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| 1 | Selective matrix metalloproteinase inhibitors for cancer显示文摘 | Lia N G Shib Z H Tang Y P Duan J A | 2009 | Curr Med Chem2009，16，29： | 1 |
| 2 | Effect of La on the wettability of Al2O3 by molten aluminum显示文摘 | Shao N Dai J W Lia G Y | 2004 | Materials Letters2004，58，： | 1 |
| 3 | Etiology and treatment of pediatric sixth nerve palsy显示文摘 | Merino P Gómez de Lia(n)o P Villalobo JM | | 0，，： | 1 |
| 4 | New methodology to evaluate the rolling contact fatigue performance of bearing steels with surface dents:application to 32CrMoV13 and M50 steels显示文摘 | Nélias D Jacq C Lormand G | 2005 | J Tribol2005，127，61： | 1 |
| 5 | D esig n,Analysis,Prototyping, and Experimental Evaluation of anEficient Double Coil Magnetorhieological Valve 显示文摘 | H U G u o lia n g LONGM ing HUANGM in etal | | Advancesin Mechanical Engineering0，，： | 1 |
| 6 | A grey-based decision-making approach to the supplier selection problem显示文摘 | LIA G D DAISUKE Y MASATAKE N | 2007 | Math Comput Mod2007，46，3： | 1 |
| 7 | AFM indentation study of breast cancer cells显示文摘 | LIA Q S LEE G Y ONG C N | 2008 | Biochem Biophys Res Commun2008，374，4： | 1 |
| 8 | Prevalence of celiac disease in an urban area of Brazil with predominantly European ancestry显示文摘AIM: To determine the prevalence of celiac disease in a group of volunteer blood donors at a blood bank in the city of Curitiba, Brazil through detection of the serum marker immunoglobulin A (IgA) antitransglutaminase an-tibody.METHODS: Blood samples collected from 2086 healthy subjects at the Paraná State Center for Hematology and Hemotherapy in Curitiba were submitted to ELISA testing for the IgA antitransglutaminase antibody. Positive samples received IgA antiendomysium antibody test through indirect immunofluorescence using human umbilical cord as substrate. Subsequently, patients who were positive on both tests underwent small bowel (distal duodenum) biopsy.RESULTS: Six subjects, four males and two females, tested positive for the two serum markers. Five of the six were submitted to intestinal biopsy (one declined the procedure). Biopsy results revealed changes in the distal duodenum mucosa (three classified as Marsh Ⅲb lesions and two as Marsh Ⅱ lesions). Most donors diagnosed having celiac disease presented multiple symptoms (gastrointestinal tract complaints). One donor reported having a family history of celiac disease (in a niece).CONCLUSION: Among apparently healthy blood donors,the prevalence of biopsy-confirmed celiac disease was approximately 1:417, similar to that seen in European countries. | Maria Angélica G Pereira Carmen L Ortiz-Agostinho Iêda Nishitokukado Maria N Sato Adérson OMC Damio Marília L Alencar Clarice P Abrantes-Lemos Eduardo LR Canado Thales de Brito Sérgio O Ioshii Sandra BM Valarini Aytan M Sipahi | 2006 | World Journal of Gastroenterology2006，12，40： | 1 |
| 9 | Comparison of separation performances of novel β -cyclodextrin-based chiral stationary phases in high-performance liquid chromatographic enantioseparation显示文摘 | Gábor Varga Gábor Fodor István Ilisz Julianna Szemán Júlia Visy Lajos Szente Antal Péter | 2012 | Journal of Pharmaceutical and Biomedical Analysis2012，，： | 1 |
| 10 | Development of a three-dimensional semi-analytical elastic-plastic contact code显示文摘 | Jacq C Nélias D Lormand G and Girodin D | | 0，，04： | 1 |
| 11 | Rectorite/thermoplastic Polyurethane Nanocomposites: Preparation, Characterization,and Properties 显示文摘 | M A X Y LU H J LIA N G G Z | 2004 | Journal of Applied Polymer Science2004，93，2： | 1 |
| 12 | Selective matrixmetalloproteinase inhibitors for cancer 显示文摘 | LIA N G SHIB Z H TANG Y P | 2009 | Curr Med Chem2009，16，29： | 1 |
| 13 | Mollusk shell formation: Mapping the distribution of organic matrix components under- lying a single aragonitic tablet in nacre 显示文摘 | FABIO N BAT A G LIA A | 2006 | Journal of Stru- crural Biology2006，153，2： | 1 |
