| 1 | Conceptual study of lunar-based SAR for global change monitoring显示文摘As an active microwave remote sensing imaging sensor, Synthetic Aperture Radar(SAR) plays an important role in earth observation. Here we establish a SAR system based on the platform of the moon. This will aid large-scale, constant, and long-term dynamic Earth observations to better meet the needs of global change research and to complement the space borne and airborne earth observations. Lunar-based SAR systems have the characteristics of high resolution and wide swath width. The swath width could be thousands of kilometers in the stripe mode and it could cover 40% of earth's surface with 10 meters or even higher spatial resolution in the scanning mode. Using the simplified observation model, here we quantitatively analyze the spatial resolution and coverage area of lunar-based SAR and simulate the observation on the Qinghai-Tibet plateau and the Amazon plain. The results show that this system could provide near 100% daily coverage of the Qinghai-Tibet plateau, whereas 40% to 70% daily coverage of the Amazon plain. Lunar-based SAR could provide large-scale, long-term and stable time series data in order to support future research of global change. | GUO HuaDong DING YiXing LIU Guang ZHANG DaoWei FU WenXue ZHANG Lu | 2014 | Science China Earth Sciences2014，57，8： | 8 |
| 3 | Construction of hollow polydopamine nanoparticle based drug sustainable release system and its application in bone regeneration显示文摘Nanomaterial-based drug sustainable release systems have been tentatively applied to bone regeneration.They,however,still face disadvantages of high toxicity,low biocompatibility,and low drug-load capacity.In view of the low toxicity and high biocompatibility of polymer nanomaterials and the excellent load capacity of hollow nanomaterials with high specific surface area,we evaluated the hollow polydopamine nanoparticles(HPDA NPs),in order to find an optimal system to effectively deliver the osteogenic drugs to improve treatment of bone defect.Data demonstrated that the HPDA NPs synthesized herein could efficiently load four types of osteogenic drugs and the drugs can effectively release from the HPDA NPs for a relatively longer time in vitro and in vivo with low toxicity and high biocompatibility.Results of qRT-PCR,ALP,and alizarin red S staining showed that drugs released from the HPDA NPs could promote osteogenic differentiation and proliferation of rat bone marrow mesenchymal stem cells(rBMSCs)in vitro.Image data from micro-CT and H&E staining showed that all four osteogenic drugs released from the HPDA NPs effectively promoted bone regeneration in the defect of tooth extraction fossa in vivo,especially tacrolimus.These results suggest that the HPDA NPs,the biodegradable hollow polymer nanoparticles with high drug load rate and sustainable release ability,have good prospect to treat the bone defect in future clinical practice. | Lu Wang Shuwei Liu Chunxia Ren Siyuan Xiang Daowei Li Xinqing Hao Shilei Ni Yixin Chen Kai Zhang Hongchen Sun | 2021 | International Journal of Oral Science2021，13，3： | 0 |
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