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| 1 | Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial显示文摘Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence outcomes.We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in AIS.Methods ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with AIS.Results Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with AIS.Although China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China participants.There was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China participants.Conclusion Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions. | Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers Craig S Anderson | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 2 | NGF promotes hemo dynamic recovery in a rabbit hindlimb ischemic model through trkA and VEGFR2-dcpendent pathways显示文摘 | Karatzas A Katsanos K Lilis I | 2013 | J Cardiovasc Pharmacol2013，62，3： | 1 |
| 3 | Distributed Rule-regulated SpectrumSharing 显示文摘 | I Cao Lili Zheng Haitao | 2008 | IEEE Journal on Selected Areas in Communications2008，26，1： | 1 |
| 4 | Volatiles and Harvest Maturity of Peaches and Nectarines显示文摘 | LILY L I M ROMANI R J | 1963 | J Food Sci1963，29，： | 1 |
| 5 | Smoking influences outcome in patients who had thrombolysed ischaemic stroke:the ENCHANTED study显示文摘Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke(AIS),we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study(ENCHANTED).Methods Post-hoc analyses of ENCHANTED,an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed AIS.Multivariable logistic regression models with inverse probability of treatment weighting(IPTW)propensity scores were used to determine associations of self-reported smoking status and clinical outcomes,according to 90-day modified Rankin Scale(mRS)scores and symptomatic intracerebral haemorrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current smokers who were younger and predominantly male,with more comorbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes mellitus,and greater baseline neurological impairment,compared with non-smokers.In univariate analysis,current smokers had a higher likelihood of a favourable shift in mRS scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted model with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A similar trend was also apparent for dichotomised poor outcome(mRS scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard criteria.Conclusion Smoking predicts poor functional recovery in patients who had thrombolysed AIS.Trial registration number NCT01422616. | Lingli Sun Lili Song Jie Yang Richard I Lindley Thompson Robinson Pablo M Lavados Candice Delcourt Hisatomi Arima Bruce Ovbiagele John Chalmers Craig S Anderson Xia Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
| 6 | NGF promotes hemodynamic recovery in a rabbit hindlimb ischemic model through trkA- and VEGFR2-dependent pathways 显示文摘 | Karatzas A Katsanos K Lilis I | 2013 | J Cardiovasc Pharmacol2013，62，3： | 1 |
| 7 | NGF promotes hemodynam- ic recovery in a rabbit hindlimb ischemic model through trkA-and VEGFR2-dependent pathways显示文摘 | Karatzas A Katsanos K Lilis I | 2013 | J Cardiovasc Pharmacol2013，62，3： | 1 |
| 8 | The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses显示文摘 | Efrem S Lim Lily I Wu Harmit S Malik Michael Emerman | 2012 | Retrovirology2012，9，1： | 1 |
| 9 | Comprehensive evaluation of nuclear factor-kP expressionpatterns in non-small cell lung cancer 显示文摘 | GIOPANOU I LILIS I PAPALEONIDOPOULOS V | 2015 | PLoS One2015，10，7： | 1 |
| 10 | Overexpression of apple spermidine synthase 1 (MdSPDS1) leads to significant salt tolerance in tomato plants显示文摘 | NEILY M H BALDET P ARFAOUI I SAITO T QIU Lili ASAMIZU E MATSUKURA C MORIGUCHI T EZURA H | 2011 | Plant Bio- technology2011，28，1： | 1 |
| 11 | Effect of dexmedetomidine onlung ischemia?reperfusion injury显示文摘 | Jiang Lili Li L i Shen Jinmei | 2014 | Mol Med Reports2014，9，2： | 1 |
| 12 | 建筑中的城市显示文摘'一切超越凡人者均为无形之物,如果能够拥有有形之风,将是何等不同!——赫尔曼麦尔维尔《白鲸记》哈姆雷特:你看到那边的云了吗,形状像一头骆驼?波洛涅斯:我发誓,它确实像一头骆驼。哈姆雷特:我认为,它像一只黄鼠狼。波洛涅斯:那背像黄鼠狼。哈姆雷特:或者说像一条鲸鱼吧。波洛涅斯:很像一条鲸鱼。——威廉莎士比亚《哈姆雷特》第二幕。 | 蓝天组(Coop Himmelb(I)au) Lili Cristiano Bianchi Duccio Malagamba | 2013 | 缤纷2013，0，4： | 0 |
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