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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | ImmunostimulatoryRNA oligonucleotides induce an effective antitumoral NK cellresponse through the TLR7显示文摘 | Bourquin C Schmidt L Lanz A L | 2009 | J Immunol2009，183，3： | 1 |
| 3 | Receptor modeling of C2-C7 hydrocarbon sources at an urban background site in Zurich, Switzerland : Changes between 1993-1994 and 2005-2006显示文摘 | Lanz V A Hueglin C Buchmann B | 2008 | Atmos Chem Phys2008，8，： | 1 |
| 4 | Evaluation and optimization of capillary zone electrophoresis with different dynamic capillary coatings for the determination of carbohydrate-deficient transferrin in human serum显示文摘 | Kuhn M Bortolotti F | 2002 | J Chromatogr A2002，979，： | 1 |
| 5 | The γ-secretase inhibitor N--S-pbenylglycine t-butyl ester reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young ( plaque-free ) and aged ( plaque-bearing ) Tg2576 mice 显示文摘 | LANZ T A HIMES C S PALLANTE G | 2003 | J Pharmacol Exp Ther2003，305，3： | 1 |
| 6 | Bilateral paramedian'pontine base infarction显示文摘 | Lanz S Dutseh M Raneh C | 2006 | Stroke2006，15，： | 1 |
| 7 | Radiation Metabolomics Biomarker Discovery in the Urine of Gam-ma-Irradiated Rats Using a Simplified Metabolomics Proto-col of Gas Chromat Graphy-Mass Spectrometry Combined withRandom Forests Machine Learningalgorithm显示文摘 | Lanz C Patterson A D Slavik J et a1 | | 0，，02： | 1 |
| 8 | Schistosoma mansoni: immunodiagnosis is improved by sodium metaperiodate which reduces cross-reactivity due to glycosylated epitopes of solu- ble egg antigen 显示文摘 | Alarcon de Noya B Colmenares C Lanz H | 2000 | Exp Parasitol2000，95，2： | 1 |
| 9 | Evaluation and optimization of capillary zone electrophoresis with different dynamic capillary coatings for the determination of carbohydrate-deficient transferrin in human serum显示文摘 | Lanz C Kuhn M Bortolotti F | 2002 | J Chromatogr A2002，979，12： | 1 |
| 10 | Rapid determination of gemcitabine in plasma and serum using reversed-phase HPLC显示文摘 | Lanz C Fruh M Thormann W | 2007 | J Sep Sci2007，30，12： | 1 |
| 11 | Angiotensinogen M235T polymorphism is associated with coronary artery disease severity 显示文摘 | LANZ J R PEREIRA A C LEMOS P A | 2005 | Clin Chim Acta2005，362，： | 1 |
| 12 | Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit Influenza A Virus Replication显示文摘 | Lanz C Yángüez E Andenmatten D Stertz S | 2015 | J Virol2015，89，1： | 1 |
| 13 | Capillary zone electrophoresis with a dynamic double coating for analysis of carbohydratedeficient transferrin in human serum:Impact of resolution between disialo- and trisialotransferrin on reference limits显示文摘 | Thormann W | 2003 | Electrophoresis2003，24，： | 1 |
| 14 | Age Determinations of Main-sequence Stars: Combining Different Methods 显示文摘 | LACHAUMEL R DOMINIK C LANZ T | 1999 | A&AS1999，348，： | 1 |
| 15 | Accurate determination of microbial diversity from 454pyrosequencing data显示文摘 | Quince C Lanzén A Curtis TP | | 0，，09： | 1 |
| 16 | Improved capillary electrophoresis method for the determination ofcarbohydrate-deficient transferrin in patient sera显示文摘 | Lanz C Kuhn M Deiss V | 2004 | Electrophoresis2004，25，14： | 1 |
| 17 | Bilateral paramedian pontine base infarction显示文摘 | Lanz S Dutsch M Rauch C | 2006 | Stroke2006，15，： | 1 |
| 18 | Comparing eye movements recorded by search coil and infrared eye tracking 显示文摘 | Schmitt KU Muser MH Lanz C | 2007 | Journal of Clinical Monitoring and Computing2007，21，1： | 1 |
| 19 | Schistosoma mansoni:Immunodiagnosis is improved by Sodium Metaperiodate which reduces cross-reactivity due to glycosylated epitopes of soluble egg antigen显示文摘 | De Noya BA Colmenares C Lanz H | 2000 | ExpParasitol2000，95，： | 1 |
| 20 | Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK cell response through the TLR7显示文摘 | Bourquin C Schmidt L Lanz AL | 2009 | J Immunol2009，183，10： | 1 |
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