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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Expression Profiling Identifies Candidate Genes for Fiber Yield and Quality显示文摘Gene expression profiling at early stages(0~2 DPA) of fiber development in Gossypium hirsutum identified a number of transcription factors which were down regulated in fiberless mutants relative to wild type controls and which could play a role in controlling early fiber development.Chief among these was GhMYB25,a Mixta-like MYB gene.Transgenic GhMYB25-silenced cotton | LLEWELLYN D J MACHADO A AI-GHAZI Y DENNIS E S | 2008 | 棉花学报2008，20，S1： | 3 |
| 3 | Pentoxifylline enhances the protective effects of hypertonic saline solution on liver ischemia reperfusion injury through inhibition of oxidative stress显示文摘BACKGROUND:Liver ischemia reperfusion(IR)injury triggers a systemic inflammatory response and is the main cause of organ dysfunction and adverse postoperative outcomes after liver surgery.Pentoxifylline(PTX)and hypertonic saline solution(HTS)have been identified to have beneficial effects against IR injury.This study aimed to investigate if the addition of PTX to HTS is superior to HTS alone for the prevention of liver IR injury. | Vinicius Rocha-Santos Estela RR Figueira Joel A Rocha-Filho Ana MM Coelho Rafael Soraes Pinheiro Telesforo Bacchella Marcel CC Machado Luiz AC D'Albuquerque | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 4 | Pentoxifylline 通过 TNF- 合成和 TGF-1 基因表示的下面规定改进肝新生显示文摘 AIM:To investigate the mechanism of pentoxifylline(PTX)improvement in liver regeneration.RESULTS:Rats were randomized into 4 groups:Control rats;Sham-sham-operation rats;Saline-70% hepatectomy plus saline solution;PTX-70%hepatectomy plus PTX.At 2 and 6 h after hepatectomy,aspartate aminotransferase,alanine aminotransferase,tumor necrosis factor(TNF)-α and interleukin-6(IL-6)serum and hepatic tissue levels were determined.Tumor growth factor(TGF)-β1 gene expression in liver tissue was evaluated 24 h after hepatectomy by quantitative reverse transcriptase polymerase chain reaction analysis.Proliferation was analyzed by mitotic index and proliferating cell nuclear antigen(PCNA)staining 48 h after hepatectomy.RESULTS:TNF-α and IL-6 serum levels increased at 2 and 6 h after hepatectomy.At 2 h after hepatectomy serum PTX was reduced but not hepatic levels of TNF-α and IL-6.A decrease in liver TGF-β1 gene expression and an increase in mitotic index and PCNA after hepatectomy were observed in the PTX treatment group in comparison to the saline group.CONCLUSION:PTX improves liver regeneration by a mechanism related to down regulation of TNF-α production and TGF-β1 gene expression. | Rodrigo Bronze Martino Ana Maria Mendona Coelho Márcia Saldanha Kubrusly Regina Leito Sandra Nassa Sampietre Marcel Cerqueira Cesar Machado Telesforo Bacchella Luiz Augusto Carneiro D’Albuquerque | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 2 |
| 5 | Beneficial effects of adenosine triphosphate-sensitive K^+ channel opener on liver ischemia/reperfusion injury显示文摘AIM:To investigate the effect of diazoxide administration on liver ischemia/reperfusion injury.METHODS:Wistar male rats underwent partial liver ischemia performed by clamping the pedicle from the medium and left anterior lateral segments for 1 h under mechanical ventilation.They were divided into 3 groups:Control Group,rats submitted to liver manipulation,Saline Group,rats received saline,and Diazoxide Group,rats received intravenous injection diazoxide(3.5 mg/kg) 15 min before liver reperfusion.4 h and 24 h after reperfusion,blood was collected for determination of aspartate transaminase(AST),alanine transaminase(ALT),tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),nitrite/nitrate,creatinine and tumor growth factor-β1(TGF-β1).Liver tissues were assembled for mitochondrial oxidation and phosphorylation,malondialdehyde(MDA) content,and histologic analysis.Pulmonary vascular permeability and myeloperoxidase(MPO) were also determined.RESULTS:Four hours after reperfusion the diazoxide group presented with significant reduction of AST(2009 ± 257 U/L vs 3523 ± 424 U/L,P = 0.005); ALT(1794 ± 295 U/L vs 3316 ± 413 U/L,P = 0.005); TNF-α(17 ± 9 pg/mL vs 152 ± 43 pg/mL,P = 0.013; IL-6(62 ± 18 pg/mL vs 281 ± 92 pg/mL); IL-10(40 ± 9 pg/mL vs 78 ± 10 pg/mL P = 0.03),and nitrite/nitrate(3.8 ± 0.9 μmol/L vs 10.2 ± 2.4 μmol/L,P = 0.025) when compared to the saline group.A significant reduction in liver mitochondrial dysfunction was observed in the diazoxide group compared to the saline group(P < 0.05).No differences in liver MDA content,serum creatinine,pulmonary vascular permeability and MPO activity were observed between groups.Twenty four hours after reperfusion the diazoxide group showed a reduction of AST(495 ± 78 U/L vs 978 ± 192 U/L,P = 0.032); ALT(335 ± 59 U/L vs 742 ± 182 U/L,P = 0.048),and TGF-β1(11 ± 1 ng/mL vs 17 ± 0.5 ng/mL,P = 0.004) serum levels when compared to the saline group.The control group did not present alterations when compared to the diazoxide and saline groups.CONCLUSION:Diazoxide maintains liver mitochondrial function,increases liver tolerance to ischemia/reperfusion injury,and reduces the systemic inflammatory response.These effects require further evaluation for using in a clinical setting. | Mateus Antunes Nogueira Ana Maria Mendona Coelho Sandra Nassa Sampietre Rosely Antunes Patzina Fabiano Pinheiro da Silva Luiz Augusto Carneiro D'Albuquerque Marcel Cerqueira Cesar Machado | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 6 | Aquaporins in the central nervous system显示文摘 | Venero JL Vizuete ML Machado A | 2001 | Prog Neurobiol2001，63，： | 2 |
| 7 | Activity of enzymes involved in the nitrogen metabolism in different maize genotypes 显示文摘 | Machado A T Magalhaes J R Magnavaca R | 1992 | Revista Gbrasileira de Fisiologia Vegetal1992，4，1： | 1 |
| 8 | A structural,functional and molecular analysis of plastids of the holoparasites Cuscuta reflexa and Cuscuta europaea显示文摘 | MACHADO M A ZETSCHE K | 1990 | Planta1990，181，： | 1 |
| 9 | Systems for therapeutic angiogenesis in tissue engineering显示文摘 | Soker S Machado M Atala A | 2000 | World J Urol2000，18，： | 1 |
| 10 | Study of physiological parameters for the selection of maize genotypes efficient in ammonium uptake 显示文摘 | MAGALHAES J R PURCINO A A C MACHADO A T | 1990 | Documentos EmpresaCapixaba de Pesquisa Agropecuaria1990，65，： | 1 |
| 11 | Probing the mechanism of the Heck reaction with arene diazonium salts by electrospray mass and tandem mass spectrometry 显示文摘 | SABINO A A MACHADO A H L ROQUE C D | 2004 | Angew Chem Int Ed2004，43，19： | 1 |
| 12 | Potentiation of 5-fluorouracil encapsulated in zeolites as drug delivery systemsfor in vitro models of colorectal carcinoma显示文摘 | Yilaa N Amorim R Machado A F | 2013 | Colloids Surf BBiointerfaces2013，，： | 1 |
| 13 | Production of soluble enzymatic protein hydrolysate from industrially defatted undehulled sunflower meal 显示文摘 | Parrado J Bautista J Machado A | 1991 | Journal of Agriculture and Food Chemistry1991，39，4： | 1 |
| 14 | In vitro activity of Brazilian medicinal plants,naturally occurring naphthoquinones and their analogues,against methicillin-resistant staphylococcus aureus显示文摘 | MACHADO T B PINTO A V PINTO M C | 2003 | Int J Antimicrob Ag2003，21，3： | 1 |
| 15 | Analysis of the Consumption of Artistic- cultural Goods and Services in Brazil 显示文摘 | Diniz S C Machado A F | 2011 | Journal of Cultural Eco- nomics2011，35，1： | 1 |
| 16 | New oxidation catalysts based on iron(III) porphyrins immobilized on Mg-Al layered double hydroxides modified with triethanolamine 显示文摘 | CASTRO K A D F BAIL A GROSZEWICZ P B MACHADO G S SCHREINER W H WYPYCH F NAKAGAKI S | 2010 | Appl Catal A: Gen2010，386，： | 1 |
| 17 | Recovery of soianesol from tobacco as a value- added byproduct for alternative applications显示文摘 | MACHADO P A FU H KRATOCHVIL R J | 2010 | Bioresource technology2010，101，3： | 1 |
| 18 | Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients显示文摘 | Santos Savio A Machado Diaz AC Chico Capote A | 2015 | BMC Musculoskelet Disord2015，，： | 1 |
| 19 | Clinical failure of vancomycin treatment of Staphylococcus aureus infection in A Tertiary Care Hespital in-seuthem Brazil显示文摘 | Lutz L Machado A Kuplich N | 2003 | Braz J Infect Dis2003，7，： | 1 |
| 20 | Towards property oriented testing 显示文摘 | MACHADO P D L SILVA D A MOTA A C | 2007 | Electrical Notes in Theoretical Computer Science2007，184，： | 1 |
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