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| 1 | Is rectal indomethacin effective in preventing of post-endoscopic retrograde cholangiopancreatography pancreatitis?显示文摘AIM:To investigate the effectiveness of rectally administered indomethacin in the prophylaxis of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis and hyperamylasaemia in a multicentre study.METHODS:A prospective,randomised,placebocontrolled multicentre study in five endoscopic units was conducted on 686 patients randomised to receive a suppository containing 100 mg indomethacin,or an inert placebo,10-15 min before ERCP.Post-ERCP pancreatitis and hyperamylasaemia were evaluated 24 h following the procedure on the basis of clinical signs and laboratory parameters,and computed tomography/magnetic resonance imaging findings if required.RESULTS:Twenty-one patients were excluded because of incompleteness of their data or because of protocol violation.The results of 665 investigations were evaluated:347 in the indomethacin group and 318 in the placebo group.The distributions of the risk factors in the two groups did not differ significantly.Pancreatitis developed in 42 patients(6.3%):it was mild in34(5.1%)and severe in eight(1.2%)cases.Hyperamylaesemia occurred in 160 patients(24.1%).There was no significant difference between the indomethacin and placebo groups in the incidence of either postERCP pancreatitis(5.8%vs 6.9%)or hyperamylasaemia(23.3%vs 24.8%).Similarly,subgroup analysis did not reveal any significant differences between the two groups.CONCLUSION:100 mg rectal indomethacin administered before ERCP did not prove effective in preventing post-ERCP pancreatitis. | Zoltán Dbrnte Zoltán Szepes Ferenc Izbéki Judit Gervain László Lakatos Gyula Pécsi Miklós Ihász Lilla Lakner Erzsébet Toldy László Czakó | 2014 | World Journal of Gastroenterology2014，20，29： | 16 |
| 2 | microRNAs: Fad or future of liver disease显示文摘microRNAs (miRs) are small non-coding RNAs that regulate both mRNA and protein expression of target genes, which results in alterations in mRNA stability or translation inhibition. miRs influence at least one third of all human transcripts and are known regulators of various important cellular growth and differentiation factors. miRs have recently emerged as key regulatory molecules in chronic liver disease. This review details recent contributions to the field of miRs that influence liver development and the broad spectrum of disease, from non-alcoholic fatty liver disease to fibrosis/cirrhosis, with particular emphasis on hepatic stellate cells and potential use of miRs as therapeutic tools. | Ashley M Lakner Herbert L Bonkovsky Laura W Schrum | 2011 | World Journal of Gastroenterology2011，17，20： | 13 |
| 3 | Chiral aynthos via chloroperoxidase catalysis显示文摘 | HAGER L P LAKNER F J BASAVAPATHRUNI A | 1998 | J Mol Catal B E NZYM1998，234，2： | 1 |
| 4 | Chiral aynthos via chloroperoxidase catalysis显示文摘 | Hager L P Lakner F J Basavapathruni A | 1998 | J Mol Catal Enzyme1998，143，5： | 1 |
| 5 | Portfolio optimization with downside constraints显示文摘 | Lakner P Nygren L M | 2006 | Mathematical Finance2006，16，2： | 1 |
| 6 | Determination of 4- hydroxy 2,5-dimethyl 3 ( 2 H)-furanone and 2 (or 5)-ethyl-4- hydroxy-5 ( or 2)-methyl 3 ( 2H)-furanone in pentose sugar based Maillard model systems by isotope dilution assays显示文摘 | BLANK I FAY L B LAKNER F J | 1997 | Journal of Agricultural and Food Chemistry1997，45，7： | 1 |
| 7 | Interethnic differences of CYP2C9 alleles in healthy Hungarian and Roma population samples: relationship to worldwide allelic frequencies显示文摘 | Sipeky C Lakner L Szabo M | 2009 | Blood Cells Mol Dis2009，43，3： | 1 |
| 8 | Inhibitory effects of microRNA 19bin hepatic stellate cell-mediated fibrogenesis显示文摘 | LAKNER A M STEUERWALD N M WALLINGT L | 2012 | Hepatology2012，56，： | 1 |
