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| 1 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 2 | Partial sequencing of 5' non-coding region of 7 HGV strains isolated from different areas of China显示文摘 | WANG Xing-Tai ZHUANG Hui SONG Hai-Bo Ll He-Min ZHANG Hua-Yuan and YU Yang(National Institute for the Control of bormceutical and BiologicalPriducts, Beijing 100050, China)(Department of Microbiology, Beijing Medical University, Beijing100083, China)(L | 1999 | World Journal of Gastroenterology1999，5，5： | 7 |
| 3 | Efficacies of β-L-D4A against Hepatitis B virus in 2.2.15 cells显示文摘AIM:To investigate the antiviral effect of beta-L-enantiomer of 2',3'-didehydro-2',3'-dideoxyadenosine (β-L-D4A) on 2.2.15 cells transfected with the hepatitis B virus (HBV) genome. METHODS:Lamivudine (3TC) as a positive control. Then, HBV DNA in treated 2.2.15 cells and the Hepatitis B surface antigen (HBsAg) in the culture supernatants were detected to determine the inhibitory effect of β-L-D4A. At the same time, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) was used to detect the survival ratio of 2.2.15 cells. RESULTS:β-L-D4A has a dose-dependent inhibitory effect on HBV DNA replication;this effect was apparent when the concentration was above 1 mol/L. When β-L-D4A was at the highest concentration, 100 mol/L, the HBsAg inhibition ratio was above 50%. The Therapeutic index (TI) of β-L-D4A was above 2.1. CONCLUSION:β-L-D4A has a dose-dependent inhibitory effect on the replication of HBV DNA and the secretion of HBsAg at low toxicity. | Lin-Lin Gao, Xiao-Yan Wang, Ju-Sheng Lin, Ying-Hui Zhang, Yan Li, Institute of Liver Diseases, Tongji Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China Author contributions:Gao LL and Wang XY contributed equally to this work Gao LL, Wang XY, Lin JS, Zhang YH, Li Y designed the research Gao LL and Wang XY performed the research Gao LL wrote the paper | 2008 | World Journal of Gastroenterology2008，14，8： | 7 |
| 4 | Soil fungistasis and its relations to soil microbial composition and diversity:A case study of a series of soils with different fungistasis显示文摘Fungistasis is one of the important approaches to control soil-borne plant pathogens.Some hypotheses about the mechanisms for soil fungistasis had been established,which mainly focused on the soil bacterial community composition,structure,diversity as well as function.In this study,the bacterial community composition and diversity of a series of soils treated by autoclaving,which coming from the same original soil sample and showing gradient fungistasis to the target soil-borne pathogen fungi Fusarium gr... | Wu Minna Zhang Huiwen Ll Xinyu Zhang Yan Su Zhencheng Zhang Chenggang | 2008 | Journal of Environmental Sciences2008，20，7： | 7 |
| 5 | GSPAC water movement in extremely dry area显示文摘Under an extremely arid condition,a PVC greenhouse was built on the top of Mogao Grottoes in gobi area.The results of 235-day constant extraction of condensed water on the greenhouse film and soil water content showed that 2.1 g/(m2·d) groundwater moved up and exported into the soil,and a phreatic water evaporation existed in the extreme dry area where the groundwater is buried deeper than 200 m.After a prolonged export,the soil water content in the greenhouse was not lower but obviously higher than the original control ones.According to the monitored parameters including relative humidity and absolute humidity of soil,and temperature outside and inside the greenhouse,it was found that there is the available condition and mechanism for the upward movement of groundwater,and also it can be sure that the exported water was not from the soil and atmosphere outside the greenhouse.Phreatic water,an important source for soil water,interacts with atmosphere moisture via soil respiration.Soil salinity also has important effects on soil water movement and spatial-temporal heterogeneity.The extremely dry climate,terrestrial heat and change of upper soil temperature are the fundamental driving forces of water transportation and phreatic water evaporation in the Groundwater-Soil-Plant-Atmosphere Continuum(GSPAC) system. | HongShou Ll WanFu WANG GuoBin ZHANG ZhengMo ZHANG XiaoWei WANG | 2011 | Journal of Arid Land2011，3，2： | 4 |
| 6 | SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS显示文摘SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS￥TaiBaoWEI;JiChouCHEN;YouMing... | Wei, TB Chen, JC Zhang, YM Wang, LL | 1995 | Chinese Chemical Letters1995，6，3： | 4 |
| 7 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 8 | SELECTIVE DIMERIZATION OF BUTANAL TO BUTYL BUTYRATE CATALYZED BY LANTHANOCENE/n-BuLi SYSTEMS显示文摘SELECTIVEDIMERIZATIONOFBUTANALTOBUTYLBUTYRATECATALYZEDBYLANTHANOCENE/n-BuLiSYSTEMS￥FanXU,LiLuZHANG,MingYAO,YuanChenDING,ZhiMi... | Xu, F Zhang, LL Yao, YM Ding, YC Bai, ZM Shen, Q | 1995 | Chinese Chemical Letters1995，6，7： | 2 |
| 9 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 10 | Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer's disease显示文摘 | Wei LL Shen YD Zhang YC | 2010 | Neurosci Bull2010，26，1： | 1 |
| 11 | LCRGI suppresses tumor growth in vivo by liposome-mediated gene transfer 显示文摘 | Ll Y J ZHANG X P CHEN Z C | 2002 | Chin J Cancer Res2002，14，2： | 1 |
| 12 | A multivariable generalized predictive control approach based on T-S fuzzy model 显示文摘 | Zhang H G Cai LL Bien Zeungnam | 2000 | Journal of Intelligent & Fuzzy System: Applications in Engineering And Technology (S 1064-1246)2000，9，34： | 1 |
| 13 | Inhibition of Adipogenesis by Ghrelin显示文摘 | Zhang WZ Zhao LL Lin TR et al | 2004 | Molecular Biology of the Cell2004，15，5： | 1 |
| 14 | Chromatographic Fingerprinting Analysis of Danshen Root (Salvia Miltiorrhiza Radix et Rhizoma) and Its Preparations Using High Performance Liquid Chromatography with Diode Array Detection and Electro?spray Mass Spectrometry (HPLC-DAD-ESIIMS)显示文摘 | LlU M Ll Y G ZHANG Fver al | 2007 | ] Sep Sci2007，30，： | 1 |
| 15 | MiR-499 induces cardiac differentiation of rat mesenchymal stem cells through wnt/β-catenin signaling pathway显示文摘 | Zhang LL Liu J J Liu F | 2012 | Biochem Biophys Res Commun2012，420，4： | 1 |
| 16 | Changes of adiponectin and in- flammatory cytokines after periodontal intervention in type 2 diabe- tes patients with periodontitis显示文摘 | Sun WL Chen LL Zhang SZ | 2010 | Arch Oral Biol2010，55，12： | 1 |
| 17 | Features of airway re- modeling in different types of Chinese chronic rhinosinus- itis are associated with inflammation patterns显示文摘 | Shi LL Xiong P Zhang L | 2013 | Aller- gy2013，68，1： | 1 |
| 18 | Estrogen-induced alnormally high CFTR expression results in ovarian hyperstimulation syndrome显示文摘 | Ajonuma LC Tsang LL Zhang GH | 2005 | Mol Endocrinol2005，19，12： | 1 |
| 19 | Overexpression of CC3/TIP30 is associated with HER-2/neu status in breast cancer显示文摘 | Zhang DH Wong LL Tai LK | 2005 | Cancer Res Cli Oncol2005，，9： | 1 |
| 20 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
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