| 14 | Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors显示文摘Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support methods.Digital drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted agents.DDA has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical trial.The aim of this study was to evaluate the utility of DDA in pediatric oncology.Methods Between 2017 and 2020,103 high-risk pediatric cancer patients(<21 years)were involved in our precision oncology program,and samples from 100 patients were eligible for further analysis.Tissue or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision support.Finally,a molecular tumor board(MTB)evaluated the results to provide therapy recommendations.Results Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing results.DDA identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug resistance.Actionability reached 88%(29/33)by 2020 due to the continuous updates of the evidence database.MTB approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed therapies.Filtering of WES results for targeted panels missed important mutations affecting therapy selection.Conclusions DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine care of high-risk pediatric cancers.Knowledgebase updates enable automatic interpretation of a continuously expanding gene set,a“virtual”panel,filtered out from genome-wide analysis to always maximize the performance of precision treatment planning. | Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták | 2023 | World Journal of Pediatrics2023，19，10： | 0 |
| 15 | Twelve-month efficacy and safety of the conversion to everolimus in maintenance heart transplant recipients显示文摘AIM: To determine the clinical reasons for conversion to everolimus(EVL) and long-term outcomes in heart transplant(HT) recipients.METHODS: A retrospective 12-mo study has been carried out in 14 Spanish centres to assess the efficacy and safety of conversion to EVL in maintenance HT recipients.RESULTS: Two hundred and twenty-two patients were included(mean age: 53 ± 10.5 years; mean time from HT: 8.1 ± 4.5 years). The most common reasons for conversion were nephrotoxicity(30%), chronic allograft vasculopathy(20%) and neoplasms(17%). The doses and mean levels of EVL at baseline(conversion to EVL) and after one year were 1.3 ± 0.3 and 1.2 ± 0.6 mg/d and 6.4 ± 3.4 and 5.6 ± 2.5 ng/mL, respectively. The percentage of patients receiving calcineurin inhibitors(CNIs) at baseline and on the final visit was 95% and 65%, respectively. The doses and mean levels of CNIs decreased between baseline and month 12 from 142.2 ± 51.6 to 98.0 ± 39.4 mg/d(P < 0.001) and from 126.1 ± 50.9 to 89.2 ± 47.7 ng/mL(P < 0.001), respectively, for cyclosporine, and from 2.9 ± 1.8 to 2.6 ± 1.9 mg/d and from 8.3 ± 4.0 to 6.5 ± 2.7 ng/mL(P = 0.011) for tacrolimus. In the subgroup of patients converted because of nephrotoxicity, creatinine clearance increased from 34.9 ± 10.1 to 40.4 ± 14.4 mL/min(P < 0.001). There were 37 episodes of acute rejection in 24 patients(11%). The most frequent adverse events were oedemas(12%), infections(9%) and gastrointestinal problems(6%). EVL was suspended in 44 patients(20%). Since the database was closed at the end of the study, no further followup data is available.CONCLUSION: Conversion to EVL in maintenance HT recipients allowed minimisation or suspension of the CNIs, with improved kidney function in the patients with nephrotoxicity, after 12 mo. | Nicolás Manito Juan F Delgado María G Crespo-Leiro José María Arizón Javier Segovia Francisco González-Vílchez Sònia Mirabet Ernesto Lage Domingo Pascual-Figal Beatriz Díaz Jesús Palomo Gregorio Rábago Marisa Sanz Teresa Blasco Eulàlia Roig | 2015 | World Journal of Transplantation2015，5，4： | 0 |
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