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| 1 | 高龄对男性生育力的影响显示文摘在过去的几十年里,现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少,而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制,因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述,希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。 | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 3 | The influence of film crystallinity on the coupling efficiency of ZnO optical modulator waveguides显示文摘 | Koch M H Timbrell P Y Lamb R N | 1995 | Semicond Sci Technol1995，10，： | 2 |
| 4 | Signal and construction mechanisms for activation of plant defenses against microbial attack显示文摘 | Lamb C J Lawton M A Dron M | 1989 | Cell1989，56，： | 2 |
| 5 | Not just another BI:faculty-librariancollaboration to guide students through the research process显示文摘 | STEIN L L LAMB J M | 1998 | Research Strategies1998，16，1： | 1 |
| 6 | Barriers and facilitators to consulting hospital clinical ethics committees显示文摘 | Gaudine A Lamb M LeFort SM | 2011 | Nurs Ethics2011，18，6： | 1 |
| 7 | Assessment of intake from the diet显示文摘 | R Kroes D Müller J Lambe M.R.H L?wik J van Klaveren J Kleiner R Massey S Mayer I Urieta P Verger A Visconti | 2002 | Food and Chemical Toxicology2002，，2： | 1 |
| 8 | Heat shock protein antibody titers are reduced by statin therapy in dyslipidemic subjects: a pilot study显示文摘 | GHAYOUR-MOBARHAN M LAMB D J VAIDYA N | 2005 | Angiology2005，56，1： | 1 |
| 9 | Genetic dissection of mammalian fertility pathways显示文摘 | Matzuk M M Lamb D J | 2002 | Nature cell biology2002，8，： | 1 |
| 10 | The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver 显示文摘 | Eyal S Lamb J G Smith-Yockman M | 2006 | Br J Pharmacol2006，149，3： | 1 |
| 11 | A novel Pd/MgAlOx catalyst for NOX storage-reduction显示文摘 | SILLETTI B A ADAMS R T SIGMON S M NIKOLOPOULOS A SPIVEY J J LAMB H H | 2006 | Catal Today2006，114，1： | 1 |
| 12 | Donepezil:A review of its use in Alzheimer's disease 显示文摘 | DOOLEY M LAMB ItM | 2000 | Adis International2000，16，3： | 1 |
| 13 | P-V-T properties of fluids in the system H20CO2q-NaCI: New graphical presentation and implications for fluid inclusion studies显示文摘 | BROWN P E LAMB W M | 1989 | Geochimiea et CosmoehimieaActa1989，53，6： | 1 |
| 14 | Cancers coinciding with childbear- ing: delayed diagnosis during pregnancy?显示文摘 | Lambe M Ekbom A | 1995 | BMJ1995，311，7020： | 1 |
| 15 | Differential long-term expression and methylation of the hygromycin phosphotranspherase(hph)and(b-glucuronidase(gus)genes in transgenic Pearl-Millet(Pennisetum glaucum)callus显示文摘 | LAMB P DINANT M MATAGNE R F | 1995 | Plant Sci1995，108，： | 1 |
| 16 | New 40Ar/39Ar age data and implications for porphyry copper deposits of Mongolia显示文摘 | LAMB M A COX D | 1998 | Economic Geology1998，92，： | 1 |
| 17 | Impact of manure application on soil phosphorus sorption characterisitics and subsequent water quality implications显示文摘 | Laboski C A M Lamb J A | 2004 | Soil Science2004，169，6： | 1 |
| 18 | Incidence of appendicitis during pregnancy显示文摘 | Anderson RE Lambe M | 2001 | Int J Epidermiol2001，30，6： | 1 |
| 19 | Investigation of boiling front during vacuum drying of wood 显示文摘 | Chen Zhangjing Fred M Lamb | 2001 | Wood and Fiber Science2001，35，4： | 1 |
| 20 | Outcome after lung cancer sur'gery:Factors predicting early mortality and major morbidity显示文摘 | Myrdal G Gustafsson G Lambe M | 2001 | Eur J Cardiothorac Surg2001，20，4： | 1 |
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