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| 1 | Contribution of the IL-17/IL-23 axis to the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel diseases(IBDs) are chronic disorders of modern society, requiring management strategies aimed at prolonging an active life and establishing the exact etiology and pathogenesis.These idiopathic diseases have environmental, genetic,immunologic, inflammatory, and oxidative stress components. On the one hand, recent advances have shown that abnormal immune reactions against the microorganisms of the intestinal flora are responsible for the inflammation in genetically susceptible individuals. On the other hand, in addition to T helper cell-type(Th) 1 and Th2 immune responses,other subsets of T cells, namely regulatory T cells and Th17 maintained by IL-23 are likely to develop IBD. IL-23 acts on innate immune system members and also facilitates the expansion and maintenance of Th17 cells. The IL-17/IL-23 axis is relevant in IBD pathogenesis both in human and experimental studies. Novel biomarkers of IBD could be calprotectin,microRNAs, and serum proinflammatory cytokines.An efficient strategy for IBD therapy is represented by the combination of IL-17 A and IL-17 F in acute IL-17 A knockout TNBS-induced colitis, and also definite decrease of the inflammatory process in IL-17 F knockout, DSS-induced colitis have been observed.Studying the correlation between innate and adaptive immune systems, we hope to obtain a focused reviewin order to facilitate future approaches aimed at elucidating the immunological mechanisms that control gut inflammation. | Cristina-Sorina Cǎanǎ Ioana Berindan Neagoe Vasile Cozma Cristian Magdas Flaviu Tǎbǎan Dan Lucian Dumitrasu | 2015 | World Journal of Gastroenterology2015，21，19： | 37 |
| 2 | Posterolateral Transfibular Approach to Tibial Plateau Fractures: Technique, Results, and Rationale显示文摘 | Lucian B Solomon Aaron W Stevenson Robert P V Baird Anthony P Pohl | 2010 | Journal of Orthopaedic Trauma2010，，8： | 2 |
| 3 | Nearest interval, triangular and trapezoidal approximation of a fuzzy number preserving ambiguity显示文摘 | Adrian I B Lucian C | 2012 | International Journal of Approximate Reasoning2012，53，： | 1 |
| 4 | P-glycoprotein is strongly expression in the luminal membranes of the endothelium of blood vessels in the brain显示文摘 | EDITH B MICHEL D LUCIAN G | 1997 | Biochem J1997，326，： | 1 |
| 5 | A digital controlled PV-inverter with grid impedance estimation for ENS detection显示文摘 | LUCIAN A REMUS T FREDE B | 2005 | IEEE Transactions on Power Electronics2005，20，6： | 1 |
| 6 | A multi-scale approach to improve reservoir charac- terization and forecasting: the Albacora Field (deep water offshore Brazil) study显示文摘 | Luciane B C Alberto cla S B Cristiano L S | 2001 | Petroleum Geosci- ence2001，7，5： | 1 |
| 7 | High performance current controller for selective harmonic compensation in active power filters显示文摘 | Cristian L Lucian A Ion B | 2007 | IEEE Transactions on Power Electronics2007，22，5： | 1 |
| 8 | Enhanced xylitol production by precultivation of Candida guilliermondii cells in sugarcane bagasse hemicellulosic hydrolysates显示文摘 | Rita C L B Rodrigues Luciane Sene Gilvane S Matos | 2006 | Current Microbiology2006，53，： | 1 |
| 9 | Variable speed electric generators and their control:an emerging technology显示文摘 | Ion B Lucian T Ioan S | 2002 | Journal of Electrical Engineering2002，，3： | 1 |
| 10 | Enhanced xylitol production by precultivation of Candida guilliermondii cells in sugarcane bagasse hemicellulosic hydrolysate显示文摘 | Rita C L B R Luciane S Gilvane S M | 2006 | Curr Microbiol2006，53，1： | 1 |
| 11 | Variable Speed Electric Generators and Their Control: an Emerging Technology 显示文摘 | ION B LUCIAN T IOAN S | 2002 | Journal of Electrical Engineering2002，24，3： | 1 |
| 12 | The ABC transporter AtPDR8 is a cadmium extrusion pump conferring heavy metal resistance 显示文摘 | Kim D Y Lucian B Masayoshi M | 2007 | The Plant Journal2007，50，： | 1 |
| 13 | Experience replay for real-time reinforcement learning control显示文摘 | ADAM S LUCIAN B BABUKA R | 2012 | IEEE Transactions on Systems Man and Cybernetics Part C:Applications and Reviews2012，42，2： | 1 |
| 14 | The antibacterial properties of sulfur containing flavonoids 显示文摘 | Lucian G B Mircea O A Lucian M B | 2014 | Bioorganic & Medicinal Chemistry Letters2014，24，： | 1 |
| 15 | Correlation of approximate entropy, bispectral index, and spectral edge frequency 95 (SEF95) with clinical signs of “Anesthesia Depth”during coadministration of propofol and remifentanil 显示文摘 | Jorgen B Thomas WB Lucian R | 2003 | Anesthesiology2003，98，： | 1 |
| 16 | A comprehensive survey of multiagent reinforcement learning显示文摘 | Lucian B Robert B Bart D S | 2008 | IEEE Transactions on Systems Man and Cybernetics-Part C:Applications and Reviews2008，38，2： | 1 |
| 17 | The uneasy case for the priority of secured claims in bankruptcy显示文摘 | Lucian A B and Jesse M F | 1996 | Yale Law Journal1996，105，： | 1 |
| 18 | Variable speed electric generators and their control:an emerging technology显示文摘 | ION B LUCIAN T IOAN S | | 0，，03： | 1 |
| 19 | A comprehensive survey of Muhi-Agent reinforcement learning 显示文摘 | LUCIAN B ROBERT B BART D S | 2008 | IEEE Transactions on Sys- tem Man and Cybernetics--Part C: Application and Review2008，38，2： | 1 |
| 20 | A digital controlled PV- inverter with grid impedance estimation for ENS detection显示文摘 | LUCIAN A REMUS T FREDE B | 2005 | IEEE Trans on Power Electronics2005，20，6： | 1 |
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