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| 1 | Amplification of the miR-181c/d cluster is inversely correlated with PDCD4 expression in gastric cancer显示文摘miR-181c/d is dysregulated in gastric cancer(GC).We investigated the amplification and expression of miR-181c/d and its predicted target genes in GC.Amplification of miR-181c/d was quantified by genomic real-time PCR in GC and adjacent normal tissues,as well as the levels of mature miR-181c/d was performed by real-time PCR in the same tissues.The potential target genes of miR-181c/d were predicted using bioinformatics software.Expression of one potential target gene,PDCD4,was measured by semiquantitative RT-PCR,real-time PCR,and immunohistochemistry.Next,the relationship between miR181c/d expression and PDCD4 expression was analyzed.Results indicated that the amplification and expression of miR-181c/d were significantly higher in GC than in adjacent normal tissues(primary miR-181c/d,P\0.001;miR-181c,P=0.0344;miR-181d,P=0.0153),and there was a strong correlation between mature miR-181c/d and primary miR-181c/d.Thirty-two target genes were predicted,including PDCD4 which is a known tumor suppressor gene.Expression of PDCD4 was significantly down-regulated in GC as compared to adjacent normal tissues and was inversely correlated with miR-181c/d expression in GC(miR-181c and PDCD4:R=-0.496,P=0.008;miR-181d and PDCD4:R=-0.454,P=0.003).Therefore,miR-181c/d may play a pivotal role in the pathogenesis of GC by downregulating PDCD4 expression. | Yuanming Pan Rui Xing Juan An Jiantao Cui Wenmei Li Mingzhou Guo Youyong Lu | 2014 | Chinese Science Bulletin2014，59，19： | 6 |
| 2 | Polarization-dependent difference of the power spectra from two-dimensional random media with different shapes显示文摘Polarization-dependent difference of the power spectra from a set of two-dimensional (2D) passive random media is investigated by simultaneously solving Maxwell’s equations for both transverse magnetic (TM) and transverse electric (TE) fields. The random media have the same random constitution but different shapes. Results show that both two polarized states are morphology dependent, and the variety of the shapes has more influence on the selection of TM polarized modes than that of TE polarized modes. Such polarization-dependent difference of morphology property presents a new modeselecting technique for random lasers. | LIU Hai LIU JinSong LU JianTao WANG KeJia | 2009 | Chinese Science Bulletin2009，54，18： | 3 |
| 3 | Intrinsic component filtering for fault diagnosis of rotating machinery显示文摘Fault diagnosis of rotating machinery has always drawn wide attention.In this paper,Intrinsic Component Filtering(ICF),which achieves population sparsity and lifetime consistency using two constraints:l1=2 norm of column features and l3=2-norm of row features,is proposed for the machinery fault diagnosis.ICF can be used as a feature learning algorithm,and the learned features can be fed into the classification to achieve the automatic fault classification.ICF can also be used as a filter training method to extract and separate weak fault components from the noise signals without any prior experience.Simulated and experimental signals of bearing fault are used to validate the performance of ICF.The results confirm that ICF performs superior in three fault diagnosis fields including intelligent fault diagnosis,weak signature detection and compound fault separation. | Zongzhen ZHANG Shunming LI Jiantao LU Yu XIN Huijie MA | 2021 | Chinese Journal of Aeronautics2021，34，1： | 3 |
| 4 | A Novel Electric Dual Motor Transmission for Heavy Commercial Vehicles显示文摘As a vital vehicle part,the powertrain system is undergoing a fast transition towards electrification.The new integrated electric drive system has been widely used,especially for passenger cars.In this work,a novel electric dual motor transmission is proposed for heavy commercial vehicles.The transmission scheme is firstly introduced,which can achieve 9 different operating modes including 5 single motor modes and 4 dual motor modes.Then,the mode shift map with minimum energy consumption is designed based on the motor efficiency map and the proposed energy management strategy.The driving power is appropriately distributed between the two motors in dual motor modes under the condition of minimum power consumption.In addition,a coordinated control strategy is developed for mode shift control without power interruption.The results show that the electric dual motor transmission has advantages in power consumption and power shift ability compared with the conventional single motor automated manual transmission. | Xiangyang Xu Jiajia Liang Qingjun Hao Peng Dong Shuhan Wang Wei Guo Yanfang Liu Zhonghua Lu Jiantao Geng Bin Yan | 2021 | Automotive Innovation2021，4，1： | 2 |
