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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Outcome in obscure gastrointestinal bleeding after capsule endoscopy显示文摘AIM: To investigate the clinical impact of capsule endoscopy(CE) after an obscure gastrointestinal bleeding(OGIB) episode, focusing on diagnostic work-up, followup and predictive factors of rebleeding. METHODS: Patients who were referred to Hospital del Mar(Barcelona, Spain) between 2007 and 2009 for OGIB who underwent a CE were retrospectively analyzed. Demographic data, current treatment with non-steroid antiinflammtory drugs or anticoagulant drugs, hemoglobin levels, transfusion requirements, previous diagnostic tests for the bleeding episode, as well as CE findings(significant or non-significant), work-up and patient out-comes were analyzed from electronic charts. Variables were compared by χ 2 analysis and Student t test. Risk factors of rebleeding were assessed by Log-rank test, Kaplan-Meier curves and Cox regression model. RESULTS: There were 105 patients [45.7% women, median age of 72 years old(interquartile range 56-79)] and a median follow-up of 326 d(interquartile range 123-641) included in this study. The overall diagnostic yield of CE was 58.1%(55.2% and 63.2%, for patients with occult OGIB and overt OGIB, respectively). In 73 patients(69.5%), OGIB was resolved. Multivariate analysis showed that hemoglobin levels lower than 8 g/dL at diagnosis [hazard ratios(HR) = 2.7, 95%CI: 1.9-6.3], patients aged 70 years and above(HR = 2.1, 95%CI: 1.2-6.1) and significant findings in CE(HR = 2.4, 95%CI: 1.1-5.8) were independent predictors of rebleeding. CONCLUSION: One third of the patients presented with rebleeding after CE; risk factors were hemoglobin levels < 8 g/dL, age ≥ 70 years or the presence of significant lesions. | Alex Caas-Ventura Lucia Márque Xavier Bessa Josep Maria DedeuDepartment of Gastroenterology Hospital del Mar Research Institute Pompeu Fabra University Marc Puigvehí Sílvia Delgado-Aros Ines Ana Ibáez Agustin Seoane Luis Barranco Felipe Bory Montserrat Andreu Begoa González-Suárez | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，11： | 4 |
| 3 | Characterization of a deeply buried paleokarst terrain in the Loppa High using core data and multiattribute seismic facies classification显示文摘 | Jhosnella S Lucia D M Mutti M | 2012 | AAPG Bulletin2012，96，10： | 1 |
| 4 | Cross - sensitizations between azo dyes and para- amino compound 显示文摘 | Stefania S Lucia M | 2007 | Sedenari Et A12007，36，4： | 1 |
| 5 | Determination of bisphenol A and bisphenol B residues in canned peeled tomatoes by reversed-phase liquid chromatography显示文摘 | LUCIA G DOMENICO M SERENELLA S | 2008 | J Agric Food Chem2008，56，10： | 1 |
| 6 | Analysis of continuous glucose monitoring data from non-diabetic and diabetic children: A tale of two algorithms 显示文摘 | WEINZIMER S A DE Lucia M C BOLAND E A | 2003 | Diabetes Technology & Therapeutics2003，5，3： | 1 |
| 7 | 2 Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alphastimulated gene 6 显示文摘 | Garcia G E Wisniewski H G Lucia M S | 2006 | Clin Cancer Res2006，12，31： | 1 |
| 8 | Biocon- version of soy isoflavones daidzin and daidzein by Bifidobacterium strains 显示文摘 | Raimondi S Roncaglia L Lucia D M | 2009 | Applied Microbiology and Biotechnology2009，81，5： | 1 |
| 9 | Bioconversion of soy isoflavones daidzin and daidzein by Bifidobacterium strains显示文摘 | RAIMONDI S RONCAGLIA L LUCIA D M | 2009 | Appl Microbiol Biotechnol2009，81，： | 1 |
| 10 | Connective tissue growth factor expression in prediatric myofibroblastic tumors显示文摘 | Kasaragod A B Lucia M S Cabirac G | 2001 | Pediatr Dev Pathol2001，4，1： | 1 |
| 11 | A 3-D finite ele- ment study of the influence of crown implant ratio on stress distribution 显示文摘 | Lucia M S de Verri D Ramos F | 2013 | Brazilian Dental Journal2013，24，： | 1 |
| 12 | In profes- sional road cyclists, low pedaling cadences are less efficient显示文摘 | Lucia A Juan A F S Montilla M | 2004 | Medicine and Science in Sports and Exercise2004，36，6： | 1 |
| 13 | The Pros- tate Cancer Prevention Trial and the future of chemo- prevention显示文摘 | Thompson I M Tangen C M Lucia M S | 2008 | BJU Int2008，101，8： | 1 |
| 14 | an asynchronous parallel metaheuristic for the period vehicle routing problem显示文摘 | Lucia M A Drummond Luiz S Oehi Dalessandro S Vianna | 2001 | Future Generation Computer Systems2001，17，4： | 1 |
| 15 | Effect of monensin on milk production and efficiency of dairy cows fed two diets differing in forage to concentrate ratios显示文摘 | Ramanzin M Lucia B Stefano S | 1997 | Journal of Dairy Science1997，80，： | 1 |
| 16 | Generalized B-splines as a tool in isogeometric analysis显示文摘 | MANNI C PELOSI F LUCIA S M | 2011 | Comput Methods Appl Mech & Eng2011，200，58： | 1 |
| 17 | Effect of skeletonization of internal thoracic artery on vessel wall integrity显示文摘 | Gaudino M Toesca A Lucia S | 1999 | Ann Thorac Surg1999，68，5： | 1 |
| 18 | Transesterication reaction of vegetable ils, using superacid sulfated TiO2-base catalysts显示文摘 | Rusiene M de Almeida Lucia K Noda Norberto S Goncalves | 2008 | Applied Catalysis A: General2008，347，： | 1 |
| 19 | Induction of CD69 antigen on normal CD4+ and CD8+ lymphocyte subsets and its relationship with the phenotype of responding T-cells显示文摘 | Rutella S Rumi C Lucia M B | 1999 | Cytometry1999，38，： | 1 |
| 20 | The prostate cancer preven tion trial and the future of chemoprevention显示文摘 | Thompson I M Tang C M Lucia M S | 2008 | BJU Int2008，10，1： | 1 |
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