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| 1 | Search for naive human pluripotent stem cells显示文摘Normal mouse pluripotent stem cells were originally derived from the inner cell mass(ICM) of blastocysts and shown to be the in vitro equivalent of those pre-implantation embryonic cells, and thus were called embryonic stem cells(ESCs). More than a decade later, pluripotent cells were isolated from the ICM of human blastocysts. Despite being called human ESCs, these cells differ significantly from mouse ESCs, including different morphology and mechanisms of control of pluripotency, suggesting distinct embryonic origins of ESCs from the two species. Subsequently, mouse pluripotent stem cells were established from the ICMderived epiblast of post-implantation embryos. These mouse epiblast stem cells(Epi SCs) are morphological and epigenetically more similar to human ESCs. This raised the question of whether cells from the human ICM are in a more advanced differentiation stage than their murine counterpart, or whether the available culture conditions were not adequate to maintain those human cells in their in vivo state, leading to a transition into Epi SC-like cells in vitro. More recently, novel culture conditions allowed the conversion of human ESCs into mouse ESC-like cells called nave(or ground state) human ESCs, and the derivation of nave human ESCs from blastocysts. Here we will review the characteristics of each type of pluripotent stem cells, how(and whether) these relate to different stages of embryonic development, and discuss the potential implications of nave human ESCs in research and therapy. | Simone Aparecida Siqueira Fonseca Roberta Montero Costas Lygia Veiga Pereira | 2015 | World Journal of Stem Cells2015，7，3： | 2 |
| 2 | Pigment gallstone pathogenesis: Slime production by biliary bacteria is more important than beta-glucuronidase production显示文摘 | Lygia Stewart M.D. Rosio Ponce Adair L. Oesterk J. McLeod Griffiss M.D. Lawrence W. Way M.D | 2000 | Journal of Gastrointestinal Surgery2000，，5： | 2 |
| 3 | Right hepatic artery injury associated with laparoscopic bile duct injury: Incidence, mechanism, and consequences显示文摘 | Lygia Stewart Thomas N. Robinson Crystine M. Lee Kingsway Liu Karen Whang Lawrence W. Way | 2004 | Journal of Gastrointestinal Surgery2004，，5： | 2 |
| 4 | Pigment Gallstones Form as a Composite of Bacterial Microcolonies and Pigment Solids显示文摘 | LYGIA STEWART ALISON L. SMITH CARLOS A. PELLEGRINI ROGER W. MOTSON LAWRENCE W. WAY | 1987 | Annals of Surgery1987，，3： | 1 |
| 5 | Laparoscopic bile duct injuries: timing of surgical repair does not influence success rate: a mul- tivariate analysis of factors influencing surgical outcomes显示文摘 | Lygia Stewar Lawrence W | 2009 | International Hepato-Pancreato-Biliary Association2009，11，： | 1 |
| 6 | Right hepatic artery injury associated with laparoscopic bile duct injury: inci- dence, mechanism, and consequences显示文摘 | LYGIA S THOMAS N ROBINSON M | 2004 | Journal of Gastroin- testinal Surgey2004，8，5： | 1 |
| 7 | High frequen-cy of fumigants and other toxic gases in imported freight contain-ers-an underestimated occupational and community health risk显示文摘 | Xaver Baur’Bemd Poschadel Lygia Therese Budnik | 2010 | Occup Environ Med2010，67，3： | 1 |
| 8 | Influence of intracranial hemorrhage and neonatal seizures on the neurological and psychomotor development of premature infants at Hospital de Clinicas de Porto Alegre,Brazil显示文摘 | Ohlweiler Lygia Silva Alexandre Rodrigues da Barros Sonja Verginia | 2003 | Arquivos de NeuroPsiquiatria2003，61，4： | 1 |
| 9 | Cholangitis: Bacterial virulence factors that facilitate cholangiovenous reflux and tumor necrosis factor-alpha production显示文摘 | Lygia Stewart M.D. Adair L. Oesterle J. McLeod Grifiss M.D. Gary A. Jarvis Ph.D. Lawrence W. Way M.D | 2003 | Journal of Gastrointestinal Surgery2003，，2： | 1 |
| 10 | Tumors of the Ampulla of Vater: Histopathologic Classification and Predictors of Survival显示文摘 | Jonathan T. Carter James P. Grenert Laura Rubenstein Lygia Stewart Lawrence W. Way | 2008 | Journal of the American College of Surgeons2008，，2： | 1 |
| 11 | Right hepatic artery injury associated with laparoscopic bile duct injury: Incidence, mechanism, and consequences显示文摘 | Lygia Stewart M.D. Thomas N. Robinson M.D. Crystine M. Lee M.D. Kingsway Liu M.D. Karen Whang M.D. Lawrence W. Way M.D | 2004 | Journal of Gastrointestinal Surgery2004，，5： | 1 |
| 12 | Right hepatic artery injury associated with laparoscopic bile duct injury: Incidence, mechanism, and consequences显示文摘 | Lygia Stewart M.D. Thomas N. Robinson M.D. Crystine M. Lee M.D. Kingsway Liu M.D. Karen Whang M.D. Lawrence W. Way M.D | 2004 | Journal of Gastrointestinal Surgery2004，，5： | 1 |
| 13 | Local resection of ampullary tumors显示文摘 | Adam T. Meneghetti M.D. Bassem Safadi M.D. Lygia Stewart M.D. Lawrence W. Way M.D | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 1 |
