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| 1 | Expression and anti-apoptotic mechanism of Spodoptera littoralis Nucleopolyhedrovirus P49 protein显示文摘A novel cloned Spodoptera littoralis Nucleo-polyhedrovirus (SINPV) p49 gene is able to suppress apop-tosis of insect cells Sf9 triggered by virus. The amino acid sequence of P49 expressed in baculovirus expression system is the same as predicted, indicating that the expression of P49 is correct. Metabolic labeling revealed that p49 was able to be expressed both in the early and late phases after the viral infection, and only in the late phase was the expression driven by polyhedra promoter, but the amount of expression was higher than that of wtSlNPV. In summary, the early gene of SINPV p49 as well as p35 of AcMNPV is able to be expressed in the late phase, but its promoter is weaker compared with polyhedra promoter. In vitro, P49 can be cut by Bm caspase and human caspase-3, yielding 10 and 40 ku fragments. Purified P49 blocks the substrate cleavage by Bm caspase and human caspase-3, showing that P49 inhibits downstream caspases in the apoptotic pathway. | Pei, ZF Qi, YP Liu, YL Xiao, HZ | 2002 | Chinese Science Bulletin2002，47，8： | 2 |
| 2 | Cloning and identification of an angiostatic molecule IP-10/crg-2显示文摘AIM To obtain human and murine cDNAsencoding IFN--y inducible protein 10 (lP--10) andcytokine responsive gene--2 (Crg-2).METHODS The encoding genes of lP-10 and Crg2 were amplified by RT--PCR from Cultured humanfibroblast cells and Balb/ c mouse liver treatedby IFN-y and TNF-a, respectively, and clonedinto plasmids of PUC19 and PGEM3Zf(+ ).RESULTS The nucleotide sequences ot theamplified DNA were confirmed by endonucleasesdigestion and sequencing.CONCLUSION Recombinant lP-10/ crg--2 geneclones with 306 hp and 314 hp inserts wereestablished for further research on biologicalactivities and ligands of hiP-10/mCrg--2. | Liu ZG Yang JH An HZ Wang HY He FT Han ZY Han Y Wu HP Xiao B Fan DM | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 3 | Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients显示文摘 | Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 4 | Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcino -ma显示文摘 | Lee HZ Hsu SL Liu MC | 2001 | Eur J Pharmacology2001，431，3： | 1 |
| 5 | Epithelial neutrophil-activating peptide-78 recruits neutrophils into pleural effusion显示文摘 | Liu GN Shi HZ Xie ZH | | 0，，01： | 1 |
| 6 | Lcarnitine as an adjunct therapy to percutaaeous coronary intervention for non-ST elevation myocardial infarction 显示文摘 | Xue YZ Wang LX Liu HZ | 2007 | Cardiovasc Drugs Ther2007，21，6： | 1 |
| 7 | Gelatin-stabilised microemulsionbased organogels facilitates percutaneous penetration of Cyclosporin A in vitro and dermal pharmacokinetics in vivo显示文摘 | Liu HZ Wang YJ Han F | 2007 | J Pharm Sci2007，96，11： | 1 |
| 8 | Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma显示文摘 | Lee HZ Hsu SL Liu MC | 2001 | Eur J Pharmacol2001，431，3： | 1 |
| 9 | Delay analysis in practical wireless net-workcoding显示文摘 | LI HZ LIU X HE W B | 2014 | Wireless Communications and Mobile Computing2014，14，： | 1 |
| 10 | Epithelial neutrophil-activating pep- tide-78 recruits neutrophils into pleural effusion 显示文摘 | Liu GN Shi HZ Xie ZH | 2009 | Eur Respir J2009，34，1： | 1 |
| 11 | BCL 10 gene mutation in lymphoma显示文摘 | Du MQ Peng Hz Liu HX | 2000 | Blood2000，95，9： | 1 |
| 12 | Hydration and conformation of temperature- dependent micellization of PEO-PPO- PEO block copolymers in aqueous solutions by FT- Raman显示文摘 | Guo C Wang J Liu HZ Chen J Y | 1999 | Langmuir1999，15，： | 1 |
| 13 | Effect of inhaled Interleukin 5 on airway hyperreactivity and cosi- nophilia in asthmatics显示文摘 | Shi HZ Xiao CQ Zhong D Qin SM Liu Y Liang GR | 1998 | Am J Respir Crit Care Med1998，157，： | 1 |
| 14 | Oxaliplatin long - circulating liposomes improved therapeutic index of colorectal carcinlma显示文摘 | Yang C Liu HZ Fu ZX | 2011 | BMC Biotechnology2011，11，： | 1 |
| 15 | Targeting TLR2 attenuates pulmonary inflammation and fibrosis by reversion of suppressive immune microenvironment 显示文摘 | Yang HZ Cui B Liu HZ | 2009 | J Immunol2009，182，： | 1 |
| 16 | Distribution and chemical coding of corticotropin-releasing factor-immunoreactive neurons in the guinea pig enteric nervous system 显示文摘 | Liu S Gao N Hu HZ et a1 | 2006 | J Comp Neurol2006，494，1： | 1 |
| 17 | Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera显示文摘 | Ye M Guo HZ | 2005 | Rapid Commun Mass Spectrom2005，19，： | 1 |
| 18 | Identification of two critical amino acid res- idues of the severe acute respiratory syndrome coronavirus spike protein for its variation in zoonotic tropism transition via a double substitution strategy 显示文摘 | Qu XX Hao P Song XJ Jiang SM Liu YX Wang PG Rao X Song HD Wang SY Zuo Y Zheng AH Luo M Wang HL Deng F Wang HZ Hu ZH Ding MX Zhao GP Deng HK | 2005 | J Biol Chem2005，280，29： | 1 |
| 19 | PEG-liposomal oxaliplatin induces apop-tosis in human colorectal cancer cells via Fas/FasL and caspase-8显示文摘 | Yang C Liu HZ Fu ZX | 2012 | Cell Biol Int2012，36，： | 1 |
| 20 | Association of lipoprotein-associated phospholipase A2with characteristics of vulnerable coronary atherosclerotic plaques显示文摘 | Liu YS Hu XB Li HZ | 2011 | Yonsei Med J2011，52，6： | 1 |
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