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| 1 | Peripheral blood lymphocytes DNA in patients with chronic liver diseases显示文摘BACKGROUND Viral replication in blood cells with nucleuses may lead to the damage of lymphocytes genetic apparatus and the beginning of immunopathological reactions.AIM Of this investigation is to reveal the damage to peripheral blood lymphocytes (PBL)DNA in the patients with chronic liver diseases.MATERIALS AND METHODS Sixteen-ninepatients with chronic liver diseases (37 patients with chronic viral hepatitis, 2 patients with liver cirrhosis of mixed etiology (alcohol + virus G),30 women with primary biliary cirrhosis-PBC)were examined. The condition of DNA structure of PBL-was measured by the fluorescenceanalysis of DNA unwinding (FADU) technique with modification. Changes of fluorescence (in %) reflected the DNA distractions degree (thepresence of DNA single-stranded breaks and alkalinelabile sights).RESULTS AND CONCLUSION . The quantity of DNA single-stranded breaks and alkalinelabile sightsin DNA in all patients with chronic viral hepatitis .didnt differ from the control group,excluding the patients with chronic hepatitis (CH) C + G. Patients with HGV and TTV monoinfection had demonstrated the increase of the DNA single-stranded breaks PBL quantity.This fact may be connected with hypothesisabout the viruses replication in white blood cells discussed in the literature. Tendency to increase quantity of DNA PBL damages in the patients with primary biliary cirrhosis (PBC) accordingly to the alkaline phosphatase activity increase was revealed. Significant decrease of the DNA single-stranded breaks and alkalinelabile sights in the PBC patients that were treated with prednison was demonstrated. Probably, the tendency to increase the quantity of DNA singlestranded breaks and alkalinelabile sights in lymphocytes of the PBC patients was depended on the surplus of the blood bile acid content. | Vasiliy I Reshetnyak Tatyana I Sharafanova Ludmila U Ilchenko Elena V Golovanova Gennadiy G Poroshenko | 2001 | World Journal of Gastroenterology2001，7，2： | 6 |
| 2 | 从附睾到卵子:CRISP蛋白在哺乳动物受精过程中的作用显示文摘哺乳动物的受精过程涉及精卵结合的很多步骤,是一个非常复杂的过程,其分了机制亟待阐明。此篇综述主要论述了CRISP(富含半胱氨酸的分泌蛋白)作为模型分子在哺乳动物受精过程中的价值。大量的体外实验和基因敲出模型研究显示,附睾内的CRISP1以两种不同的亲和力结合于精子表面,参与精子获能、精子-透明带结合、精卵融合的调控。这些研究成果可以延伸至人类。我们住研究中发现,人类具有与啮齿类同源的CRISP(hCRISP1),同样参与受精过样。CRISP家族的其他成员(睾丸内CRISP2、附挈内CRISP3—4、射精时的CRISP3)也参与了精卵结合的过程,提示同源分子间的相互协同有助于受精的成功。另外,我们的研究显示,CRISP蛋白伴随精子穿越男性及女性生殖管道的全过程。我们推测CRISP不仅参与了受精过程,而且可能成为不育和避孕研究的新靶点。 | Vanina G Da Ros Mariana Weigel Munoz Maria A Battistone Nicolas G Brukman Guillermo Carvajal Ludmila Curci Matlas D Gomez-Elias Debora J Cohen Patricia S Cuasnicu | 2015 | Asian Journal of Andrology2015，17，5： | 5 |
| 3 | Molecular mass characteristics of polyethylene produced with supported vanadium-magnesium catalysts显示文摘 | Ludmila G Echevskaya Mikhail A Matsko Tatiana B Mikenas | 2006 | Maeromol Chem Phys2006，55，2： | 1 |
| 4 | Mass transfer enhancement in the Membrane Aromatic Recovery System (MARS):experimental results and comparison with theory显示文摘 | Frederico C Ferreira Ludmila G Peeva Andrew G Livingston | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 5 | Mass transfer enhancement in the Membrane Aromatic Recovery System(MARS):theoretical analysis显示文摘 | Frederico C Ferreira Ludmila G Peeva Andrew G Livingston | 2005 | Chemical Engineering Science2005，60，： | 1 |
| 6 | Phenol degradation by immobilized cold-adapted yeast strains of Cryptococcus terreus and Rhodotorula creatinivor显示文摘 | IRNA K SVETLANA G LUDMILA S | 2006 | Extremophiles2006，，10： | 1 |
| 7 | The use of constructed wetlands for the treatment of run-off and Drainage Waters:the UKand UKRAINE experience显示文摘 | Vyacheslav G M Michael A Z Ludmila I Y | 1996 | Water Science and Technology1996，33，425： | 1 |
| 8 | The effects of ethylene methyl Jasmonate and 1-MCP on abscission of cherry tomatoes from the bunch and expression of endo-1,4-β-glucanases显示文摘 | DELIA BM LUDMILA G ORIT D | 2004 | Plant Science2004，167，3： | 1 |
| 9 | The use of constructed wetlands for the treatment of run-off and drainage waters:the UK and UKRAINE experience显示文摘 | VYACHESLAV G M MICHAEL A Z LUDMILA I Y | 1996 | Water Science and Technology1996，33，425： | 1 |
| 10 | Small interfering RNA inhibits Hepatitis B virus replication in mice显示文摘 | Hilla G Mali K G Ludmila R | 2003 | Molecular Therapy2003，8，： | 1 |
| 11 | Clinical Performance of PET/CT in Evaluation of Cancer:Additional Value for Diagnostic Imaging and Patient Management显示文摘 | Rachel B S Nikolai Y Ludmila G | | 0，，08： | 1 |
| 12 | Molecular danalyses of the15q and 18q SMAD genes in pancreatic cancer显示文摘 | Tord J Ludmila G Sigmund D | 1999 | Genes Chromosomes Cancer1999，24，： | 1 |
| 13 | Spectroscopic characterization of humic acid fractions isolated from soil u-sing different extraction procedures显示文摘 | LUDMILA TIMOFEEVNA SHIRSHOVA GHABBOUR E A DAVIES G | 2006 | Geoderma2006，133，： | 1 |
| 14 | Effect of ex- treme an aerobic exercise event on autonomic nervous system ac- tivity in professional runners 显示文摘 | Ludmila L Raczak G Szwoch M | 2007 | Medycyna Sport owa2007，4，6： | 1 |
| 15 | Spectrophotometric,electron spin resonance,polarographic,and chemiluminescent study of biologically active chelators:1-allyl-2-methyl-3-hydroxy-4-pyridinone,lipoic and dihydrolipoic acids显示文摘 | Afanas' ev Ilya I Korkina Ludmila G Kozlov Andrey V | 1996 | Phys Chem Biol & Med1996，3，1： | 1 |
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