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| 1 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Antioxidant efficiency of lycopene on oxidative stress-induced damage in bovine spermatozoa显示文摘Background: Lycopene(LYC) is a natural carotenoid with powerful reactive oxygen species(ROS) scavenging activities. The aim of this study was to investigate if lycopene has the ability to reverse ROS-mediated alterations to the motility, viability and intracellular antioxidant profile of bovine spermatozoa subjected to ferrous ascorbate(Fe AA). Spermatozoa were washed out of fresh bovine semen, suspended in 2.9 % sodium citrate and subjected to LYC treatment(0.25, 0.5, 1 or 2 mmol/L) in the presence or absence of Fe AA(150 μmol/L Fe SO_4 and 750 μmol/L ascorbic acid) during a 6 h in vitro culture. Spermatozoa motion characteristics were assessed using the Sperm Vision?computer-aided sperm analysis(CASA) system. Cell viability was examined with the metabolic activity(MTT) assay,ROS generation was quantified via luminometry and the nitroblue-tetrazolium(NBT) test was applied to quantify the intracellular superoxide formation. Cell lysates were prepared at the end of the in vitro culture to investigate the intracellular activity of superoxide dismutase(SOD), catalase(CAT), glutathione peroxidase(GPx) as well as the concentrations of glutathione(GSH) and malondialdehyde(MDA).Results: FeA A treatment led to a reduced spermatozoa motility(P < 0.001), viability(P < 0.001) and a decline of the antioxidant capacity of spermatozoa(P < 0.001) but increased the ROS generation(P < 0.001), superoxide production(P < 0.001) and lipid peroxidation(P < 0.001). LYC administration resulted in a preservation of the spermatozoa motion parameters(P < 0.001), mitochondrial activity(P < 0.001) and antioxidant characteristics(P < 0.001 with respect to SOD;P < 0.01 in relation to CAT; P < 0.05 as for GPx and GSH) with a concentration range of 1 and 2 mmol/L LYC revealed to be the most effective.Conclusions: Our results suggest that LYC exhibits significant ROS-scavenging and antioxidant properties which may prevent spermatozoa alterations caused by oxidative stress, and preserve the functionality of male reproductive cells. | Eva Tvrdá Anton Kovácik Eva Tusimová Dusan Paál Alica Mackovich Jakhongir Alimov Norbert Lukác | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 3 |
| 3 | Molecular cytogenetic analysis of non-small cell lung carcinoma by spectral karyotyping and comparative genomic hybridization 显示文摘 | Luk C Tsao M- S Bayani J Shepherd F Squire JA | 2001 | Cancer Genetics and Cytogenetics2001，125，： | 1 |
| 4 | Comparing suprapu bic urine aspiration under real-time ultrasound guidance with conventional blind aspiration显示文摘 | Chu R W Wong Y C Luk S H Wong S N | 2002 | Acta Paediatr2002，91，： | 1 |
| 5 | A study of optimal model lag and spatial inputs to artificial neural network for rainfall forecasting显示文摘 | K C Luk J E Ball A sharma | 2000 | Journal of Hydrology2000，227，： | 1 |
| 6 | Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly显示文摘 | Abate C Luk D Gentz R | 1990 | Proc Natl Acad Sci USA1990，87，3： | 1 |
| 7 | Effects of symmetric distribution laws on spectral power density in randomized PWM显示文摘 | Drissi K E K Luk P C K Wang Bin | 2003 | IEEE Power Electronics Letters2003，1，2： | 1 |
| 8 | A study of optimal model lag and spatial inputs to artificial neural net-work for rainfall forecasting显示文摘 | Luk K C Ball J E Sharma A | | 0，，： | 1 |
| 9 | Architectural and Compiler Support for Effective Instruction Prefetching: A Cooperative Approach 显示文摘 | Luk C Mowry T C | 2001 | ACM Trans on Comput Syst2001，19，1： | 1 |
| 10 | Development of a low cost software package for the design of a brushless DC motor controller显示文摘 | | 1994 | Proceeding from Electrotechnical Conference1994，，1214： | 1 |
| 11 | Efficient modelling for a brushless DC motor drive显示文摘 | | 1994 | Proceeding from Industrial Electronics Control and Instrumentation1994，1，59： | 1 |
| 12 | Predicting bone scan findings using sPSA in patients newly diagnosed of prostate cancer:Feasibility in Asian population显示文摘 | Lai M H Luk W H Chan J C | 2011 | Urol Oncol2011，29，3： | 1 |
| 13 | Estrogen receptor alpha CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postm- enopausal women 显示文摘 | LAI B M CHEUN C L LUK K D | 2008 | Osteoporos Int2008，19，4： | 1 |
| 14 | Demonstration of three major species of pseudorabies virus glycoprotein and identification of a disulfide-linked glycoprotein complex显示文摘 | Noé mi Lukàcs Heinz-Jürgen Thiel Thomas C Mettenleiter | 1985 | J Virol1985，53，1： | 1 |
| 15 | Threshold Contrast Ratio and Masking Ability of Porcelain Veneers with High-density Alumina Cores显示文摘 | Chu F C Sham A S Luk H W | 2004 | Int J Prosthodont2004，17，： | 1 |
| 16 | Effects of symmetric distribution laws on spectral power density in randomized PWM 显示文摘 | DRISSI K E K LUK P C K WANG B | 2003 | IEEE Power Electronics Letters2003，1，2： | 1 |
| 17 | Mapping of the structural gene of pseudorabies virus glycoprotein A and identification of two non-glycosylated precursor polypeptides 显示文摘 | Thomas C Mettenleiter Noèmi Lukàcs Hanns-Joachim Rziha | 1985 | J Virol1985，53，1： | 1 |
| 18 | Pin:Building customized program analysis tools with dynamic instrumentation 显示文摘 | Luk C K Cohn R Muth R | 2005 | Association of Computer Machinery Sigplan Notices2005，40，6： | 1 |
| 19 | Prospective audit ofthe use of fresh-frozen plasma,based on Canadian Medi-cal Association trans fusion guidelines显示文摘 | Luk C Eckert KM Barr RM | 2002 | CMAJ2002，166，12： | 1 |
| 20 | Stakeholder orientation and business perform- ance:The case of service companies in China显示文摘 | Luk C Yau Oliver H M Chow Raymond P M | 2005 | Journal of International Marketing2005，13，13： | 1 |
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