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| 1 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 2 | A Statistical Study on Seismo-Ionospheric Anomalies of the Total Electron Content for the Period of 56 M≥6.0 Earthquakes Occurring in China During 1998—2012显示文摘This paper reports statistical results of Seismo-Ionospheric Anomalies(SIAs) of the Total Electron Content(TEC) in the Global Ionosphere Map(GIM) associated with 56 M≥6.0 earthquakes in China during 1998—2012.To detect SIA,a quartile-based(i.e.median-based) process is performed.TEC anomalies for the period of earthquakes without being led by magnetic storms about 10 days are further isolated and examined to confirm the SIP existence.Results show that SIA is the TEC significantly decrease in the afternoon period 2—9 days before the earthquakes in China,which is in a good agreement with the SIA appearing before the 12 May 2008 M 8.0 Wenchuan earthquake. | Liu J Y Chen C H Tsai H F Le H | 2013 | 空间科学学报2013，33，3： | 7 |
| 3 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 4 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 5 | Biaxial stress-strain relations for concrete显示文摘 | Liu T C Y Nilson A H Slate F O | 1972 | Journal of Structural Division1972，98，5： | 2 |
| 6 | Additional conjugation methods and immunogenicity of Bacillus anthracis poly-gamma-D-glutamic acid-protein conjugates 显示文摘 | Kubler-Kielb J Liu T Y Mocca C Majadly F Robbins J B and Schneerson R | 2006 | Infection and Immunity2006，74，8： | 1 |
| 7 | Impedance specifications for stable DC distributed power systems 显示文摘 | FENG X LIU J LEE F C | 2002 | IEEE Transactions on Power Electronics2002，17，2： | 1 |
| 8 | Investigation of PEG adsorption on the surface of zinc oxide nanoparticles 显示文摘 | Liu F Sheng C Han N X | 2004 | Power Technology2004，145，1： | 1 |
| 9 | Spatial and temporal variation of chlorophyll distribution and primary productivity related to chemical hydrography in the southern East China Sea显示文摘 | GONG G C LIU K K SHIAH F K | 2000 | Continental Shelf Research2000，20，： | 1 |
| 10 | In vivoFate ofUnimers and Micelles ofa Poly(ethylene glycol)-block-poly(caprolactone)Copolymer inMice Following IntravenousAdministration显示文摘 | Liu J Zeng F Allen C | 2007 | Eur J Pharm2007，65，3： | 1 |
| 11 | Advanced Materials for Energy Storage显示文摘 | LIU B C LI F MA L P | 2010 | Adv Mater2010，22，： | 1 |
| 12 | Proteome analysis of human liver carcinoma Huh7 cells harboring hepatitis C virus subgenomic replicon显示文摘 | Fang C Yi Z Liu F Lan S Wang J Lu H Yang P Yuan Z | 2006 | Proteomics2006，6，2： | 1 |
| 13 | A distributed class-based alternative routing and a congestion control architecture for LEO satellite networks 显示文摘 | Huang C Liu F L | 2011 | International Journal of Wireless Communications and Networking2011，3，2： | 1 |
| 14 | Protective effect of breviscapineon ischemic vascular dementia in rats显示文摘 | Xiong Z Liu C Wang F | 2006 | Biol Pharm Bull2006，29，9： | 1 |
| 15 | Characterization and expression of a new subfamily member of penaeidin antimicrobial peptides(penaeidin5)from Fenneropenaeus chinensis显示文摘 | Kang C J Xue J F Liu N | 2007 | Molecular Immunology2007，44，7： | 1 |
| 16 | Homogeneous modification of cellulose with succinic anhydride in ionic liquid using4-dimethylaminopyridine as a catalyst显示文摘 | Li W Y Liu C F Sun R C | 2009 | Carbohydrate Polymers2009，78，3： | 1 |
| 17 | Expression and localization of human lysozyme in the endosoerm of transgenic rice 显示文摘 | YANG D C GUO F L Liu B | 2003 | Planta2003，216，： | 1 |
| 18 | Vision-based measurement of weld pool geometry in constant-current gas tungsten arc welding显示文摘 | Wu C S Gao J Q Liu X F | 2003 | Proceedings of the Institution of Mechanical Engineers Part B: Journal of Engineering Manufacture2003，217，6： | 1 |
| 19 | Overexpression of cyclooxygenase-2 is suffeicient to induce tumorigenesis in transgenic mice显示文摘 | Liu C H Chang S H Joarder F S | 2001 | J Boil Chem2001，267，18： | 1 |
| 20 | High-temperature magnetic properties and microstructural analysis analysis of Sm(Co,Fe,Cu,Zr)z permanent magnets 显示文摘 | Liu J F Zhang Y Hadjipanayis G C | 1999 | Journal of Magnetism and Magnetic Materials1999，202，4： | 1 |
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