| 5 | Coronavirus disease 2019 epidemic prediction in Shanghai under the “dynamic zero-COVID policy”using time-dependent SEAIQR model显示文摘It’s urgently needed to assess the COVID-19 epidemic under the“dynamic zero-COVID policy”in China,which provides a scientific basis for evaluating the effectiveness of this strategy in COVID-19 control.Here,we developed a time-dependent susceptible-exposed-asymptomatic-infected-quarantined-remov ed(SEAIQR)model with stage-specific interventions based on recent Shanghai epidemic data,considering a large number of asymptomatic infectious,the changing parameters,and control procedures.The data collected from March 1st,2022 to April 15th,2022 were used to fit the model,and the data of subsequent 7 days and 14 days were used to evaluate the model performance of forecasting.We then calculated the effective regeneration number(Rt)and analyzed the sensitivity of different measures scenarios.Asymptomatic infectious accounts for the vast majority of the outbreaks in Shanghai,and Pudong is the district with the most positive cases.The peak of newly confirmed cases and newly asymptomatic infectious predicted by the SEAIQR model would appear on April 13th,2022,with 1963 and 28,502 cases,respectively,and zero community transmission may be achieved in early to mid-May.The prediction errors for newly confirmed cases were considered to be reasonable,and newly asymptomatic infectious were considered to be good between April 16th to 22nd and reasonable between April 16th to 29th.The final ranges of cumulative confirmed cases and cumulative asymptomatic infectious predicted in this round of the epidemic were 26,477~47,749 and 402,254~730,176,respectively.At the beginning of the outbreak,Rt was 6.69.Since the implementation of comprehensive control,Rt showed a gradual downward trend,dropping to below 1.0 on April 15th,2022.With the early implementation of control measures and the improvement of quarantine rate,recovery rate,and immunity threshold,the peak number of infections will continue to decrease,whereas the earlier the control is implemented,the earlier the turning point of the epidemic will arrive.The proposed time-dependent SEAIQR dynamic model fits and forecasts the epidemic well,which can provide a reference for decision making of the“dynamic zero-COVID policy”. | Yifei Ma Shujun Xu Qi An Mengxia Qin Sitian Li Kangkang Lu Jiantao Li Lijian Lei Lu He Hongmei Yu Jun Xie | 2022 | Journal of Biosafety and Biosecurity2022，4，2： | 1 |
| 6 | Lightwave localization in two- dimensional anisotropic random media 显示文摘 | Lu Jiantao Liu Jinsong Liu Hai | 2009 | Journal of Modern Op- tics2009，56，9： | 1 |
| 7 | MiR‐23a in amplified 19p13.13 loci targets metallothionein 2A and promotes growth in gastric cancer cells显示文摘 | Juan An Yuanming Pan Zhi Yan Wenmei Li Jiantao Cui Jiao Yuan Liqing Tian Rui Xing Youyong Lu | 2013 | J Cell Biochem2013，，9： | 1 |
| 8 | Performance analysis and comprehensive index optimization of a new configuration of Stewart six-component force sensor显示文摘 | Hou Yulei Yao Jiantao Lu Ling | 2009 | Mechanism and Machine Theory2009，44，2： | 1 |
| 9 | Excitation Functions for Reactions Induced by Deuteron in Iron | Zhao, Wenrong Lu, Hanlin Yu, Weixiang Cheng, Jiantao | 1995 | Chinese journal of nuclear physics1995，，2： | 0 |
| 10 | Heat transfer characterization and improvement in an external catalyst cooler fluidized bed显示文摘Gas-solid fluidized beds have been widely used in heat transfer processes,and so there have been many studies focused on increasing heat transfer in such units.In the present work,a pilot scale cold mode experimental rig was constructed to assess the effects of hydrodynamics on bed-to-wall heat transfer and to investigate various means of enhancing heat transfer in a dense gas-solid fluidized bed with external solid circulation.The experimental results show that heat transfer in the dense region played a dominant role in total bed-to-wall heat transfer,accounting for more than 88%of the total heat transfer load.Heat transfer could be lowered as a result of solids bypass that occurred because of external solids circulation,but this effect was weakened by the radial mixing of particles.The heat transfer characteristics identified in this study indicate that a specially designed baffle can be used to enhance bed-to-wall heat transfer.After installing such baffles in the fluidized bed test structure,a 70%increase in the total heat transfer coefficient was obtained. | Jiantao Li Xiuying Yao Lu Liu Xudong Zhong Chunxi Lu | 2021 | Particuology2021，19，3： | 0 |
