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| 1 | Components of health:an analysis in rheumatoid arthritis using quality of life questionnaires and clinical and laboratory variables显示文摘 | Borstlap M Laar M Zant J | 1993 | Ann Rheum Dis1993，52，： | 1 |
| 2 | Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson’s disease(NSTAPS study):a randomised controlled trial显示文摘 | Odekerken V J van Laar T Staal M J | 2013 | Lancet Neurol2013，12，1： | 1 |
| 3 | Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB显示文摘 | Douma S Van Laar T Zevenhoven J | 2004 | Nature2004，430，7003： | 1 |
| 4 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | Stimulation of gap junctional communication:comparison of acycloretionic acid lycopene 显示文摘 | Stahl W von laar J Martin H D etal | 2000 | Arch Biochem Biophys2000，373，： | 1 |
| 7 | In vivo flow territory mapping of major brain feeding arteries 显示文摘 | Van Laar PJ Hendrikse J Golay X | 2006 | Neuroimage2006，29，1： | 1 |
| 8 | Pain treatment inarthritis-related pain : beyond NSAIDs 显示文摘 | VAN LAAR M PERGOLIZZI J V JR MELLINGHOFF H U | 2012 | OpenRheumatol J2012，6，： | 1 |
| 9 | Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB显示文摘 | Douma S van Laar T Zevenhoevn J | 2004 | Nature2004，430，7003： | 1 |
| 10 | Analysing crop yield and plant quality in an intercropping system using an eco-physiological model for interplant competition显示文摘 | Baumann D T Bastiaans L Goudriaan J van Laar H H Kropff M J | 2002 | Agricultural Systems2002，，73： | 1 |
| 11 | Ethnic enclaves and the dynamics of social Identity on the college campus:the good, the bad, and the ugly 显示文摘 | Sidanius J Laar C V Levin S Sinclair S | 2004 | Journal of Personality Social Psy- chology2004，87，1： | 1 |
| 12 | In vivo flow territory mapping of major brain feeding arteries显示文摘 | van Laar PJ Hendrikse J Golay X | 2006 | Neuroimage2006，29，： | 1 |
| 13 | The fetal variant of the circle of Willis and its influence on the cerebral collateral circulation 显示文摘 | van Raat AF Mali WP van Laar P J | 2006 | Cerebrovasc Dis2006，22，4： | 1 |
| 14 | Brain perIusion territory imaging: methods and clinical applications of selec- tive arterial spin labeling MR imaging 显示文摘 | Van Laar PJ Van der Grond J Hendrikse J | 2008 | Radiology2008，246，： | 1 |
| 15 | Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors显示文摘 | Peart M J Smyth GK van Laar RK | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 16 | Cerebral border zones between distal end branches of intracranial arteries: MR imaging 显示文摘 | Hendrikse J Petersen ET van Laar PJ | 2008 | Radiology2008，24，6： | 1 |
| 17 | Brain perfusionterritory imaging: methods and clinical applications ofselective arterial spin-labeling MR imaging 显示文摘 | van Laar PJ van der Grond J Hendrikse J | 2008 | Radiolo-gy2008，246，2： | 1 |
| 18 | MIMO instantaneous blind identification based on second-order temporal structure 显示文摘 | Laar J Moonen M and Sommen P C W | 2008 | IEEE Transactions on Signal Processing2008，56，9： | 1 |
| 19 | Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB显示文摘 | Douma S Van Laar T Zevenhoven J | 2004 | Nature2004，430，7003： | 1 |
| 20 | Metformin associated lactic acidosis:incidence and clinical correlation with metformin serum concentration measurements显示文摘 | VAN BERLO-VAN D E LAAR I R VERMEIJ C G DOORENBOS C J | 2011 | J Clin PHarm Ther2011，36，： | 1 |
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