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| 1 | Osteopontin as potential biomarker and therapeutic target in gastric and liver cancers显示文摘Gastric cancer and liver cancer are among the most common malignancies and the leading causes of death worldwide,due to late detection and high recurrence rates.Today,these cancers have a heavy socioeconomic burden,for which a full understanding of their pathophysiological features is warranted to search for promising biomarkers and therapeutic targets.Osteopontin (OPN) is overexpressed in most patients with gastric and liver cancers.Over the past decade,emerging evidence has revealed a correlation of OPN level and clinicopathological features and prognosis in gastric and liver cancers,indicating its potential as an independent prognostic indicator in such patients.Functional studies have verified the potential of OPN knockdown as a therapeutic approach in vitro and in vivo .Furthermore,OPN mediates multifaceted roles in the interaction between cancer cells and the tumor microenvironment,in which many details need further exploration.OPN signaling results in various functions,including prevention of apoptosis,modulation of angiogenesis,malfunction of tumor-associated macrophages,degradation of extracellular matrix,activation of phosphoinositide 3-kinase-Akt and nuclear factor-κB pathways,which lead to tumor formation and progression,particularly in gastric and liver cancers.This editorial aims to review recent findings on alteration in OPN expression and its clinicopathological associations with tumor progression,its potential as a therapeutic target,and putative mechanisms in gastric and liver cancers.Better understanding of the implications of OPN in tumorigenesis might facilitate development of therapeutic regimens to benefit patients with these deadly malignancies. | Dong-Xing Cao Zhi-Jie Li Xiao-Ou Jiang Yick Liang Lum Ester Khin Nikki P Lee Guo-Hao Wu John M Luk | 2012 | World Journal of Gastroenterology2012，18，30： | 29 |
| 2 | Dickkopfs and Wnt/β-catenin signalling in liver cancer显示文摘Liver cancer is the fifth and seventh most common cause of cancer in men and women,respectively.Wnt/β-catenin signalling has emerged as a critical player in both the development of normal liver as well as an oncogenic driver in hepatocellular carcinoma(HCC).Based on the current understanding,this article summarizes the possible mechanisms for the aberrant activation of this pathway with specific focus on HCC.Furthermore,we will discuss the role of dickkopfs(DKKs)in regulating Wnt/β-catenin signalling,which is poorly understood and understudied.DKKs are a family of secreted proteins that comprise at least four members,namely DKK1-DKK4,which act as inhibitors of Wnt/β-catenin signalling.Nevertheless,not all members antagonize Wnt/β-catenin signalling.Their functional significance in hepatocarcinogenesis remains to be further characterized for which these studies should provide new insights into the regulatory role of DKKs in Wnt/β-catenin signalling in hepatic carcinogenesis.Because of the important oncogenic roles,there are an increasing number of therapeutic molecules targetingβ-catenin and the Wnt/β-catenin pathway for potential therapy of HCC. | Sarwat Fatima Nikki P Lee John M Luk | 2011 | World Journal of Clinical Oncology2011，2，8： | 11 |
| 3 | Hepatic tight junctions:From viral entry to cancer metastasis显示文摘The tight junction (TJ) is a critical cellular component for maintenance of tissue integrity, cellular interactions and cell-cell communications, and physiologically functions as the 'great wall' against external agents and the surrounding hostile environment. During the host-pathogen evolution, viruses somehow found the key to unlock the gate for their entry into cells and to exploit and exhaust the host cells. In the liver, an array of TJ molecules is localized along the bile canaliculi forming the blood-biliary barrier, where they play pivotal roles in paracellular permeability, bile secretion, and cell polarity. In pathology, certain hepatic TJ molecules mediate virus entry causing hepatitis infection; deregulation and functional abnormality of the TJ have also been implicated in triggering liver cancer development and metastasis. All these findings shed new insights on the understanding of hepatic TJs in the development of liver disease and provide new clues for potential intervention. | Nikki P Lee John M Luk | 2010 | World Journal of Gastroenterology2010，16，3： | 4 |
