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| 1 | Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages显示文摘The nucleotide-binding domain,leucine-rich-repeat containing family,pyrin domain-containing 3(NLRP3)inflammasome is essential in inflammation and inflammatory disorders.Phosphorylation at various sites on NLRP3 differentially regulates inflammasome activation.The Ser725 phosphorylation site on NLRP3 is depicted in multiple inflammasome activation scenarios,but the importance and regulation of this site has not been clarified.The present study revealed that the phosphorylation of Ser725 was an essential step for the priming of the NLRP3 inflammasome in macrophages.We also showed that Ser725 was directly phosphorylated by misshapen(Msn)/NIK-related kinase 1(MINK1),depending on the direct interaction between MINK1 and the NLRP3 LRR domain.MINK1 deficiency reduced NLRP3 activation and suppressed inflammatory responses in mouse models of acute sepsis and peritonitis.Reactive oxygen species(ROS)upregulated the kinase activity of MINK1 and subsequently promoted inflammasome priming via NLRP3 Ser725 phosphorylation.Eliminating ROS suppressed NLRP3 activation and reduced sepsis and peritonitis symptoms in a MINK1-dependent manner.Altogether,our study reveals a direct regulation of the NLRP3 inflammasome by Msn family kinase MINK1 and suggests that modulation of MINK1 activity is a potential intervention strategy for inflammasomerelated diseases. | Kaixiang Zhu Xuexiao Jin Zhexu Chi Sheng Chen Songquan Wu Richard D.Sloan Xuai Lin Dante Neculai Di Wang Hu Hu Linrong Lu | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 2 | Atomic force microscopy in cell biology显示文摘The history, characteristic, operation modes and coupling techniques of atomic force microscopy (AFM) are introduced. Then the application in cell biology is re- viewed in four aspects: cell immobilization methods, cell im- aging, force spectrum study and cell manipulation. And the prospect of AFM application in cell biology is discussed. | LU Zhexue ZHANG Zhiling PANG Daiwen | 2005 | Chinese Science Bulletin2005，50，14： | 2 |
| 3 | Direct electrochemistry and electrocatalysis of hemeproteins entrapped in agarose hydrogel films显示文摘 | LIU Huihong TIAN Zhiquan LU Zhexue | 2004 | Biosens Bioelectron2004，20，2： | 1 |
| 4 | Study on biological effect of La-3+ on Escherichia coli by atomic force microscopy显示文摘 | Lio Peng Liu Yi Lu Zhexue | 2004 | Journal of Inorganic Biochemistry2004，98，1： | 1 |
| 5 | Study on biological effect of La^3 + on Escherichia coli by atomic force microscopy 显示文摘 | Liu Peng Liu Yia Lu Zhexue | 2004 | Journal of Inorganic Biochemistry2004，98，： | 1 |
| 6 | Direct e- lectrochemistry and electroeatalysis of heine proteins en trapped in agarose hydrogel films 显示文摘 | LIU Huihong TIAN Zhiquan LU Zhexue | 2004 | Biosens Bioelectron2004，20，2： | 1 |
| 7 | Cell damage induced by photoca 显示文摘 | Lu Zhexue | 2003 | Langmuir2003，19，： | 1 |
| 8 | Study on biological effect of La3+ on Escherichia coli by atomic forcemicros- eopy显示文摘 | Liu Peng Liu Yia Lu Zhexue | 2004 | Journal of Inorganic Biochemistry2004，98，： | 1 |
| 9 | 胆酸通过抑制NLRP3炎症小体活化控制炎症及代谢综合征的发生显示文摘免疫系统和代谢系统的相互作用彼此影响着对方生理功能的正常发挥,对于维持机体的代谢平衡和免疫稳态起着重要的调节作用。当二者的相互调控出现失衡或发生异常时,往往会导致机体相关病理性事件如代谢综合征、自身免疫性疾病、心血管疾病以及肿瘤等的发生。 | Chuansheng Guo Shujun Xie Zhexu Chi Jinhua Zhang Yangyang Liu Li Zhang Mingzhu Zheng Xue Zhang Dajing Xia Yuehai Ke Linrong Lu 王迪 | 2017 | 科学新闻2017，19，4： | 0 |
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