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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Comparison of cer- ebral blood volume and permeability in preoperative grading of intraeranial glioma using CT perfusion imaging 显示文摘 | DING B LING H W CHEN K M | 2006 | Neurora- diology2006，48，10： | 1 |
| 3 | Passive trader of protective immunity against ichthyophthiriais from vaccinated mother to fry in tilapias,Oreochromis aureus显示文摘 | SIN Y M LING K H LAM T J | 1994 | Aquaculture1994，120，： | 1 |
| 4 | Effects of temperature and chemical formulation on the acute toxicity of pentachlorophenol to Simocephalus vetulus (Schoedler, 1858) (Crustacea:Cladocera)显示文摘 | Willis K J N Ling M A Chapman | 1995 | N Z J Mar Freshw Res1995，29，2： | 1 |
| 5 | Overexpression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16 (INK4a)/RB pathway显示文摘 | Lee T K Man K Ling M T | 2003 | Carcinogenesis2003，24，11： | 1 |
| 6 | Systematic screening and char- acterization of the major bioactive components of Poria cocos and their metabolites in rats by LC-ESI-MS(n) 显示文摘 | Ling Y Chen M Wang K | 2012 | Biomed Chroma- togr2012，26，9： | 1 |
| 7 | Measuring the Symptom Experience of Chinese Cancer Patients: A Valida- tion of the Chinese Version of the Memorial Symptom Assess- ment Scale显示文摘 | Cheng K K Wong E M Ling W M | 2009 | J Pain Symptom Manage2009，37，1： | 1 |
| 8 | Nature of the Acceptor Responsible for p-Type Conduction in Liquid Encapsulated Czochralski-Grown Undoped Gallium Antimonide显示文摘 | Ling C C Lui M K Ma S K | 2004 | Appl Phys Lett2004，85，： | 1 |
| 9 | Effect of dietary HUFA on reproductive performance, tissue fatty acid profile and desaturase and elongase mRNAs in female swordtail Xiphophorus helleri 显示文摘 | Ling S Kuah M K TengkuMuhammad T S | 2006 | Aquaculture2006，，： | 1 |
| 10 | Measuring theSymptom Experience of Chinese Cancer Patients:A Valida-tion of the Chinese Version of the Memorial Symptom As-sessment Scale显示文摘 | Cheng K K Wong E M Ling W M | 2009 | J Pain Symptom Manage2009，37，1： | 1 |
| 11 | The Symptom Cluster of Fatigue,Pain,Anxiety,and Depression and the Effect on the Quality of Life of Women Receiving Treatment for Breast Cancer:a Multicenter Study显示文摘 | So W K Marsh G Ling W M | 2009 | Oncol Nurs Forum2009，36，4： | 1 |
| 12 | Health service de- livery in China:A literature review 显示文摘 | Eggleston K Ling L Qingyue M | 2008 | Health Economic2008，17，： | 1 |
| 13 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 14 | Electron Irradiated Liquid Encapsulated Czochralski Grown Undoped Gallium Antimonide Studied by Positron Lifetime Spectroscopy and Photoluminescence显示文摘 | Ma S K Lui M K Ling C C | 2004 | J Phys:Condens Matter2004，16，： | 1 |
| 15 | Chaos and NDFT-Based Concealing of Fingerprintbiometric Data into Audio Signals for Trustworthy Person Authentication显示文摘 | KHAN M K XIE Ling ZHANG Jiashu | 2010 | Digital Signal Processing2010，20，1： | 1 |
| 16 | Changes in microflora and biochemical composition dur- ing the baceman stage of traditional Indonesian kecap ( soy sauce) production显示文摘 | Roling Ling W F M Timotius K H Budhi Prasetyo A | 1994 | Journal of Fermentation and Bioen- gineering1994，77，1： | 1 |
| 17 | Characteristics of Mg-based composites synthesized using a novel mechanical disintegration and deposition technique 显示文摘 | Oo M K K Ling P S Gupta M | 2000 | Metall Mater Trans A2000，31，： | 1 |
| 18 | Association of feather color with constitutively ac-tive Melanocortin I receptors in chicken 显示文摘 | LING M K LAGERSTROM M C FREDRIKSSON R | 2003 | Eur J Bioehem2003，270，： | 1 |
| 19 | Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target 显示文摘 | Kwok W K Ling M T Lee T W | 2005 | Cancer Res2005，65，12： | 1 |
| 20 | Physical factors influencing microbial interactions and bio- chemical changes during the baceman stage of Indonesian kecap (soy sauce) production显示文摘 | Roling Ling W F M Timotius K H Stouthamer A H | 1994 | Journal of Fermentation and Bioengineering1994，77，3： | 1 |
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