|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Etiopathogenesis of primary biliary cirrhosis显示文摘Primary biliary cirrhosis(PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure.The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies(AMA).These reflect the presence of autoreactive T and B cells to the culprit antigens,the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes,chiefly pyruvate dehydrogenase(PDC-E2).The disease results from a combination of genetic and environmental risk factors.Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins.Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing,after a long latency,the emergence of clinical disease.Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or,alternatively,environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic.A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells.In the effector phase the biliary ductular cell,by reason of itsproclivity to express the antigen PDC-E2 in the course of apoptosis,undergoes a multilineage immune attack comprised of CD4+ and CD8+ T cells and antibody.In this article,we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data,new developments and theories,and nominate directions for future research. | Ana Lleo Pietro Invernizzi Ian R Mackay Harry Prince Ren-Qian Zhong M Eric Gershwin | 2008 | World Journal of Gastroenterology2008，14，21： | 9 |
| 2 | Interpreting serological tests in diagnosing autoimmune liver diseases显示文摘 | Invernizzi P Lleo A Podda M | 2007 | Semin Liver Dis2007，27，： | 1 |
| 3 | gamma-Secretase as a therapeutic target in Alzheimer's disease 显示文摘 | GUARDIA-LAGUARTA C PERA M LLEO A | 2010 | Curt Drug Targets2010，11，4： | 1 |
| 4 | Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032) 显示文摘 | Canepari P Boaretti M Lleo MM | 1990 | Antimicrob Agents Chemother1990，34，6： | 1 |
| 5 | Epigenetic investigation of variabty X chromosome inactivated genes in monozygotic female twins discordant for primary biliary cirrhosis 显示文摘 | MITCHELL M M LLEO A ZAMMATARO L | 2011 | Epigenetics2011，6，1： | 1 |
| 6 | HLA class II antigens associated with lupus nephritis in Italian SLE patients显示文摘 | Marehini M Antonioli R Lleo A | 2003 | Hum Immunol2003，64，： | 1 |
| 7 | Interpreting serologi-cal tests in diagnosing autoimmune liver disease显示文摘 | Invernizzi P Lleo A Podda M | 2007 | Semin Liver Dis2007，27，2： | 1 |
| 8 | The relationship between central corneal thickness and Goldmann applanation tonometry显示文摘 | Lleo A Marcos A Calatayud M Alonso L Rahhal SM Sanchis-Gimeno JA | 2003 | Clin Exp Optom2003，86，2： | 1 |
| 9 | Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases显示文摘 | Lleo A Galea E Sastre M | 2007 | Cell Mol Life Sci2007，64，11： | 1 |
| 10 | Current pharmaco- therapy for alzheimer' s disease 显示文摘 | Lleo A Greenberg S M Growdon J H | 2006 | Annual Review of Medicine2006，57，： | 1 |
| 11 | Genetics and epigenetics of primarybiliary cirrhosis显示文摘 | Bianchi I Carbone M Lleo A | 2014 | Semin Liver Dis2014，34，3： | 1 |
| 12 | Current pharmacotheraph for Alzheimer's disease显示文摘 | Lleo A Greenberg S M Growdon J H | 2006 | Annu Rev Med2006，57，： | 1 |
| 13 | HLA class Ⅱ antigens associated with lupus nephritis in Italian SLE patients显示文摘 | Marchini M Antonioli R Lleo A | 2003 | Hum Immunol2003，64，4： | 1 |
| 14 | A Satellite Infrastructure for Health Early Warning in Post - disaster Health Management 显示文摘 | Chronaki CE Berthier A Lleo MM Esterle L Lenglet A Simon F Josseran L Lafaye M Matsakis Y Tabasco A Braak L | 2007 | Medinfo2007，12，1： | 1 |
| 15 | The relationship between central corneal thickness and Goldmann applanation tonometry 显示文摘 | Lleo A Marcos A Calatayud M | 2003 | Clin Exp Optom2003，2，： | 1 |
| 16 | Interpreting serological tests in diagnosing autoimmune liver diseases显示文摘 | Invernizzi P Lleo A Podda M | | 0，，02： | 1 |
| 17 | Interpreting serological tests in diagnosing autoimmune liver diseases显示文摘 | Invernizzi P Lleo A Podda M | 2007 | Semin Liver Dis2007，27，2： | 1 |
| 18 | Monitoring spinach shelf-life with hyperspectral image through packaging films 显示文摘 | LARA M A LLEO L DIEZMA-IGLESIAS B | 2013 | Journal of Food Engineering2013，119，2： | 1 |
| 19 | Genetics and epigenetics of pri- mary biliary cirrhosis显示文摘 | Bianchi I Carbone M Lleo A | 2014 | Semin Liver Dis2014，34，3： | 1 |
| 20 | Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases显示文摘 | Lleo A Galea E Sastre M | 2007 | Cell Mol Life Sci2007，64，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员