3篇
您的检索式：作者名="LIN Kechun"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interaction of HIV-1 fusion peptide and its mutant with lipid membrane显示文摘HIVWT and HIVV2E represent the 23 amino acids fusion peptide of HIV-1 gp41 N terminus and its position 2 mutant (Val→Glu). We have studied the structure-function relationship of HIVWT and HIVV2E when they interact with acidic and neutral lipid membranes. The results show that HIVWT and HIVV2E have the same conformational characteristics and tendencies of conformational transition but definitely different functions: HIVWT destabilizes membrane and induces fusion by adopting predominant α-helix conformation when interacting with acidic POPG membrane, its phenylalanine residues can penetrate into the hydrophobic core of POPG bilayer; HIVV2E also adopts predominant α-helix when interacting with POPG membrane, but it cannot destabilize POPG membrane and induce fusion, the phenylalanine residues of it are located near the surface of POPG bilayer. HIVWT and HIVV2E both adopt predominant β-sheet conformation to interact with neutral POPC membrane, and cannot destabilize POPC membrane and induce fusion, | QIU Yang SHA Yinlin HUANG Lixin LIN Kechun NIE Songqing | 2000 | Chinese Science Bulletin2000，45，9： | 1 |
| 2 | Abnormal behavior of fluorescence quenching of gramicidin A inphase transition of lipid vesicles by hypocrellin B——Does anelectron transfer inverted region exist?显示文摘The fluorescence of gramicidin A(GA) in lipid bilayer may be quenched by Hypocre-Ilin B. When the phospholipids undergo a phase transition from gel to liquid crystalline phase, the reaction rate decreases unusually. This phenomenon has been analyzed by Marcus’ pho-toinduced electron theory, and an electron transfer inverted region hypothesis is proposed, | Jiachang Yue Yeping Li Yaxian Su Kechun Lin | 1999 | Chinese Science Bulletin1999，44，21： | 0 |
| 3 | Effect of Ab_(1-40) on membrane permeability and intracellular free Ca^(2+) of nerve cells显示文摘The effects of soluble and fibrillar Ab1-40 on membrane permeability and intracellular free Ca2+ of nerve cells were investigated by the laser confocal microscopy. Results indicate that: i) Effects of soluble and fibrillar Ab1-40 on cell membrane permeability are both concentration-de- pendent. Soluble Ab1-40 increases membrane permeability only at concentration of 3 mmol/L, while the toxic effect of fibrillar Ab1-40 is much stronger, its evident effect begins from 1 mmol/L. When its concentration rose to 3 mmol/L, not only the membrane permeability increased, but also the nuclear membrane broke seriously. ii) Both soluble and fibrillar Ab1-40 at high concentrations increased the intracellular free Ca2+, and the increased amplitudes are concentration-dependent. However, the fibrillar one induces the increase of intracellular Ca2+ much quicker and synchronously. These results indicate that some correlation exists between the neurotoxicity of high concentration soluble and fibrillar Ab1-40 and the change of physico-chemical properties and intracellular Ca ion imbalance. | MA Xiaocui, SHA Yinlin, LIN Kechun & NIE Songqing Department of Biophysics, Peking University Health Science Center, Beijing 100083, China | 2003 | Chinese Science Bulletin2003，48，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员