| 14 | Iatrogenic Biliary Injuries: Identification, Classification, and Management显示文摘 | Lygia Stewart | 2014 | Surgical Clinics of North America2014，，： | 1 |
| 15 | Pathogenesis of pigment gallstones in western societies: The central role of bacteria显示文摘 | Lygia Stewart M.D. Adair L. Oesterle Ihsan Erdan Ph.D. J. MacLeod Griffiss M.D. Lawrence W. Way M.D | 2002 | Journal of Gastrointestinal Surgery2002，，6： | 1 |
| 16 | Bacteria Entombed in the Center of Cholesterol Gallstones Induce Fewer Infectious Manifestations than Bacteria in the Matrix of Pigment Stones显示文摘 | Lygia Stewart MD J. McLeod Griffiss MD Gary A. Jarvis PhD Lawrence W. Way MD | 2007 | Journal of Gastrointestinal Surgery2007，，10： | 1 |
| 17 | Phytotoxic effect of Sesbania virgata(Cav.) Pers.on seeds of agronomic and forestry species显示文摘Sesbania virgata(Cav.) Pers.is a pioneer species native to South America able to release allelochemicals that affect germination and development of other plant species.The aim of this work was to evaluate the allelopathic effect of S.virgata on the germination and development of co-occurring species from gallery forest and on agronomic species.Two forest native species,Enterolobium contortisiliquum(Vell.) Morong and Sapindus saponaria L.,and two agronomic species(these as control),Oryza sativa L.and Solanum lycopersicum L.were used in the lab and greenhouse assays with seeds and leaf extracts of S.virgata.Agronomic species were more affected than native species when co-germinated with seeds of S.virgata.The germination percentage and speed germination index of the agronomic species were reduced in both in vitro and greenhouse assays.In the same assays,the seeds of native species showed no significant differences in the parameters mentioned.However,the initial growth of the four species assayed was affected,with reduction in plant length and shoot diameter followed by significant reduction in plantlet shoot and root weights.In the assays with irrigation of S.virgata leaf extracts,no significant inhibitory effects on germination were observed for all species.Height and shoot diameter of the native species were not affected by the leaf extracts,nor were fresh and dry weights.However,these parameters increased in the agronomic species as they were irrigated with leaf extracts.Based on our data we conclude that seed leachates of S.virgata affect germination and seedling development of other species,suggesting that its invasive behavior is due mainly to seed allelochemicals.Although with less pronounced effects on native species,allelopathy of S.virgata might also influence Interspecific competition in its natural environment. | Vera Lygia El Id Bárbara Vale da Costa Daiane Salete Broch Mignoni Marina Belloni Veronesi Kelly Simoes Marcia Regina Braga Nelson Augusto dos Santos Junior | 2015 | Journal of Forestry Research2015，26，2： | 0 |
| 18 | Hyponatremia is associated with more severe biliary disease显示文摘BACKGROUND Sodium level is an important clinical predictor of complex biliary disease.Hyponatremia has been observed in conjunction with biliary disease,however the nature of this association remains unclear.AIM To investigate the association between serum sodium and severe biliary disease.METHODS Of 920 patients with gallstone disease treated at the SFVA Hospital from 1989-2019 were studied.We conducted multivariate analyses of correlation between sodium level and biliary disease severity,the presence/location of biliary bacteria,and other factors.Minimum sodium level pre-intervention was collected.Gallstones,bile,and blood(as relevant)were cultured.Illness severity was characterized:(1)None(no infectious manifestations);(2)Systemic inflammatory response syndrome;(3)Severe illness(gangrenous cholecystitis,cholangitis,necrotizing pancreatitis);and(4)Multiple organ dysfunction syndrome(bacteremia,hypotension,organ failure).Comorbidity was defined using the Charlson Comorbidity Index(CCI).RESULTS Decreased sodium level significantly correlated with worsening illness severity,ascending bacterial infection,gangrenous changes,elevated CCI score,increasing age,male sex,and glucose.On multivariate analysis,all factors,except age,gender and glucose,independently correlated with sodium level and factors were additive.CONCLUSION This unique study is the first to explore,with such granularity,the relationship between biliary disease and sodium.No prior studies have examined specific culture and clinical data.It illustrates an inverse,independent correlation between illness severity and sodium.Culture data demonstrate that sodium decreases as infection ascends from gallstone colonization to bactibilia to bacteremia.Patient comorbidity and gangrenous changes also independently correlate with sodium on multivariate analysis.Sodium level is an important clinical indicator of disease severity for patients with biliary disease. | Michael John Zobel Lygia Stewart | 2020 | World Journal of Gastrointestinal Surgery2020，12，2： | 0 |
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