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| 1 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 2 | Supercritical fluid extraction and high -performance liquid chromatography -fluorescence detection method for pelycyclic aromatic hydrocarbons investigation in vegetable oil显示文摘 | Lage Yusty M A Cortizo Davina J L | 2005 | Food Control2005，16，： | 1 |
| 3 | Angiotensin Ⅱ contributes to arterial compliance in congestive heart failure显示文摘 | Lage SG Kopel L Medeiros CC | 2002 | Am J Physiol Heart Circ Physiol2002，283，4： | 1 |
| 4 | Two Types of Non-Linear Pressure-Drop Versus Flow-Rate Relation Observed for Saturated Porous Media 显示文摘 | Lage J L Antohe B V Nield D A | 1997 | ASME Fluids Engine1997，119，3： | 1 |
| 5 | Two Types of Non- linear Pressure-Drop Versus Flow-Rate Relation Ob- served for Saturated Porousmedia显示文摘 | Lage J L Antohe B V Nield D A | 1997 | Journal of Fluids Engineering1997，119，3： | 1 |
| 6 | Anti-TNF therapy for polymyal- gia rheumatica:report of 99 cases and review of the literature 显示文摘 | Aikawa NE Pereira RM Lage L | 2012 | Clin Rheumato12012，31，3： | 1 |
| 7 | Removal of contaminant generated by a discrete source in a slot ventilated enclosure显示文摘 | Lage J L Bejan A | 1992 | International Journal of Heat and Mass Transfer1992，35，5： | 1 |
| 8 | On the numerical solution and optimization of styrene polymerization in tubular reactors显示文摘 | Costa E F Lage P L C Biscaia E C | 2003 | Computers and Chemical Engineering2003，27，11： | 1 |
| 9 | Removal of contaminant generated by a discrete source in a slot ventilated enclosure显示文摘 | Lage J L Bejan A | 1992 | International Journal of Heat and Mass Transfer1992，35，5： | 1 |
| 10 | Tooth loss in individuals, un- der periodontal maintenance therapy: 5-year prospective study 显示文摘 | Costa F ~ Lages E J Cota L O eta( | 2014 | J Periodontal Res2014，49，1： | 1 |
| 11 | The Reloual Scale: A Measure of Relationship Quality in Export Market Ventures显示文摘 | Lages C Lages C R Lages L F | 2005 | Journal of Business Reseach2005，58，8： | 1 |
| 12 | Positive association between MET allele ( BDNF Va166Met polymorphism) and obsessive-compulsive disorder显示文摘 | ROCHA F F MALLOY-DINIZ L LAGE N V | 2010 | Rev Bras Psiquiatr2010，32，3： | 1 |
| 13 | The RELQUAL scale:a measure of relationship quality in export market ventures 显示文摘 | LAGES C LAGES C R LAGES F L | 2005 | Journal of Business Research2005，58，8： | 1 |
| 14 | Modified Hazen-Dupuit-Darcy Model for Forced Convection of a Fluid With Tempera- ture Dependent Viscosity显示文摘 | Narasimhan A Lage J L | 2001 | ASME J Heat Transfer2001，123，： | 1 |
| 15 | The relationship between the Met allele of the BDNF Va166Met polymorphism and impairments in decision making under ambiguity in patients with obsessivecompulsive disorder 显示文摘 | ROCHA F F MALLOY-DINIZ L LAGE N V | 2011 | Genes Brain Behav2011，10，5： | 1 |
| 16 | A modified form of the κ-ε modle for turbulent flow of an incompressible fluid in porous media显示文摘 | Getachew D Minkowycz W J Lage J L | 2000 | International Journal of Heat and Mass Transfer2000，43，3： | 1 |
| 17 | Forced Convection of a Fluid With Temperature-Dependent Viscosity Through a Porous Medium Channel显示文摘 | Narasimhan A Lage J L | 2001 | Numer Heat Transfer2001，40，8： | 1 |
| 18 | Contextual Factors and the Creativity of Frontline Employees:The Mediating Effects of Role Stress and Intrin- sic Motivation显示文摘 | Coelho F Augusto M Lages L F | 2011 | Journal of Retailing2011，87，1： | 1 |
| 19 | Numerical characterization of micro heat exchangers using experimentally tested porous aluminum layers 显示文摘 | Antohe B V Lage J L Price D C | 1996 | Int J Heat and Fluid Flow1996，17，6： | 1 |
| 20 | Validation and Simplification of Bethesda Guidelines for Identifying Apparently Sporadic Forms of Colorectal Carcinoma with Microsatellite Instability显示文摘 | Cravo M L Fidalgo P O Lage P A | 1999 | Cancer1999，85，4： | 1 |
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