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| 1 | Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement显示文摘 | LUTCHMAN G PROMRAT K KLEINER D E | 2006 | Clin Gastroenterol Hepatol2006，4，8： | 1 |
| 2 | Formulation of rate-modulating pellets for the release of ibuprofen : an extrusion- spheronisation process 显示文摘 | LUTCHMAN D DANGOR C M PERUMAL D | 2005 | J Microencapsul2005，22，6： | 1 |
| 3 | Lamivudineand adefovir versus adefovir alone forhbeag-positive chronichepatitis B显示文摘 | GHANY M LUTCHMAN G KLEINER D | 2005 | Hepatology2005，42，41： | 1 |
| 4 | Changes in serum adipokine levels during pioglita- zone treatment for nonalcoholic steatohepatitis: rela- tionship to histological improvement显示文摘 | LUTCHMAN G PROMRAT K KLEINER D E | 2006 | Clin Gastroen- terol Hepatol2006，4，： | 1 |
| 5 | Regulation of CRE -mediated transcription in mouse brain by amphetamine 显示文摘 | Shaw -Lutchman TZ Impey S Storm D | 2003 | Synapse2003，48，： | 1 |
| 6 | Enhancing drug incorporation into tetracycline-loaded chitosan microspheres for periodontal therapy显示文摘 | Govender S Lutchman D Pillay V | 2006 | J Microencapsul2006，23，7： | 1 |
| 7 | Clinical trial : pilot study of metformin for the treatment of non-alcoholic steatohepatitis 显示文摘 | Loomba R Lutchman D Kleiner E | 2008 | Aliment Pharmacol Ther2008，29，2： | 1 |
| 8 | Lamivudine and adefovir versus adefovir alone for HBeAg-positive chronic hepatitis B 显示文摘 | Ghany M Lutchman G Kleiner D | 2005 | Hepatology2005，42，59： | 1 |
| 9 | Clinical trial : pilotstudy of metformin for the treatment of non- alcoholic steatohepatitis 显示文摘 | Loomba R Lutchman G Kleiner D E | 2009 | Aliment Pharmacol Therapeut2009，29，： | 1 |
| 10 | Lamivudineand adefovir versus adefovir alone for HBeAg -positive chronic hepatitis B显示文摘 | Ghany M Lutchman G Kleiner D | 2005 | Hepatology2005，42，41： | 1 |
| 11 | Hepatitis E virus: Western Cape, South Africa显示文摘AIM To conduct a prospective assessment of anti-hepatitis E virus(HEV) Ig G seroprevalence in the Western Cape Province of South Africa in conjunction with evaluating risk factors for exposure.METHODS Consenting participants attending clinics and wards of Groote Schuur, Red Cross Children's Hospital and their affiliated teaching hospitals in Cape Town, South Africa, were sampled. Healthy adults attending blood donor clinics were also recruited. Patients with known liver disease were excluded and all major ethnic/race groups were included to broadly represent local demographics. Relevant demographic data was captured at the time of sampling using an interviewer-administered confidential questionnaire. Human immunodeficiency virus(HIV) status was self-disclosed. HEV Ig G testing was performed using the Wantai? assay.RESULTS HEV is endemic in the region with a seroprevalence of 27.9%(n = 324/1161) 95%CI: 25.3%-30.5%(21.9% when age-adjusted) with no significant differences between ethnic groups or HIV status. Seroprevalence in children is low but rapidly increases in early adulthood. With univariate analysis, age ≥ 30 years old, pork and bacon/ham consumption suggested risk. In the multivariate analysis, the highest risk factor for HEV Ig G seropositivity(OR = 7.679, 95%CI: 5.38-10.96, P < 0.001) was being 30 years or older followed by pork consumption(OR = 2.052, 95%CI: 1.39-3.03, P < 0.001). A recent clinical case demonstrates that HEV genotype 3 may be currently circulating in the Western Cape.CONCLUSION Hepatitis E seroprevalence was considerably higher than previously thought suggesting that hepatitis E warrants consideration in any patient presenting with an unexplained hepatitis in the Western Cape, irrespective of travel history, age or ethnicity. | Richie G Madden Sebastian Wallace Mark Sonderup Stephen Korsman Tawanda Chivese Bronwyn Gavine Aniefiok Edem Roxy Govender Nathan English Christy Kaiyamo Odelia Lutchman Annemiek A van der Eijk Suzan D Pas Glynn W Webb Joanne Palmer Elizabeth Goddard Sean Wasserman Harry R Dalton C Wendy Spearman | 2016 | World Journal of Gastroenterology2016，22，44： | 0 |
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