no nausea.To validate the personalized risk models,the accuracy of the risk scoring systems was determined by measuring the specificity,sensitivity and area under the receiver operating characteristic(ROC)curve(AUC),while the predictive accuracy of the nomogram was measured using concordance index(C-index).Results:A total of 720 patients were randomly assigned.CR during the OP in the fosaprepitant group was not inferior to that in the aprepitant group(78.1%vs.77.7%,P=0.765)with a between-group difference of 0.4%(95%CI,-5.7%to 6.6%).Female sex,higher cisplatin dose(≥70 mg/m2),no history of drinking and larger body surface area(BSA)were significantly associated with nausea.The AUC for the acute and delayed CINV risk indexes was 0.68(95%CI:0.66-0.71)and 0.66(95%CI:0.61-0.70),respectively,and the C-index for nomogram CINV prediction was 0.59(95%CI,0.54-0.64).Using appropriate cutoff points,the three models could stratify patients with high-or low-risk CINV.No nausea and CR rate were significantly higher in the low-risk group than in the high-risk group(P<0.001).Conclusions:Fosaprepitant-based triple prophylaxis demonstrated non-inferior control for preventing CINV in patients treated with cisplatin-base chemotherapy.Female cancer patients without a history of alcohol consumption,with larger BSA and received high-dose cisplatin might be more vulnerable to CINV.Three personalized prediction models were well-validated and could be used to optimize antiemetic therapy for individual patients. | Yuanyuan Zhao Bing Zhao Gang Chen Yinlan Chen Zijun Liao Haiming Zhang Weineng Feng Yinyin Li Heng Weng Weidong Li Yuefen Zhou Biyong Ren Yanda Lu Jianhua Chen Zhenteng Liu Zhenzhong Su Wenliang Wang Li Zhang | 2023 | Cancer Communications2023，43，2： | 2 |
| 6 | Stable fuzzy adaptive control for a class of nonlinear systems显示文摘 | TANG Yuezhong ZHANG Naiyao LI Yanda | 1999 | Fuzzy Sets and Systems1999，104，2： | 1 |
| 7 | Subspaces of FMmlet transform显示文摘 | Hongxing Zou Qionghai Dai Ke Zhao Guiming Chen Yanda Li | 2002 | Science in China Series : Information Sciences2002，，2： | 1 |
| 8 | Prediction of protein subcellular locations using fuzzy κ-NN method显示文摘 | Ying Huang Yanda Li | 2004 | Bioinformatics2004，20，： | 1 |
| 9 | Approximation capability of fuzzy systems using translation and dilations of one fixed function as membership functions显示文摘 | LI Yanda ZHANG Xuefeng | 1997 | IEEE Transaction on Fuzzy Systems1997，5，3： | 1 |
| 10 | Machine learning and intelligence science: IScIDE (C)显示文摘 | Lei XU Yanda LI | 2012 | Frontiers of Electrical and Electronic Engineering in China2012，7，1： | 1 |
| 11 | Stable fuzzy adaptive control for a class of nonlinear systems显示文摘 | Yuezhong Tang Naiyou Zhang Yanda Li | 1999 | Fuzzy sets and systems (S0165-0114)1999，104，2： | 1 |
| 12 | Recent advances in RNA structurome显示文摘RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of functionality across a wide range of species. In this review, we summarize key strategies for probing the RNA structurome and discuss the pros and cons of representative technologies. In particular, these new technologies have been applied to dissect the structural landscape of the SARS-CoV-2 RNA genome. We also summarize the functionalities of RNA structures discovered in different regulatory layers-including RNA processing, transport, localization, and mRNA translation-across viruses, bacteria, animals, and plants. We review many versatile RNA structural elements in the context of different physiological and pathological processes(e.g., cell differentiation, stress response, and viral replication). Finally, we discuss future prospects for RNA structural studies to map the RNA structurome at higher resolution and at the single-molecule and single-cell level, and to decipher novel modes of RNA structures and functions for innovative applications. | Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 13 | An approach of adaptive fuzzy control and its application to power systems显示文摘 | TANG YUE ZHONG ZHANG NAIYAO LI YANDA | 1999 | 'Fuzzy Logic and Soft Computing'by Kluwer Academic Publishers1999，，： | 1 |
| 14 | Stable fuzzy adaptive control for a class of nonlinear systems显示文摘 | TANG Yuezhong ZHANG Naiyao LI Yanda | 1999 | Fuzzy Sets and Systems1999，104，2： | 1 |
| 15 | Stable fuzzy adaptive control for a class of nonlinear systems显示文摘 | Tong Yuezhang Zhang Naiyao Li Yanda | 1999 | Fuzzy Sets and System1999，104，2： | 1 |
| 16 | Stable fuzzy adaptive control for a class of nonlinear systems 显示文摘 | Yuezhong Tang Naiyou Zhang Yanda Li | 1999 | Fuzzy sets and systems (S0165-0114)1999，104，2： | 1 |
| 17 | Identifying splicing sites in eukaryotic RNA: Support vector machine approach显示文摘 | SUN Yingfei FAN Xiaodan LI Yanda | 2003 | Computersuin Biology and Medione2003，33，： | 1 |
| 18 | CORS: A Cooperative Overlay Routing Service to Enhance Interactive Multimedia Communications显示文摘 | Li Tang Zhen Chen Hao Yin Jun Li and Yanda Li | 2010 | Journal of Visual Communication and Image Representation2010，21，02： | 1 |
| 19 | SVD row or column symmetric matrix显示文摘A new architecture for row or column symmetric matrix called extended matrix is defined, and a precise correspondence of the singular values and singular vectors between the extended matrix and its original (namely, the mother matrix) is derived. As an illustration of potential, we show that, for a class of extended matrices, the singular value decomposition using the mother matrix rather than the extended matrix per se can save the CPU time and memory without loss of numerical precision. | ZOU Hongxing WANG Dianjun DAI Qionghai LI Yanda | 2000 | Chinese Science Bulletin2000，45，22： | 1 |
| 20 | Directed variation in evolution strategies显示文摘 | Zhou Qing Li Yanda | 2003 | IEEE Transactions on Evolutionary Computation2003，7，4： | 1 |
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