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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | Noninvasive indocyanine green plasma disappearance rate predicts early complications,graft failure or death after liver transplantation显示文摘BACKGROUND:Early detection of graft malfunction or postoperative complications is essential to save patients and organs after orthotopic liver transplantation (OLT).Predictive tests for graft dysfunction are needed to enable earlier implementation of organ-saving interventions following transplantation.This study was undertaken to assess the value of indocyanine green plasma disappearance rates (ICG-PDRs) for predicting postoperative complications,graft dysfunction and patient survival following OLT.METHODS:Eighty-six patients undergoing OLT were included in this single-centre trial.ICG-PDR was assessed daily for the first 7 days following OLT.Endpoints were graft loss or death within 30 days and postoperative complications,graft loss,or death within 30 days.RESULTS:Postoperative complications of 31 patients included deaths (12 patients) or graft losses.ICG-PDR was significantly different in patients whose endpoints were graft loss or death beginning from day 3 and in those whose endpoints were graft loss,death,or postoperative complications beginning from day 4 after OLT.For day 7 measurements,receiver operating characteristic curve analysis revealed an ICG-PDR cut-off for predicting death or graft loss of 9.6% per min (a sensitivity of 75.0%,a specificity of 72.6%,positive predictive value 0.35 negative predictive value 0.94).For prediction of graft loss,death or postoperative complications,the ICG-PDR cut-off was 12.3%per min (a sensitivity of 68.9%,a specificity of 66.7%,positive predictive value 0.57,negative predictive value 0.77).CONCLUSIONS:ICG-PDR measurements on postoperative day 7 are predictive of early patient outcomes following OLT.The added value over that of routinely determined laboratory parameters is low. | Lutz Schneider Martin Spiegel Sebastian Latanowicz Markus A Weigand Jan Schmidt Jens Werner Wolfgang Stremmel Christoph Eisenbach | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 6 |
| 3 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 4 | Complications following internal fixation of unstable distal radius fracture with a pahnar lockingplate 显示文摘 | Arora R Lutz M Hennerbichler A | 2007 | J Orthop Trauma2007，21，5： | 1 |
| 5 | Efficacy of interferon-gamma and amphotericin B for the treatment of systemic murine histoplasmosis显示文摘 | Clemons K V Lutz J E Stevens D A | 2001 | Microbes Infect2001，3，： | 1 |
| 6 | Optimal LPTV -aware bit loading in broadband PLC 显示文摘 | Muharrem A T Erik P Lutz L | 2013 | IEEE Transactions on Communications2013，61，12： | 1 |
| 7 | Crystallization and characterization of a new magnesium sulfate hydrate MgSO4 · 11H2O显示文摘 | Genceli F E Lutz M Spek A L | 2007 | Cryst Growth Des2007，7，： | 1 |
| 8 | Clinical failure of vancomycin treatment of Staphylococcus aureus infection in A Tertiary Care Hespital in-seuthem Brazil显示文摘 | Lutz L Machado A Kuplich N | 2003 | Braz J Infect Dis2003，7，： | 1 |
| 9 | Reduction of breast carcinoma tumor growth and lung colonization by overexpression of the soluble urokinasetype plasminogen activator receptor (CD87)显示文摘 | Kruger A Soeltl R Lutz V | 2000 | Cancer Gene Ther2000，7，2： | 1 |
| 10 | Dose reduction in subsecond multislice spiral CT examination of children by online tube current modulation显示文摘 | Greess H Lutze J Nomayr A | 2004 | Eur Radiol2004，14，6： | 1 |
| 11 | Complications following in- ternal fixation of unstable distal radius fracture with a palmar locking plate 显示文摘 | Arora R Lutz M Hennerbichler A | 2007 | J Orthop Trauma2007，21，5： | 1 |
| 12 | Complicationsfollowing internal fixation, of unstable distal radius fracturewith a palmar locking-plate 显示文摘 | Aiora R Lutz M Hennerbichler A | 2007 | J Orthop Trauma2007，21，316： | 1 |
| 13 | Larval development of the northern horse mussel, Modiolus modiolus L, including a comparison with the larvae of Mytilus edulis L as an aid in planktonic identification显示文摘 | de Schweinitz E H Lutz R A | 1976 | Biol Bull1976，150，34： | 1 |
| 14 | Remediation of U ( Ⅵ ) - contaminated water using zero - valent iron 显示文摘 | Abdelouas A Lutze W Nuttall E | 1999 | Earth & Planetary Sciences1999，328，： | 1 |
| 15 | Expression of functional kappa opioid receptors on murine dendritic cells显示文摘 | Kirst A Wack C Lutz WK | 2008 | Immunol Lett2008，4，： | 1 |
| 16 | Core decom- pression and osteonecrosis intervention rod in osteonecrosis of the femoral head: clinical outcome and finite element analysis 显示文摘 | Floerkemeier T Lutz A Nackenhorst U | 2011 | Int Orthop2011，35，10： | 1 |
| 17 | Complications fol- lowing internal fixation of unstable distal radius fracture with a palmar locking-plate显示文摘 | Arora R Lutz M Hennerbichler A | 2007 | J Orthop Trauma2007，21，5： | 1 |
| 18 | Defining and measuring rec- reational shopper identity 显示文摘 | Guiry M Magi A W Lutz R J | 2006 | Journal of the Academy of Marketing Science2006，54，1： | 1 |
| 19 | The hydrogen-fueled internal combustion engine:a technical review显示文摘 | White C M Steeper R R Lutz A E | 2006 | InternationalJournal of Hydrogen Energy2006，31，10： | 1 |
| 20 | Calibration of meteosat water vapor channel observations with independent satellite observations 显示文摘 | Stephen A Tjemkes Konig M Lutz Hans-Joachim | 2001 | Journal of geophysical research2001，106，6： | 1 |
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