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| 1 | General review of magnetic resonance elastography显示文摘Magnetic resonance elastography(MRE) is an innovative imaging technique for the non-invasive quantification of the biomechanical properties of soft tissues via the direct visualization of propagating shear waves in vivo using a modified phase-contrast magnetic resonance imaging(MRI) sequence. Fundamentally,MRE employs the same physical property that physicians utilize when performing manual palpation- that healthy and diseased tissues can be differentiated on the basis of widely differing mechanical stiffness. By performing 'virtual palpation ',MRE is able to provide information that is beyond the capabilities of conventional morphologic imaging modalities. In an era of increasing adoption of multi-parametric imaging approaches for solving complex problems,MRE can be seamlessly incorporated into a standard MRI examination to provide a rapid,reliable and comprehensive imaging evaluation at a single patient appointment. Originally described by the Mayo Clinic in 1995,the technique represents the most accurate non-invasive method for the detection and staging of liver fibrosis and is currently performed in more than 100 centers worldwide. In this general review,the mechanical properties of soft tissues,principles of MRE,clinical applications of MRE in the liver and beyond,and limitations and future directions of this discipline-are discussed. Selected diagrams and images are provided for illustration. | Gavin Low Scott A Kruse David J Lomas | 2016 | World Journal of Radiology2016，8，1： | 5 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Positron emission tomography scanning in the evaluation of hepatocellular carcinoma显示文摘 | M.Akram Khan Connie S Combs Elizabeth M Brunt Val J Lowe Michael K Wolverson Harvey Solomon Brian T Collins Adrian M.Di Bisceglie | 2000 | Journal of Hepatology2000，，5： | 2 |
| 4 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 5 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 6 | The reflection of guided waves from circumferential notches in pipes 显示文摘 | Alleyne D N Lowe M J S Cawley P | 1998 | Trans ASME J of Appl Mech1998，65，： | 2 |
| 7 | Variation in open reading frames 3, 4 and 7 among porcine reproductive and respiratory syndrome virus isolates in the UK 显示文摘 | Drew T W Lowings J P Yapp F | 1997 | Vet Microbiol1997，55，14： | 1 |
| 8 | Male breast cancer 15 years after allogeneic hematopoietic cell transplantation including total body irradiation for recurrent acute lymphoblastic leukemia显示文摘 | Lowe T Luu T Shen J | 2008 | Onkologie2008，31，5： | 1 |
| 9 | Growth of anaerobic rumen fungi on defined and semi-defined media lacking rumen fluid显示文摘 | LOWE S E THEODOROU M K TRINCI A P J | 1985 | Journal of General Microbiology1985，131，： | 1 |
| 10 | Thoracic nodal staging with PET imaging with 18FDG in patients with bronchogenic carcinoma显示文摘 | Patz EF Jr Lowe V J Goodman PC | 1995 | Chest1995，108，6： | 1 |
| 11 | Pulmonary abnormalities and PET data analysis:a retrospective study显示文摘 | LOWE V J DUHAYLONGSOD F G PATZ E F | 1997 | Radiology1997，202，： | 1 |
| 12 | A novel approach to the detection of classical swine fever virus by RT-PCR with a fluorogenic probe (TaqMan) 显示文摘 | McGoldrick A Lowings J P Ibata G | 1998 | J Virol Methods1998，72，2： | 1 |
| 13 | Challenging tradition: unlocking new paths to regional industrial upgrading显示文摘 | NICHOLA J LOWE | 2009 | Environment and Planning2009，，41： | 1 |
| 14 | Guided waves in curved pipes显示文摘 | DEMMA A CAWLEY P LOWE M J S | 2002 | Review of Progress in Quantitative Nondestructive Evaluation2002，21，： | 1 |
| 15 | The ecology of the European rabbit (Oyctolagus cuniculus) in coastal southwestern Australia显示文摘 | Twigg L E Lowe T J Martin G R | 1998 | Wildl Res1998，25，： | 1 |
| 16 | The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine显示文摘 | Paraskevopoulou C Fairhurst S A Lowe D J | 2006 | Mol Microbiol2006，59，3： | 1 |
| 17 | Familial myopathy with tubular aggregates associated with abnormal pupils显示文摘 | Shahrizaila N Lowe J Wills A | 2004 | Neurology2004，63，6： | 1 |
| 18 | Trade-offs re- lated to ecosystem engineering: a case study on stiff- ness of emerging macrophytes显示文摘 | Bouma T J deVries M B LowE | 2005 | Ecology2005，86，： | 1 |
| 19 | An Investigation of the Plastic Fracture of AISI 4340 and 18Nickel -200 Grade Maraging Steels 显示文摘 | Cox T B Low J R | 1974 | Metallurgical Transac- tions1974，5，6： | 1 |
| 20 | Improvement inreporting skills of radiology residents with a structured reportingcurriculum显示文摘 | Collard MD Tellier J Chowdhury AS Lowe LH | 2014 | Acad Radiol2014，21，1： | 1 |
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