| 4 | Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?显示文摘Growing prevalence of diabetes(type 2 as well as type 1) and its related morbidity due to vascular complications creates a large burden on medical care worldwide. Understanding the molecular pathogenesis of chronic micro-, macro- and avascular complications mediated by hyperglycemia is of crucial importance since novel therapeutic targets can be identified and tested. Thiamine(vitamin B1) is an essential cofactor of several enzymes involved in carbohydrate metabolism and published data suggest that thiamine metabolism in diabetes is deficient. This review aims to point out the physiological role of thiamine in metabolism of glucose and amino acids, to present overview of thiamine metabolism and to describe the consequences of thiamine deficiency(either clinically manifest or latent). Furthermore, we want to explain why thiamine demands are increased in diabetes and to summarise data indicating thiamine mishandling in diabetics(by review of the studies mapping the prevalence and the degree ofthiamine deficiency in diabetics). Finally, we would like to summarise the evidence for the beneficial effect of thiamine supplementation in progression of hyperglycemia-related pathology and, therefore, to justify its importance in determining the harmful impact of hyperglycemia in diabetes. Based on the data presented it could be concluded that although experimental studies mostly resulted in beneficial effects, clinical studies of appropriate size and duration focusing on the effect of thiamine supplementation/therapy on hard endpoints are missing at present. Moreover, it is not currently clear which mechanisms contribute to the deficient action of thiamine in diabetes most. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given. | Luká? Pácal Katarína Kuricová Katerina Kaňková | 2014 | World Journal of Diabetes2014，5，3： | 3 |
| 5 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 6 | Effect of grain size on the high cycle fatigue behavior of polycrystalline copper显示文摘 | Lukás P Kunz L | 1987 | Materials Science and Engineering1987，85，： | 1 |
| 7 | Effects of symmetric distribution laws on spectral power density in randomized PWM显示文摘 | Drissi K E K Luk P C K Wang Bin | 2003 | IEEE Power Electronics Letters2003，1，2： | 1 |
| 8 | Development of a low cost software package for the design of a brushless DC motor controller显示文摘 | | 1994 | Proceeding from Electrotechnical Conference1994，，1214： | 1 |
| 9 | Gaussian random number generators显示文摘 | Thomas D B Luk W Leong P H W etal | 2007 | ACM Computing Surveys2007，39，4： | 1 |
| 10 | Efficient modelling for a brushless DC motor drive显示文摘 | | 1994 | Proceeding from Industrial Electronics Control and Instrumentation1994，1，59： | 1 |
| 11 | Effects of symmetric distribution laws on spectral power density in randomized PWM 显示文摘 | DRISSI K E K LUK P C K WANG B | 2003 | IEEE Power Electronics Letters2003，1，2： | 1 |
| 12 | A hardware Gaussian noise generator using the Box-Muller method and its error analysis 显示文摘 | Lee Dong-U Villasenor J D Luk W and Leong P H W | 2006 | IEEE Transactions on Computers2006，55，6： | 1 |
| 13 | Input-based and time-based models of international adjustment:Meta-analytic evidence and theoretical extensions显示文摘 | Bhaskar-Shrinivas P Harrison D.A Shaffer M.A Luk D.M | | 0，，02： | 1 |
| 14 | Stakeholder orientation and business perform- ance:The case of service companies in China显示文摘 | Luk C Yau Oliver H M Chow Raymond P M | 2005 | Journal of International Marketing2005，13，13： | 1 |
| 15 | The benefits of 'guanxi': The value of relationship in developing Chinese market显示文摘 | Davies H Leung T K P Luk S T K and Wong Y | 1995 | Industrial Marketing Management1995，24，3： | 1 |
| 16 | Chronic salinity adaptation modulates hepatic heat shock protein and insulinlike growth factor I expression in black sea bream显示文摘 | DEANE E E KELLY S P LUK J C Y | 2002 | Mar Biotechnol2002，4，2： | 1 |
| 17 | Accessory parotid gland tumours:24 years of clinical experience显示文摘 | Luk(s)i(c) I Suton P Rogie M | | 0，，12： | 1 |
| 18 | Epidemiology of hyperuricemia and gout 显示文摘 | LUK A J SIMKIN P A | 2005 | Am J Manag Care2005，11，15： | 1 |
| 19 | A comparison of chinese document indexing strategies and retrieval models 显示文摘 | Luk R W P Kwok K L | 2002 | ACM Transactions on Asian Language Information Processing2002，1，3： | 1 |
| 20 | Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons显示文摘 | Luk KC Ste-Marie L | 2003 | Development2003，130，11： | 1 |
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