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| 1 | Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates显示文摘AIM: To investigate the prevalence of vacuolating cytotoxin (vacA), cytotoxin associated gene A (cagA) and blood adhesion binding antigen (babA2) genotypes of Helicobacter pylori (H pylori) isolates from Cuban dyspeptic patients. METHODS: DNA was extracted from H pylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specifi c primers for vacA (s1, s2, m1, m2), cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS: vacA alleles s1 , s2 , m1 and m2 were detected in 96 (73.8%), 34 (26.2%), 75 (57.7%) and 52 isolates (40%), respectively, while the cagA gene was detected in 95 isolates (73.2%). One hundred and seven isolates (82.3%) were babA2-positive. A signif icant correlation was observed between vacAs1m1 and cagA and between vacAs1m1 and babA2 genotypes (P < 0.001 and P < 0.05, respectively) and between babA2 genotype and cagA status (P < 0.05); but, no correlation was observed between vacAs1 and babA2 genotypes. Eighty fi ve (65.4%) and 73 (56.2%) strains were type 1 (vacAs1-cagA-positive) and 'triple- positive' (vacAs1-cagA-babA2-positive), respectively, and their presence was significantly associated with duodenal ulcer (P < 0.01 and P < 0.001, respectively). CONCLUSION: The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were signifi cantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied. | Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín Hernández Ludisleydis Bermúdez Boris L Rodríguez | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 2 | Occurrence Of Fumonisins B1 And B2 In Portuguese Maize And Maize-Based Foods Intended For Human Consumption显示文摘 | Silva L Lino C M Pena A | 2007 | Food Addit Contam2007，24，4： | 1 |
| 3 | Adrenal ganglioneuromas:incidentalomas with misleading clinical and imaging features显示文摘 | Linos D Tsirlis T Kapralou A | | 0，，： | 1 |
| 4 | Determination of organochlorine pesticide residues in honey from the central zone of Portugal and the Valencian community of Spain 显示文摘 | Blasco C Lino CM Pico Y Pena A Font G Silveira M I N | 2004 | Journal of Chromatography A2004，1049，12： | 1 |
| 5 | Percutaneous pulmonary polyure-thane valved stent implantation 显示文摘 | Metzner A lino K Steinseifer U Uebing A de BuhrW Cremer J | 2010 | J Thorac Cardio-vasc Surg2010，139，： | 1 |
| 6 | Analysis of Fructans from Higher Plants by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry显示文摘 | Stahl B Linos A Karas M | 1997 | Anal Biochem1997，246，2： | 1 |
| 7 | Serological of chronic hepatitis B infection revisited 显示文摘 | Maruyama T Mclanchlao A Lino S | 1993 | Clin Invest1993，91，9： | 1 |
| 8 | Indoor and outdoor personal exposure to benzene in Athens,Greece显示文摘 | Chatzis C Alexopoulos EC Linos A | 2005 | Sci Total Environ2005，349，13： | 1 |
| 9 | Tribological behaviour of epoxy based composites for rapid tooling显示文摘 | Vasconcelos P V Lino F J Baptists A M | 2006 | Wear2006，260，12： | 1 |
| 10 | Incidence and natural history of primary systemic amyloidosis in Olmstead County, Minesota, 1950 through 1989 显示文摘 | Kyle RA Linos A Beard CM | 1992 | Blood1992，79，7： | 1 |
| 11 | Neural network nonlinear modeling of a common rail injection system for a CNG engine显示文摘 | Maione B Lino P Rizzo A | 2004 | WSEAS Transaction on Systems2004，3，5： | 1 |
| 12 | Adrenaloma: A Call for More Aggressive Management显示文摘 | Linos D A Stylopoulos N Raptis S A | 1996 | World J Surg1996，20，： | 1 |
| 13 | Time-of-use tariff design under uncertainty in price-elasticities of electricity demand: A stochastic optimization approach 显示文摘 | DE Sa FERREIRA R BARROSO L A LINO P R | 2013 | IEEE Transactions on Smart Grid2013，4，4： | 1 |
| 14 | CD25 -T cells generate CD25 + Foxp3 + regulatory T cells by peripheral expansion 显示文摘 | Curotto de Lafaille M A Lino A C Kutchukhidze N | 2004 | J Immunol2004，173，12： | 1 |
| 15 | Adrenal ganglioneuromas:incidentalomas with misleading clinical and imaging features显示文摘 | Linos D Tsirlis T Kapralou A | | 0，，01： | 1 |
| 16 | Family history as a risk factor for rheumatoid arthritis: a case -control study显示文摘 | KOUMANTAKI Y GIZIAKI E LINOS A | 2002 | J Rheumatol2002，24，： | 1 |
| 17 | Neoplastic progression occurs through mutator pathways in hyperplastic polyposis of colorectum 显示文摘 | Jass JR Lino H Ruszkiewiez A | 2000 | Gut2000，47，1： | 1 |
| 18 | Respiratory Disease Related Mortality and Morbidity on an Island of Greece Exposed to Perlite and Bentonite Mining Dust显示文摘 | Sampatakakis S Linos A Papadimitriou E | 2013 | Int J Environ Res Public Health2013，10，10： | 1 |
| 19 | Positive marginsin laparoscopic partial nephrectomy in 855 cases: a muhi-institu- tional survey from the United Statesand Europe 显示文摘 | BREDA A STEPANIAN SV LINO J | 2007 | J Llrol2007，178，： | 1 |
| 20 | Microstructural refinement by Cu addition and its effect onstrengthening and toughening of sour service line pipe steels显示文摘 | Takahashi A Lino M | 1996 | ISIJ Inter1996，32，2： | 1 |
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