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| 1 | Dynamic Recrystallization Behavior of a Heat-resistant Martensitic Stainless Steel 403Nb during Hot Deformation显示文摘Dynamic recrystallization(DRX) behaviors of a heat-resistant martensitic stainless steel 403Nb during hot deformation have been investigated by single-pass thermo-mechanical simulative experiment at temperatures of 900-1150 C and strain rates of 0.01-1 s 1.The results show that the true stress-true strain curves of this alloy can be classified into two types,one is of dynamic recovery and the other is of dynamic recrystallization.The DRX in 403Nb alloy is easy to occur at strain rates lower than 0.5 s 1 and deformation temperatures higher than 1000 C.Using regression analysis,the stress multiplier(α) and apparent stress exponent(n) were calculated to be 0.0153 and 3.22,respectively,while the activation energy(Q d) for DRX of 403Nb was calculated to be 367.293 kJ/mol.The constitutive equation of peak stress for DRX was also obtained.Based on P-J method,the critical strain for DRX was accurately determined.The mathematical models of peak strain and kinetic equation for DRX of 403Nb steel were finally established. | Zhouyu Zeng Liqing Chen Fuxian Zhu Xianghua Liu | 2011 | Journal of Materials Science & Technology2011，27，10： | 12 |
| 2 | An enhanced method for nucleic acid detection with CRISPR-Cas12a using phosphorothioate modified primers and optimized gold-nanopaticle strip显示文摘CRISPR-Cas12a system has been shown promising for nucleic acid diagnostics due to its rapid,portable and accurate features.However,cleavage of the amplicons and primers by the cis-and trans-activity of Cas12a hinders the attempts to integrate the amplification and detection into a single reaction.Through phosphorothioate modification of primers,we realized onepot detection with high sensitivity using plasmids of SARS-CoV-2,HPV16 and HPV18.We also identified the activated Cas12a has a much higher affinity to C nucleotide-rich reporter than others.By applying such reporters,the reaction time required for a lateral-flow readout was significantly reduced.Furthermore,to improve the specificity of the strip-based assay,we created a novel reporter and,when combined with a customized gold-nanopaticle strip,the readout was greatly enhanced owing to the elimination of the nonspecific signal.This established system,termed Targeting DNA by Cas12a-based Eye Sight Testing in an Onepot Reaction(TESTOR),was validated using clinical cervical scrape samples for human papillomaviruses(HPVs)detection.Our system represents a general approach to integrating the nucleic acid amplification and detection into a single reaction in CRISPR-Cas systems,highlighting its potential as a rapid,portable and accurate detection platform of nucleic acids. | Jiaojiao Gong Lijuan Kan Xiuming Zhang Ying He Jiaqiang Pan Liping Zhao Qianyun Li Menghao Liu Jie Tian Sili Lin Zhouyu Lu Liang Xue Chaojun Wang Guanghui Tang | 2021 | Bioactive Materials2021，6，12： | 1 |
| 3 | A new three-dimensional method of character- istics for neutron transport calculation显示文摘 | LIU Zhouyu WU Hongchun CAO Liangzhi | 2011 | An- nals of Nuclear Energy2011，38，： | 1 |
| 4 | Static recrystallization behavior of a martensitic heat-resistant stainless steel 403Nb显示文摘A static recrystallization behavior between the rolling passes of a martensitic heat-resistant stainless steel 403Nb has been studied by OM,TEM and double-hit thermo-mechanical simulator to explore the effects of deformation temperature,strain rate,strain and the prior austenite grain size. The results show that increases of deforma-tion temperature and strain rate and strain can promote the static recrystallization of 403Nb steel. Static recrystallization also proceeds faster when the prior austenite grain size is smaller. Microstructural observation indicates that the volume fraction of static recrystallization increases with prolonged interval of the rolling passes. Strain-induced precipitation can lead to an appearance of a platform in the kinetic curve of static recrystallization. Different from the conventional micro-alloying steel,the strain-induced precipitates in 403Nb steel during hot rolling are carbides containing Nb and Cr. | Zhouyu ZENG Liqing CHEN Fuxian ZHU Xianghua LIU | 2011 | Acta Metallurgica Sinica(English Letters)2011，24，5： | 0 |
