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| 1 | Myofibroblastic cell activation and neovascularization predict native liver survival and development of esophageal varices in biliary atresia显示文摘AIM:To study the relation between collagen 1,α-smooth muscle actin(α-SMA)and CD34 expression and the most essential portoenterostomy(PE)outcomes.METHODS:Liver specimens were obtained at PE from33 biliary atresia(BA)patients for immunohistochemical analysis of collagen 1,α-SMA and CD34.Liver biopsies from 35 organ donors were used as controls.Expression patterns were related to clinical data including age at PE,serum total and conjugated bilirubin concentration at the time of PE and during follow-up,incidence of esophageal varices in follow-up upper gastrointestinal endoscopies,and native liver survival as well as to detailed histopathological findings.RESULTS:Collagen 1(16.4%vs 4.5%,P<0.0001),α-SMA(17.9%vs 4.6%,P<0.0001)and CD34(4.9%vs 3.8%,P=0.017)were markedly overexpressed in BA patients compared with controls.Patients who underwent liver transplantation by age of two years had significantly higher expression of collagen 1(18.6%vs 13.7%,P=0.024),α-SMA(20.4%vs 15.4%,P=0.009)and CD34(5.9%vs 4.0%,P=0.029)at PE compared with native liver survivors.CD34-positive microvessels were identified in the centrizonal region close to central vein in every BA patient.In majority of BA cases(56%)neovascularization was frequent as CD34-positive microvessels were observed in over half of the hepatic lobules.In controls,the CD34-positive microvessels were rare as they were completely absent in 40%and were found in less than 5%of the hepatic lobules in the rest.The difference between BA patients and controls was significant(P<0.0001).Patients who developed esophageal varices by two years had significantly higher expression of CD34 at PE compared with patients without varices(5.6%vs 4.0%,P=0.019).Expression ofα-SMA(r=0.758,P<0.0001)and collagen 1(r=0.474,P=0.016),and the amount of CD34-positive microvessels(r=0.356,P=0.047)were related to patient age at PE.CONCLUSION:Hepatic myofibroblastic cell activation,fibrogenesis and neovascularization are enhanced in BA,progress with increasing PE age and relate to native liver survival and development of esophageal varices. | Janne S Suominen Hanna Lampela Pivi Heikkil Jouko Lohi Hannu Jalanko Mikko P Pakarinen | 2014 | World Journal of Gastroenterology2014，20，12： | 6 |
| 2 | Transfer of elonidine and dexmedetomidine across the isolated perfused hu- man placenta 显示文摘 | Ala-Kokko TI Pienimaki P Lampela E | 1997 | A cta Anaesthesiol Scand1997，41，2： | 1 |
| 3 | Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection 显示文摘 | LAMPELA P SOININEN P PUTTONEN K A | 2004 | Int J Pharm2004，284，12： | 1 |
| 4 | Different synergistic roles of small polyethylenimine and Dosper in gene delivery显示文摘 | LAMPELA P ELOMAA M RUPONEN M | 2003 | J Controlled Release2003，88，1： | 1 |
| 5 | Effect of cell-surface glycosaminoglycans on cationic cartier combined with low-MW PEI mediated gene transfection显示文摘 | LAMPELA P SOININEN P PUTTONEN K A | 2004 | International Journal of Pharmaceutics2004，284，12： | 1 |
| 6 | High hospital burden in overlap syndrome of asthma and COPD 显示文摘 | Anderse n H Lampela P Nevanlinna A | 2013 | Clin Respir J2013，7，4： | 1 |
| 7 | High hospital burden in overlap syndrome of asthma and COPD显示文摘 | Andersen H Lampela P Nevanlinna A | 2013 | Clin Respir J2013，7，4： | 1 |
| 8 | Transfer of elonidine and dexmedetomidine across the isolated perfused human placenta显示文摘 | Ala-Kokko T I Pienima P Lampela E | 1997 | Acta Anaesthesiol Stand1997，41，1： | 1 |
| 9 | Transfer of clonidine and dexmedetonfidine aeioss the isolated pefused hunmn plaeenta 显示文摘 | Aija Kokko T I Pienimaki P Lampela E | 1997 | Acta Anaesthesiol Scand1997，41，2： | 1 |
| 10 | Different synergistic roles of small polyethylenimine and Dosper in gene delivery 显示文摘 | Lampela P Elomaa M Ruponen M | 2003 | J Controlled Release2003，88，： | 1 |
| 11 | Native liver histology after successful portoenterostomy in biliary atresia显示文摘 | Lampela H Kosola S Heikkil P | 2014 | J Clin Gastroenterol2014，48，8： | 1 |
| 12 | The Role of PEI Structure and Size in the PEVLiposome-Mediated Synergism of Gene Transfection 显示文摘 | Hanzlikova M Soininen P Lampela P | 2009 | Plasmid2009，61，1： | 1 |
| 13 | The Use of Low- Molecular-Weight PEIs as Gene Carriers in the Monkey Fibroblastoma and Rabbit Smooth Muscle Cell Cultures 显示文摘 | Lampela P Raisanen J Mannisto P T | 2002 | The Journal of Gene Medicine2002，4，2： | 1 |
| 14 | High hos- pital burden in overlap syndrome of asthma and COPD 显示文摘 | Andersen H Lampela P Nevanlinna A | 2013 | Clin Respir J2013，7，4： | 1 |
| 15 | Transfer of clonidine and dexmedetonddine across the isolated perfused hun placenta显示文摘 | ALA KOKKO T I PIENIMAKI P LAMPELA E | 1997 | Acta AJmesthesiol Scand1997，41，2： | 1 |
| 16 | Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures显示文摘 | Lampela P Huotari M Harjula A | 2003 | Plasmid2003，50，3： | 1 |
| 17 | Transfer of elonidine and dexmedetomidine across the isolated per'fused human placenta显示文摘 | Ala-Kokko TI Pienimki P Lampela E | 1997 | Acta Anaesthesiol Scand1997，41，2： | 1 |
| 18 | Native liver histology after successful portoenterostomy in biliary atresia显示文摘 | Lampela H Kasola S Heikkild P | 2013 | J Clin Gastroenterol2013，36，9： | 1 |
| 19 | Effects of medication assessment as part of a comprehensive geriatric assessment on drug use over a 1-year period: a population- based intervention study 显示文摘 | Lampela P Hartikainen S Lavikainen P | 2010 | 507-521 Drugs Aging2010，27，6： | 1 |
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