| 11 | Robust and Tumor-Environment-Activated DNA Cross-Linker Driving Nanoparticle Accumulation for Enhanced Therapeutics显示文摘Agglomeration of therapeutic nanoparticles in response to tumor microenvironments is a promising approach to enhance drug accumulation and improve therapeutic efficacy.Cytosine-rich DNA sequences show potential as ideal cross-linkers to drive nanoparticle agglomeration because they can sensitively respond to weak acidity and form interchain folding.However,the in vivo application of DNA is generally limited by its poor biostability;as a consequence,modifications with unprotected DNA cross-linkers can enhance the accumulation of nanoparticles twofold at the tumor site.Facing this challenge,we have designed and developed a protection and tumor-environment activation strategy to enable the in vivo application of a DNA cross-linker.Specifically,reactive oxygen species(ROS)-responsive polyethylene glycol(PEG)was modified on the nanoparticle surface together with the DNA crosslinker,which protects DNA from degradation during the blood circulation;meanwhile,when arriving at the tumor site,the nanoparticles shed the PEG shell as a response to ROS to uncover and activate the DNA cross-linkers.Using this strategy,a sevenfold enhancement in tumor accumulation was achieved owing to both superior pH sensitivity and improved stability of DNA cross-linkers.Finally,significantly improved therapeutic efficacy in in vivo anticancer treatment was realized by using this agglomeration strategy driven by protected and stimuli-activated DNA cross-linkers. | Zhicong Chao Hongwei Lu Fan Xiao Chen Shao Zixiang Wei Jiantao Yu Xindan Zhang Li Lin Leilei Tian | 2020 | CCS Chemistry2020，2，5： | 0 |
| 12 | Structural characteristics of the SARS-CoV-2 Omicron lineages BA.1 and BA.2 virions显示文摘Dear Editor,Variants of concern(VOCs)of SARS-CoV-2 have increased transmissibility,virulence,and resistance.The emergence of new VOCs continues to pose great challenges to public health.The detailed structures of the intact Omicron viruses remain unveiled.In this study,we report the architecture of both Omicron BA.1 and BA.2 lineages using cryo-electron tomography(cryo-ET).The subtomogram averaging of viral spikes,in both pre-fusion and postfusion conformations are also investigated. | Xiaoyu Ma Yanqun Wang Yuanzhu Gao Yiliang Wang An Yan Jiantao Chen Lu Zhang Peiyi Wang Jincun Zhao Zheng Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 13 | Structured sparsity assisted online convolution sparse coding and its application on weak signature detection显示文摘Due to the strong background noise and the acquisition system noise,the useful characteristics are often difficult to be detected.To solve this problem,sparse coding captures a concise representation of the high-level features in the signal using the underlying structure of the signal.Recently,an Online Convolutional Sparse Coding(OCSC)denoising algorithm has been proposed.However,it does not consider the structural characteristics of the signal,the sparsity of each iteration is not enough.Therefore,a threshold shrinkage algorithm considering neighborhood sparsity is proposed,and a training strategy from loose to tight is developed to further improve the denoising performance of the algorithm,called Variable Threshold Neighborhood Online Convolution Sparse Coding(VTNOCSC).By embedding the structural sparse threshold shrinkage operator into the process of solving the sparse coefficient and gradually approaching the optimal noise separation point in the training,the signal denoising performance of the algorithm is greatly improved.VTNOCSC is used to process the actual bearing fault signal,the noise interference is successfully reduced and the interest features are more evident.Compared with other existing methods,VTNOCSC has better denoising performance. | Huijie MA Shunming LI Jiantao LU Zongzhen ZHANG Siqi GONG | 2022 | Chinese Journal of Aeronautics2022，35，1： | 0 |
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