| 5 | Red/NIR emission carbonized polymer dots based on citric acid-benzoylurea and their application in lymph nodes imaging显示文摘Identification of lymph nodes(LNs)is critical for studies of the structure,the role in disease development,and the efficacy of disease treatment.Carbonized polymer dots(CPDs)are expected to be potential LNs-targeted imaging agents due to their excellent properties with special structure,better photoluminescence(PL)and great biocompatibility.Herein,a red/near infrared(NIR)emission CPDs(RCPDs)with one and two-photon bioimaging based on citric acid(CA)and benzoylurea(BU)are prepared.Notably,the RCPDs are capable of targeting LNs for imaging.Lymphocyte homing has been demonstrated to be the cellular mechanism of RCPDs target LNs imaging.This work has developed a new nanomaterial for targeted imaging of LNs,while the biological applications of CPDs have been expanded and deepened. | Feishi Shan Tingrui Zhang Chengshuang Liao Xue Yue Jing Zhang Li Yan Yanman Liu Zhixing Cao Min Wang Yahui Zhang Leyong Wang Zhouyu Wang Xiaoqi Yu | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 6 | Association between IDEAL-IQ MRI fat fraction quantification and pelvic bone marrow reserve function in concurrent chemoradiotherapy for cervical cancer显示文摘Objective:To analyze the association between iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantification sequence(IDEAL-IQ)magnetic resonance imaging(MRI)of bone marrow fat fraction and bone marrow reserve function during concurrent chemoradiotherapy for cervical cancer.Methods:The study retrospectively analyzed twenty-six patients with stage IB1 to IVA cervical cancer treated between February 2020 and November 2020.All patients received concurrent chemoradiotherapy that included platinum alone or combined paclitaxel and platinum.Pelvic IDEAL-IQ MRI(plain and enhanced)was performed before and after treatment.Regions of interest,including the fifth lumbar vertebra,sacrum,ilium,ischium,and femoral neck,were manually delineated,and the bone marrow fat fraction was measured.Peripheral blood cell counts were recorded during treatment,and the relationship between the fat fraction values and changes in the blood cell counts was explored.Results:IDEAL-IQ MRI bone marrow fat fraction was associated with platelet nadir and platelet decline during treatment.The average pelvic bone marrow fat fraction before chemoradiotherapy was moderately negatively correlated with platelet count nadir during concurrent chemoradiotherapy(r=-0.450,P?0.021).The change in average pelvic bone marrow fat fraction through chemoradiotherapy was moderately positively correlated with the degree of thrombocytopenia(r=0.399,P=0.044).Conclusion:Bone marrow fat content quantified by IDEAL-IQ was associated with platelet count nadir and the degree of thrombocytopenia in patients with cervical cancer undergoing concurrent chemoradiotherapy. | Xiaomin Wen Qinghua Qin Yanling Wu Zhouyu Li Xinglong Yang Jinquan Liu Ling Lin Mingyi Li | 2023 | Radiation Medicine and Protection2023，4，3： | 0 |
| 7 | Corrigendum to“One-pot tandem route to fused indolizidines and quinolizidines:Application in the synthesis of alkaloids and bioactive compounds”[Chinese Chemical Letters 32(2021)1713-1716]显示文摘The authors regret that an interesting work about amide activation left uncited in the above-titled publication.An corrigendum is given as follows:In 2017,Huang’s group[1]reported an interesting method consisting of the amide activation(Tf_(2)0)induced dehydracoupling of halo-genated secondary amides with alkenes and NaBH4 reduction triggered tandem cyclization reaction.It is an efficient strategy to construct substituted pyrrolidine,piperidine,indolizidine,quinolizidine ring systems,and enimino carbocycles. | Qiao Song Yan Liu Linlin Cai Xinyu Cao Shan Qian Zhouyu Wang | 2022 | Chinese Chemical Letters2022，33，4： | 0 |
| 8 | One-pot tandem route to fused indolizidines and quinolizidines:Application in the synthesis of alkaloids and bioactive compounds显示文摘Fused indolizidines and quinolizidines are important skeletons in a variety of natural products and pharmacologically important compounds.A one-pot tan dem route from amide to fused indolizidines and quinolizidines is disclosed.This method is con ducted in mild conditions and shows well tolerance of functional groups.It is also easy to be scaled up to gram scale and can be applied smoothly to the total synthesis of alkaloids such as(±)-crispine A,(±)-xylopinine,(±)-desbromoarborescidine A,(±)-harmicine and other bioactive substances. | Qiao Song Yan Liu Linlin Cai Xinyu Cao Shan Qian Zhouyu Wang | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
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