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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | On the influence of psychrometric ambient conditions on cooling tower drift deposition 显示文摘 | LUCAS M MARTINEZ P J | 2010 | Heat and Mass Transfer2010，53，： | 1 |
| 3 | Vinyl sulfonate co-polymers for high-temperature filtration control of wa- ter-base muds显示文摘 | Perricone A C Enright D P Lucas J M | 1986 | SPE Drilling Engineering1986，1，5： | 1 |
| 4 | Antioxidant response to NaCI stress in sah-tolerant and sahsensitive cultivars of cotton显示文摘 | Gossett D R Millhollon E P Lucas M C | 1994 | Crop Sci1994，34，： | 1 |
| 5 | Hygrothermal effects of epoxy resin 显示文摘 | Zhou J M Lucas J P | 1999 | Part I:The nature of water in epoxy polymer1999，40，： | 1 |
| 6 | Brain-derived neurotrophic factorand antidepressant drugs have different but coordinated effects on neuro-nal turnover,proliferation,and survival in the adult dentate gyrus显示文摘 | Sairanen M Lucas G Ernfors P | 2005 | JNeurosci2005，25，5： | 1 |
| 7 | The influence of chemical composition on the pour point depressant proper- ties of methacrylate copolymers used as additives for lubri- cating oils 显示文摘 | Florea M Catrinoiu D Luca P | 1999 | Lubrication Science1999，31，12： | 1 |
| 8 | Prevention of nosocomial infections in neonatal intensive care units 显示文摘 | Manzoni P De Luca D Stronati M | 2013 | AmJPerinatol2013，30，2： | 1 |
| 9 | Effects of trifluoromethyl ketones and related compounds on the EAG and behavioural responses to pheromones in male moths 显示文摘 | Renou M Lucas P Malo E | 1997 | Chem Senses1997，22，4： | 1 |
| 10 | Abatement costs of post-Kyoto climate regimes显示文摘 | Lucas P van Vuuren D | 2005 | Energy Policy2005，33，： | 1 |
| 11 | Zeolite as efficient catalysts for key transformations in carbohydrate chemistry 显示文摘 | Xavier Nuno M Lucas Susana D Rauter Amelia P | 2009 | Journal of Molecular Catalysis A: Chemical2009，305，12： | 1 |
| 12 | Selective and integrated rehabilitation programs for disturbances of visual/spatial attention and executive function after brain damage: a neuropsychological evidence-based review 显示文摘 | Zoccolotti P Caatagallo & De Luca M | 2011 | Ear J Phys Rehabil Med2011，47，1： | 1 |
| 13 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 14 | Comparative experimental drift study between a dry and adiabatic fluid cooler and a cooling tower显示文摘 | Lucas M Martinez P J Viedma A | 2008 | International Journal of Refrigeration2008，31，7： | 1 |
| 15 | Effective of a nonselec- tive ETA/B and a selective ETA antagonist in rats with mono - crotaline - induced pulmonary hypertension 显示文摘 | Jasmin JF Lucas M Cernacek P | 2001 | Circulation2001，103，： | 1 |
| 16 | Evolution of the structure of a gas-liquid two-phase flow in a large vertical pipe 显示文摘 | Prasser H M Beyer M Carl H Gregor S Lucas D Pietruske H Schutz P Weiss F P | 2007 | Nuclear Engineering and Design2007，237，： | 1 |
| 17 | BCL10 and MALT1,independent targets of chromosomal translocation in MALT lymphoma,cooperate in a novel NF-κB signaling pathway显示文摘 | Lucas P C Yonezumi M Inohara N | 2001 | The Journal of Biology Chemistry2001，276，19： | 1 |
| 18 | Treatment of esophageal spirocercosis with milbemycin oxime显示文摘 | Kelly P J Fisher M Lucas H | 2008 | Vet Parasitol2008，156，34： | 1 |
| 19 | The translocation of 14C- photosynthate from leaves显示文摘 | Lucas E O Milbourn G M Whitford P N | 1976 | Ann Appl Biol1976，83，： | 1 |
| 20 | A headspace solid-phase microextraction gas-chromatographic mass-spectrometric method to quantify hexanal in butter during storage as marker of lipid oxidation显示文摘 | SARA P SILVIA S LUCA M C | 2011 | Food Chemistry2011，127，2： | 1 |
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