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| 1 | Up-regulation of PIK3CA promotes metastasis in gastric carcinoma显示文摘AIM:To explore expressions of PIK3CA in the progression of gastric cancer from primary to metastasis and its effects on activation of phosphatidylinositol 3-kinase(PI3K)/Akt pathway.METHODS:mRNA and protein levels of PIK3CA were assessed,respectively,by real-time quantitative polymerase chain reaction and immunohistochemistry in specimens of normal gastric mucosa,primary foci and lymph node and distant metastasis of gastric cancer.Akt and phosphorylated Akt protein were also examined by Western blotting in these tissues,in order to analyze the effect of PIK3CA expression level changes on the activation of PI3K/Akt signaling pathway.RESULTS:PIK3CA mRNA in lymph node metastasis were approximately 5 and 2 folds higher,respectively,than that in the corresponding normal gastric mucosa and primary gastric cancer tissues(P<0.05),while no statistical significance was found compared with distant metastasis.Immunohistochemically,PIK3CA protein expression was discovered in 7(35%)specimens of 20 primary foci vs 10(67%)of 15 of lymph node metastasis or 11(61%)of 18 of distant metastasis(35%vs 67%,P=0.015;35%vs 61%,P=0.044).With the increased level of PIK3CA expression,the total Akt protein expression remained almost unchanged,but p-Akt protein was upregulated markedly.CONCLUSION:Increased expression of PIK3CA is expected to be a promising indicator of metastasis in gastric cancer.Up-regulation of PIK3CA may promote the metastasis of gastric cancer through aberrant activation of PI3K/Akt signaling. | Liu JF Zhou XK Chen JH Yi G Chen HG Ba MC Lin SQ Qi YC. | 2010 | World Journal of Gastroenterology2010，16，39： | 20 |
| 2 | 急性缺血性脑卒中后低脉压与不良预后相关显示文摘众所周知,脉压与心脏功能、动脉僵硬度、体液状态和血管事件有关。该研究旨在探讨基于中国台湾地区脑卒中登记资料的急性缺血性脑卒中(acute ischemic stroke,AIS)患者入院时脉压的预后作用。 | 刘莉 叶鹏 Tang SC Yin JH Liu CH Sun MH Lee JT Sun Y Hsu CS Sun MC Lin CH Chen CH Lien LM Muo CH Jeng JS Hsu CY | 2017 | 中华高血压杂志2017，25，7： | 5 |
| 3 | 颈动脉硬化进展与病程≥10年的高血压治疗之间的关系:多种族动脉粥样硬化研究显示文摘尚未有前瞻性多种族队列对抗高血压药物类别和动脉硬化进展的相关性进行研究。该研究所有受试者基线均患高血压,定义为血压≥140/90 mm Hg(1mm Hg=0.133kPa)或服用降压药物治疗。在5个时间点评估药物的服用情况和血压水平。通过超声在基线时和平均随访(9.4±0.5)年后测定右颈总动脉的杨氏弹性模量和扩张系数。 | Gepner AD Tedla Y Colangelo LA Tattersall MC Korcarz CE Kaufman JD Liu K Burke GL Shea S Greenland P Stein JH 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 2 |
| 4 | Biodegradation kinetics and microbial communities associated with methyl tert-butyl ether removal in a biotrickling filter显示文摘 | Lin CW Lin NC Liu MC | 2007 | 中国生物学文摘2007，21，7： | 2 |
| 5 | Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcino -ma显示文摘 | Lee HZ Hsu SL Liu MC | 2001 | Eur J Pharmacology2001，431，3： | 1 |
| 6 | Iavolvement of cyclin-dependent kinase activities in CD437-induced apoptosis显示文摘 | Hsu SL Yin SC Liu MC | 1999 | Exp Cell Res1999，2，252： | 1 |
| 7 | An outbreak of coxsackievirus A6 hand, foot, and mouth disease associated with onychomadesis in Taiwan, 2010显示文摘 | Wei SH Huang YP Liu MC | 2011 | BMC Infect Dis2011，11，： | 1 |
| 8 | An outbreak of coxsackievir- us A6 hand, foot, and mouth disease associated with onychomade sis in Taiwan, 2010显示文摘 | Wei SH Huang YP Liu MC | 2011 | BMC Infect Dis2011，11，： | 1 |
| 9 | Phase Ⅱ trial of lapatine for brain metastases in patients with human epidermal growth factor receptor-2 positive with breast cancer 显示文摘 | Lin NU Carey LA Liu MC | 2008 | J Clin Oncol2008，26，12： | 1 |
| 10 | Ageneral MPCCmodel and itssolution algorithm for continuous network design problem显示文摘 | Ban X Liu H Ferris MC Ran B | 2006 | Mathematicaland Computer Modeling2006，43，56： | 1 |
| 11 | Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER-2-negative advanced breast cancer显示文摘 | Barrios CH Liu MC Lee SC | 2010 | Breast Cancer Res Treat2010，121，1： | 1 |
| 12 | The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion显示文摘 | Liu M Sakamaki T Casimiro MC | | 0，，24： | 1 |
| 13 | Association of vitamin D and antimicrobial peptide production during late-phase allergicresponses in the lung显示文摘 | Liu MC Xiao HQ Brown AJ | 2012 | Clin Exp Allergy2012，42，3： | 1 |
| 14 | Is aggressive surgery necessary for acute postoperative deep spinal wound infection? 显示文摘 | Hong HS Chang MC Liu CL | 2008 | Spine( Phila Pa 1976 )2008，33，22： | 1 |
| 15 | Does ostoperative pain in- duce emesis?显示文摘 | CHIA YY KUO MC LIU L | 2002 | Clin J Pain2002，18，5： | 1 |
| 16 | Abnormality of CD4^(+) CD25^(+) regulatory T cells in idiopathic thrombocytopenic purpura显示文摘 | Liu B Zhao H Poon MC | 2007 | Eur J Haematol2007，78，2： | 1 |
| 17 | Optimal beam design on in- tensity modulated radiation therapy with simultaneous integrated boost in nasopharyngeal cancer显示文摘 | Cheng MC Hu YW Liu CS | 2014 | Med Dosim2014，39，3： | 1 |
| 18 | Phase Ⅱ trial of lapa- tinib for brain metastases in patients with HER2-positive breast cancer显示文摘 | Lin NU Carey LA Liu MC | 2006 | J Clin Oncol2006，24，318： | 1 |
| 19 | Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma显示文摘 | Lee HZ Hsu SL Liu MC | 2001 | Eur J Pharmacol2001，431，3： | 1 |
| 20 | Abnormality of CD4+CD25+regulatory T cell in idiopathic thrombocytopenic purpura显示文摘 | Liu B Zhan H Poon MC | 2007 | Eur J Haematol2007，78，2： | 1 |
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