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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 3 | DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum显示文摘 | Carneiro F S Giachini F R Lima V V | 2008 | Can J Physiol Pharmacol2008，86，6： | 1 |
| 4 | Anionic flotation of railings of manganese ore 显示文摘 | Lima R M F Vasconcelos J A da Silva G R | 2008 | Rem-revista Escolade Minas2008，61，3： | 1 |
| 5 | ln vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions显示文摘 | Lima S R M Junior V F V Christo H B | 2003 | Phytotherapy Research2003，17，9： | 1 |
| 6 | β-1,3-glucanase activity of two saprophytic yeasts and possible mode of action as biocontrol agents against postharvest diseases显示文摘 | CASTORIA R DE CURTIS F LIMA G | | 0，，： | 1 |
| 7 | Prognostic factors and out- come for nasopharyngeal carcinoma 显示文摘 | Farias T P Dias F L Lima R A | 2003 | Arch Otolalyngol Head Neek Surg2003，129，7： | 1 |
| 8 | Effect of combined ensiling of sorghum and soybean with or without molasses and lactobacilli on silage quality and in vitro rumen fermentation显示文摘 | Lima R Lourenco M Diaz R F | 2010 | Animal Feed Science and Technology2010，155，2： | 1 |
| 9 | Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer显示文摘 | LIMA R A FREITAS E Q DIAS F L | 2006 | Head Neck2006，28，： | 1 |
| 10 | Structural assessment of minor axis steel joints using photoelasticity and finite elements 显示文摘 | Lima L R O Freire J L F Vellasco P C G S | 2009 | Journal of Constructional Steel Research2009，65，2： | 1 |
| 11 | Integrated control of apple postharvest pathogens and survival of biocontrol yeasts in semi-commercialconditions显示文摘 | Lima Q de Curtis F Castoria R | 2003 | European Journal of Plant Pathology2003，109，： | 1 |
| 12 | Effect of source of supplemental selenium on uterine health and embryo quality in high-producing dairy cows显示文摘 | Cerri R L A Rutigliano H M Lima F S | 2009 | Theriogenology2009，71，7： | 1 |
| 13 | Hypertension in postmenopausal women显示文摘 | Lima R Wofford M Jane F | 2012 | Curr Hypertens Rep2012，14，3： | 1 |
| 14 | Glioblastoma: therapeutic challenges, what lies ahead 显示文摘 | LIMA F R KAHN S A SOLETYI R C | 2012 | BBA2012，1826，12： | 1 |
| 15 | Integrated control of blue mould using new fungicides and biocontrol yeasts lowers levels of fungicides residues and patulin contamination in apples显示文摘 | LIMA G CASTORIA R CURTIS F D | | 0，，02： | 1 |
| 16 | Polymer coated vermiculite-iron composies: Novel floatable magnetic adsorbents for water spilled contaminants显示文摘 | L C R Machado F W J Lima R Paniago | 2006 | Applied Clay Science2006，31，： | 1 |
| 17 | β-1,3-glucanase activity of two saprophytic yeasts and possible mode of action as biocontrol agents against postharvest diseases显示文摘 | CASTORIA R DE CURTIS F LIMA G | | 0，，03： | 1 |
| 18 | Relevance of skip metastases for squamous cell carcinoma of the oral tongue and the floor of the mouth显示文摘 | DIAS F L LIMA R A KLIGERMAN J | 2006 | Otolaryngol Head Neck Surg2006，134，3： | 1 |
| 19 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 20 | 显示文摘 | Abreu F R Lima D G Hamu E H | 2003 | JAOCS2003，80，6： | 1 |
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