| 9 | 显示文摘 | Chen M Donzel L Lakner M | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 10 | Portfolio Optimization with Downside Constraints 显示文摘 | LAKNER P NYGREN L M | 2006 | Mathematical Finance2006，16，2： | 1 |
| 11 | Perceived risk and mail order shopping for apparel 显示文摘 | SIMPSON L LAKNER H B | 1993 | Journal of Consumer Studies Home Economies1993，17，4： | 1 |
| 12 | Postinfectious irritable bowel syndrome 显示文摘 | Dobronte Z Lakner L Sarang K | 2006 | Orv Hetil2006，147，43： | 1 |
| 13 | Portfolio optimization with downside constraints显示文摘 | Lakner P and Nygren L M | 2006 | Mathematical Fincance2006，16，2： | 1 |
| 14 | C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn’s disease in Hungarian patients显示文摘 | Lilla Lakner Veronika Cs?ngei Patrícia Sarlós Luca Járomi Enik? Sáfrány Márta Varga Péter Orosz Lili Magyari Judit Bene Pál Miheller Zsolt Tulassay Béla Melegh | 2009 | International Journal of Colorectal Disease2009，，5： | 1 |
| 15 | Chiral synthons viachloroperoxidase catalysis显示文摘 | Hager L P Lakner F J Basavapathruni A | 1998 | J Mol Catal B:Enzymatic1998，5，1234： | 1 |
| 16 | Postinfectious irritable bowel syndrome 显示文摘 | Dobronte Z Lakner L Sarang K | 2006 | Orv Hetil2006，147，43： | 1 |
| 17 | Portfolio optimization with downside constraints 显示文摘 | Lakner P Nygren L M | 2006 | Mathematical Finance2006，16，2： | 1 |
| 18 | Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with H.pylori gastritis显示文摘AIM:To study the role of capsaicin-sensitive afferent nerves in Helicobacter pylori (H.pylori) positive chronic gastritis before and after eradication.METHODS:Gastric biopsy samples were obtained from corpus and antrum mucosa of 20 healthy human subjects and 18 patients with H.pylori positive chronic gastritis (n=18) before and after eradication.Tradi-tional gastric mucosal histology (and Warthin-Starry silver impregnation) and special histochemical examina-tions were carried out.Immunohistochemistry for cap-saicin receptor (TRVP1),calcitonin gene-related peptide (CGRP) and substance P (SP) were carried out by the labeled polymer immunohistological method (Lab VisionCo.,USA) using polyclonal rabbit and rat monoclonal antibodies (Abcam Ltd.,UK).RESULTS:Eradication treatment was successful in 16 patients (89%).Seven patients (7/18,39%) re-mained with moderate complaints,meanwhile 11 pa-tients (11/28,61%) had no complaints.At histological evaluation,normal gastric mucosa was detected in 4 patients after eradication treatment (4/18,22%),and moderate chronic gastritis could be seen in 14 (14/18,78%) patients.Positive immuno-staining for capsaicin receptor was seen in 35% (7/20) of controls,89% (16/18,P < 0.001) in patients before and 72% (13/18,P < 0.03) after eradication.CGRP was positive in 40% (8/20) of controls,and in 100% (18/18,P < 0.001) of patients before and in 100% (18/18,P < 0.001) after eradication.The immune-staining of gastric mucosa for substance-P was positive in 25% (5/20) of healthy con-trols,and in 5.5% (3/18,P > 0.05) of patients before and in 0% of patients (0/18,P > 0.05) after H.pylori eradication.CONCLUSION:Distibution of TRVP1 and CGRP is altered during the development of H.pylori positive chronic gastritis.The immune-staining for TRVP1,CGRP and SP rwemained unchanged before and after H.py-lori eradication treatment.The capsaicin-sensitive affer-entation is an independent from the eradication treat-ment.The 6 wk time period might not be enough time for the restituion of chronic H.pylori positive chronic gastritis.The H.pylori infection might not represent the main pathological factor in the development of chronic | Lilla Lakner András Dmtr Csaba Tóth Imre L Szabó gnes Meczker Rebeka Hajós László Kereskai Gyrgy Szekeres Zoltán Dbrnte Gyula Mózsik | 2011 | World Journal of Gastrointestinal Pharmacology and Therapeutics2011，2，5： | 0 |
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