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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | The fibronectin binding proteins of Staphylococcus aureus are required for adhesion to and invasion of bovine mammary gland cells显示文摘 | Nuijter P J Smith H E | 1999 | FEMS Microbiology Lettres1999，180，1： | 1 |
| 3 | The use of fibrillation eyele length to determine spatial dispersion in electrophysiological properties and to characterize the underlying mechanism of fibrillation显示文摘 | Lammers W J E P Allessie M A llensma P L el al | 1986 | New Trends in Arrhythmias1986，2，1： | 1 |
| 4 | Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development 显示文摘 | Haggstrom AN Lammer E J Schneider RA | 2006 | Pediatrics2006，117，3： | 1 |
| 5 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model显示文摘 | Delnoij E Lammers F A Kuipers J A M | 1997 | Chem Eng Sci1997，52，9： | 1 |
| 6 | Legitimacy moderates the effect of power on approach 显示文摘 | Lammers J Galinsky A D Gordijn E H | 2008 | Psychological Science2008，，6： | 1 |
| 7 | Systemic inflammation in chronic obstructive pulmonary disease显示文摘 | Oudijk E J Lammers JW Koenderman L | 2003 | Eur Respir J Suppl2003，46，： | 1 |
| 8 | Methylated APC and GSTP1 genes in serum DNA correlate with the presence of circulating blood tumor cells and are associated with a more aggressive and advanced breast cancer disease显示文摘 | Matuschek C B(o)lke E Lammering G | 2010 | Eur J Med Res2010，15，： | 1 |
| 9 | Reproductive functions in young fathers and grandfathers显示文摘 | NIESCHLAG E LAMMERS U FREISCHEM C W | 1982 | Clin Endocrinol Metab1982，55，： | 1 |
| 10 | Is the fish embryotoxicity test(FET)with the zebrafish(Danio rerio)a potential alternative for thefish acute toxicity test?显示文摘 | Lammer E Carr G Wendler K | 2009 | Comp Biochem Physiol2009，149，2： | 1 |
| 11 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 12 | Endoluminal stent-grafts for infrarenal abdominal aortic aneurysms显示文摘 | Blum E Voshage G Lammer J | 1997 | N Engl J Med1997，336，： | 1 |
| 13 | Molecular and biological factors in the prognosis of non-small cell lung cancer 显示文摘 | KANTERS S D LAMMERS J W VOEST E E | 1995 | Eur Respir J1995，8，8： | 1 |
| 14 | Maternalpericonceptional vitamin use,genetic variation of infant reduced folate carrier (A80G),and risk of spina bifida显示文摘 | Shaw G M Lammer E J Zhu H | 2002 | Am J Med Genet2002，108，1： | 1 |
| 15 | Congenital anoma- lies and mortality risk in white and black infacts 显示文摘 | Malcoe LH Shaw GM Lammer E J | 1999 | Am J Pub Health1999，，： | 1 |
| 16 | Is the fish embryo toxicity test (FET) with the zebrafish (Danio rerio ) a potential alternative for the fish acute toxicity test ? 显示文摘 | Lammer E Carr G J Wendler K | 2009 | Comparative Biochemistry and Physiology C-Toxicolo- gy & Pharmacology2009，149，2： | 1 |
| 17 | Tumour-targeted uanomedicines:Principles and practice显示文摘 | LAMMERS T HENNINK W E STORM G | 2008 | British Journal of Cancer2008，99，3： | 1 |
| 18 | Cell tropism of Staphylococcus aureus in bovine mammary gland cell cultures显示文摘 | Lammers A Nuijten P J M Kruijt E | 1999 | Vet Microbiol1999，67，： | 1 |
| 19 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model 显示文摘 | DELNOIJ E LAMMERS F A KUIPERS J A M | 1997 | Chemical Engineering Science1997，52，9： | 1 |
| 20 | XRD study of the new rigid-rod polymer fibre PIPD 显示文摘 | Klop E A Lammers M | 1998 | Polymer1998，39，24： | 1 |
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