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		题名	作者	年代	出处	被引量
	1	Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.	Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet	2022	Bone Research2022，10，1：	1
	2	Apical leakage of four endodontic sealers显示文摘	Ludovic P Imad A David P	2003	J Endod2003，29，2：	1
	3	Neuromuscular fatigue during long-duration cycling exercise显示文摘	ROMUALD Lepers NICOLA A Maffiuletti LUDOVIC Rochette	2002	J Appl Physiol2002，92，：	1
	4	Measuring project complexity using the Analytic Hierarchy Process 显示文摘	LUDOVIC A	2011	International Journal of ProjectManagement2011，29，6：	1
	5	Microscopic modeling of the relaxation phenomenon using a macroscopic lane-changing model 显示文摘	Jorge A Laval Ludovic Leclercq	2008	Transportation Research PartB2008，42，1：	1
	6	Jean Farncois a D-dimer can predict survival in patients with chronic atrial fibrillation显示文摘	Mahe Isablelle A Drouet Ludovic B Simoneau Guy A	2004	Blood Coagulation & Fibrinolysis2004，15，5：	1
	7	Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells显示文摘	Rashid S Tamir Corbineau Sebastien Hannan Nick Marciniak Stefan J Miranda Elena Alexander Graeme Huang-Doran Isabel Griffin Julian Ahrlund-Richter Lars Skepper Jeremy Semple Robert Weber Anne Lomas David A Vallier Ludovic	2010	Journal of Clinical Investigation2010，，9：	1
	8	Sperm Size and Number Variation in the Red Flour Beetle显示文摘	Ludovic A Eric H Mathew J G G	2001	Zoological Journal of the Linnean Society2001，133，：	1
	9	Using a Delphi process and the Analytic Hierarchy Process (AHP) to evaluate the complexity of projects 显示文摘	LUDOVIC A FRANCK M JEAN C B	2011	Volume 38 Issue 5 May 20112011，，：	1
	10	Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis显示文摘	Ludovic A Adeline H Fran Oise P	2007	J Exp Med2007，204，5：	1
	11	A fuzzy-possibilistic scheme of study for objects with indeterminate boundaries: application to French Polynesian reef scapes显示文摘	SERGE A LUDOVIC R YANNICK C	2000	IEEE Transaction on Geoscience and Remote Sensing2000，38，1：	1
	12	Fourier analysis of multi-temporal AVHRR data applied to a land cover classification显示文摘	LUDOVIC ANDRES WILLIAM A S DAVID SKOLE	1994	International Journal of Remote Sensing1994，15，：	1
	13	A mechanism to describe the formation and propagation of stop-and-go waves in congested freeway traffic显示文摘	Jorge A L Ludovic L	2010	Phil Trans R Soc A2010，368，：	1
	14	Innovative method for determination of19polycyclic aromatic hydrocarbons in food and oil samples using gas chromatography coupled to tandem mass spectrometry based on an isotope dilution approach显示文摘	Veyrand B Brosseaud A Ludovic S	2007	Journal of chromatography A2007，1149，2：	1
	15	A fuzzy-possibilistie scheme of study for obiects with indeterminate boundaries: application to French Polynesian reef scapes 显示文摘	SERGE A LUDOVIC R YANNICK C	2000	IEEE Transaction on Geoscience and Remote Sensing2000，38，1：	1
	16	Blind modulation recognition for MIMO systems 显示文摘	Vincent C Stephane A Koffi Y Ludovic C and Gilles B	2009	Journal of ATM Bucharest2009，，2：	1
	17	Interactionbetween the surface properties of the textilesand the deposition of cationic softener 显示文摘	GAURAV A ANNE P LUDOVIC K	2012	Journalof Surfactants and Detergents2012，15，1：	1
	18	Inflammatory monocytes recruited after skeletal muscle injury switch into antiinfl ammatory macrophages to support myogenesis显示文摘	Ludovic A Adeline H	2007	J Exp Med2007，204，5：	1

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