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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders显示文摘 | Joan Massagué Stacy W Blain Roger S Lo | 2000 | Cell2000，，2： | 2 |
| 3 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 4 | TGF - β signaling in growth control, cancer, and heritable disorders 显示文摘 | Massague J Blain S W Lo R S | 2000 | Cell2000，103，2： | 1 |
| 5 | Real-time garbage collection for flash-memory storage systems of realtime embedded systems 显示文摘 | Chang L P Kuo T W Lo S W | 2004 | ACM Transactions on Embedded Computing Systems2004，3，4： | 1 |
| 6 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 7 | NMR properties of petroleum reservoir fluids显示文摘 | Lo S W Zhang Y | 2003 | Magnetic Resonance Imaging2003，21，： | 1 |
| 8 | Application of evolutionary neural network method in predicting pollutant levels in downtown area of Hong Kong显示文摘 | FAN H Y LO S M | 2003 | Neuro computing2003，51，1： | 1 |
| 9 | Assessment of heavy metal cations in sediments of Shing Mun River,Hang Kong显示文摘 | Chua H Lo W | 2001 | Environment International2001，26，： | 1 |
| 10 | Erythropoietin enhances endog- enous haem oxygenase-I and represses immune responses to amelio- rate experimental autoimmune encephalomyelitis 显示文摘 | Chen S J Wang Y L Lo W T | 2010 | Clin Exp Im- munol2010，162，2： | 1 |
| 11 | A strain-based design method for the collapse limit state of reinforced soil walls or slopes显示文摘 | LO S C R Xu D W | 1992 | Can Geotech J1992，29，5： | 1 |
| 12 | Low energy transfer to the moon显示文摘 | KoonWS Lo M W Marsden JE and Ross S D | 2001 | Celestial Mechanics and Dynamical Astronomy2001，9，： | 1 |
| 13 | Low energy transfer to the moon 显示文摘 | Koon W S Lo M W Marsden J E | 2001 | Celestial Mechanics and Dynamical Astronomy2001，9，： | 1 |
| 14 | Properties of SiO2-like barrier layers on polyethersulfone substrates by low-temperature plasma-enhanced chemical vapor deposition显示文摘 | Wuu D S Lo W C Chang L S | 2004 | Thin Solid Films2004，468，1： | 1 |
| 15 | Energy-efficient resource alloca- tion in multi-cell OFDMA systems with limited backhaul capacity 显示文摘 | NG D W K LO E S SCHOBER R | 2012 | IEEE Transactions on Wireless Communications2012，11，10： | 1 |
| 16 | The novel organization andcomplete sequence of the ribosomal RNA gene of Nosema bombycis显示文摘 | Huang W F Tsai S J Lo C F Y | 2004 | Fungal Genet Biol2004，41，5： | 1 |
| 17 | Physico-chemical treatment techniques for wastewater laden with heavy metals显示文摘 | KURNIAWAN T A CHAN C LO W H BABEL S | 2006 | Chemical Engineering Journal2006，118，1： | 1 |
| 18 | The flow patterns and stresses on the wall in a symmetric louvered-wall moving granular filter bed显示文摘 | Chou C S Lo W F Smid J | 2003 | Powder Technology2003，131，23： | 1 |
| 19 | Ultrasonic wire-bond quality monitoring using piezoelectric sensor显示文摘 | Or S W CHAN H L W LO V C YUEN C W | 1998 | Sensors and Actuators A: Physical1998，65，1： | 1 |
| 20 | Differential niche and Wnt requirements during acute myeloid leukemia progression显示文摘 | Lane S W Wang Y J Lo C C | 2011 | Blood2011，118，10： | 1 |
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