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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | A Stiffness analysis for CaPaMan (Cassino Parallel Manipulator)显示文摘 | CECCARELLI M CARBONE G | 2002 | Mechanism and Machine Theory2002，37，： | 1 |
| 3 | Fluoroscopically assisted pedicle screw fixation for thoracic and thoracolumbar injuries显示文摘 | John J Carbone M D Justin P | 2003 | SPINE2003，28，1： | 1 |
| 4 | Systemic and topical corticosteroid treatment of oral lichen planus:a comparative study with long-term follow-up显示文摘 | Carbone M Goss E Carrozzo M | 2003 | J Oral Pathol Med2003，32，： | 1 |
| 5 | Antioxidant en- zymatic defences in human follicular fluid: Characterization and age-dependent changes 显示文摘 | Carbone M C Tatone C Delle Monache S | 2003 | Molecular Human Reproduction2003，9，11： | 1 |
| 6 | A model to predict peach phenology and maturity using meteorolgical variables显示文摘 | Schwartz M D Carbone G J Reighard G L | | 0，，02： | 1 |
| 7 | Percutaneous pinning of three-or four-part fractures of the proximal humerus in elderly patients in poor general condition:MIROS? versus traditional pinning显示文摘 | Carbone S Tangari M Gumina S | 2012 | Int Orthop2012，36，6： | 1 |
| 8 | Sustainable Tourism in Developing Countries: Poverty Allevia- tion, Participatory Planning, and Ethical Issues显示文摘 | Carbone M | 2005 | The European Journal of Development Research2005，17，3： | 1 |
| 9 | The changing role of ports in supply--chain management 显示文摘 | Carbone V De Martino M | 2003 | Maritime Policy and Management2003，30，4： | 1 |
| 10 | Long term follow up of video-assisted talc pleurodesis in malignant recurrent pleural effusions显示文摘 | CARDILLO G FACCIOLO F CARBONE M | 2002 | Cardio Thoracic Surgery2002，212，： | 1 |
| 11 | Help for cytotoxic-T-cell responses is mediated by CD40 signaling显示文摘 | Carbone M F R | 1998 | Nature1998，393，6684： | 1 |
| 12 | A ease of multiple myeloma with multilobulated and convoluted plasma cell muclei 显示文摘 | Grange M J Fantin B Carbon C | 1992 | Nouv Rev Fr Hematol1992，34，： | 1 |
| 13 | Anchorage of carbon nanotubes grown on carbon fibers显示文摘 | de Riccardis M F Carbone D Makris T D | 2006 | Carbon2006，44，： | 1 |
| 14 | In- creased cerebellar activation during sequence learning in DYT1 carriers: an equiperformance study显示文摘 | CARBON M GHILARDI MF ARGYELAN M | 2008 | Brain2008，131，1： | 1 |
| 15 | Chemical analysis of flavonoid constituents of the seagrass Halophila stipulacea: First finding of malonylated derivatives in marine phanerogams显示文摘 | Bitam F Ciavatta M L Carbone M | 2010 | Biochemical Systematics and Ecology2010，38，4： | 1 |
| 16 | Microwave-assisted synthesis of colloidal inorganic nanocrystals显示文摘 | Baghbanzadeh M Carbone L Cozzoli PD | 2011 | Angewandte Chemie-International Edition2011，50，11： | 1 |
| 17 | Agroforestry as sequestration 显示文摘 | Nair P K R Kumar B M a strategyfor carbon Nair V D | 2009 | Journal of Plant Nutrition and Soil Science2009，172，： | 1 |
| 18 | Inferior vena cava parameters pre- dict readmission in ischaemic heart failurea显示文摘 | Carbone F Bovio M Rosa G M | 2014 | Eur J Clin Invest2014，44，4： | 1 |
| 19 | Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk 显示文摘 | Falvella FS Galvan A Frullanti E Spinnla M Calabrb E Carbone A | 2009 | Clin Cancer Res2009，15，5： | 1 |
| 20 | The Receptor for Urokinase-type Fibroblasts显示文摘 | ELIZABETH M VERTMAN G CARBON W P | 2004 | J Biol Chem2004，279，2： | 1 |
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