| 1 | Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism显示文摘Depression is a mental disorder with high morbidity,disability and relapse rates.Ginkgo biloba extract(GBE),a traditional Chinese medicine,has a long history of clinical application in the treatment of cerebral and mental disorders,but the key mechanism remains incompletely understood.Here we showed that GEB exerted anti-depressant effect in mice through regulating gut microbial metabolism.GBE protected against unpredictable mild stress(UMS)-induced despair,anxiety-like and social avoidance behavior in mice without sufficient brain distribution.Fecal microbiome transplantation transmitted,while antibiotic cocktail abrogated the protective effect of GBE.Spatiotemporal bacterial profiling and metabolomics assay revealed a potential involvement of Parasutterella excrementihominis and the bile acid metabolite ursodeoxycholic acid(UDCA)in the effect of GBE.UDCA administration induced depression-like behavior in mice.Together,these findings suggest that GBE acts on gut microbiome-modulated bile acid metabolism to alleviate stress-induced depression. | ZHOU Junchi FAN Qilin CAI Xiaoying ZHANG Youying HOU Yuanlong CAO Shuqi LIZiguang FENG Mengzhen WANG Qingqing ZHANG Jianbing WANG Guangi ZHENG Xiao HAO Haiping | 2023 | Chinese Journal of Natural Medicines2023，21，10： | 0 |
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