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| 1 | 儿童和成人住院期间心脏骤停时首次确诊的心脏节律与临床结局显示文摘Context: Cardiac arrests in adults are often due to ventricular fibrillation(VF) or pulseless ventricular tachycardia(VT), which are associated with better outcomes than asystole or pulseless electrical activity(PEA). Cardiac arrests in children are typically asystole or PEA. Objective: To test the hypothesis that children have relatively fewer in-hospital cardiac arrests associated with VF or pulseless VT compared with adults and, therefore, worse survival outcomes. Design, Setting, and Patients: A prospective observational study from a multicenter registry(National Registry of Cardiopulmonary Resuscitation) of cardiac arrests in 253 US and Canadian hospitals between January 1, 2000, and March 30, 2004. A total of 36 902 adults(≥ 18 years) and 880 children(<18 years) with pulseless cardiac arrests requiring chest compressions, defibrillation, or both were assessed. Cardiac arrests occurring in the delivery department, neonatal intensive care unit, and in the out-of-hospital setting were excluded. Main Outcome Measure: Survival to hospital discharge. Results: The rate of survival to hospital discharge following pulseless cardiac arrest was higher in children than adults(27% [236/880] vs 18% [6485/36 902]; adjusted odds ratio[OR], 2.29; 95% confidence interval[CI], 1.95- 2.68). Of these survivors, 65% (154/236) of children and 73% (4737/6485) of adults had good neurological outcome. The prevalence of VF or pulseless VT as the first documented pulseless rhythm was 14% (120/880) in children and 23% (8361/36 902) in adults(OR, 0.54; 95% CI, 0.44- 0.65; P<.001). The prevalence of asystole was 40% (350) in children and 35% (13 024) in adults(OR, 1.20; 95% CI, 1.10- 1.40; P=.006), whereas the prevalence of PEA was 24% (213) in children and 32% (11 963) in adults(OR, 0.67; 95% CI, 0.57- 0.78; P< .001). After adjustment for differences in preexisting conditions, interventions in place at time of arrest, witnessed and/or monitored status, time to defibrillation of VF or pulseless VT, intensive care unit location of arrest, and duration of cardiopulmonary resuscitation, only first documented pulseless arrest rhythm remained significantly associated with differential survival to discharge(24% [135/563] in children vs 11% [2719/24 987] in adults with asystole and PEA; adjusted OR, 2.73; 95% CI, 2.23- 3.32). Conclusions: In this multicenter registry of in-hospital cardiac arrest, the first documented pulseless arrest rhythm was typically asystole or PEA in both children and adults. Because of better survival after asystole and PEA, children had better outcomes than adults despite fewer cardiac arrests due to VF or pulseless VT. | Nadkarni V. M Larkin G. L Peberdy M. A 刘宇(译) 马超(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 2 |
| 2 | Analysis of genes involved in methyl halide degradation in Aminobacter lissarensis CC495显示文摘 | WARNER K L LARKIN M J HARPER D B | 2005 | FEMS Microbiology Letters2005，251，1： | 1 |
| 3 | Effects of aerobic exercise training on the protein kinase B (PKB)/mammalian target of rapamyein (roTOR) signaling pathway in aged skeletal muscle显示文摘 | Reynolds T H 4th Reid P Larkin L M | 2004 | Exp Gerontol2004，39，3： | 1 |
| 4 | Phospholipase activation triggers apoptosis in photosensitizer,mouse,lymphoma cells显示文摘 | AGARWAL M L LARKIN H E ZAIDI S I | 1993 | Cancer Res1993，53，： | 1 |
| 5 | First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults显示文摘 | Nadkarni V M Larkin G L Peberdy M A | 2006 | JAMA2006，295，1： | 1 |
| 6 | Phospholipase activation triggers apoptosis in photosensitized lyrnphoma cells显示文摘 | Agarwal M L Larkin H E Zaidi S I A | 1993 | Cancer Res1993，53，11： | 1 |
| 7 | Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replication system显示文摘 | Larkin J Jin L Farmen M | 2003 | Inter Cytokine Res2003，23，5： | 1 |
| 8 | Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray显示文摘 | Larkin P Folmar L C Hemmer M J | 2003 | Environmental Health Perspective2003，111，： | 1 |
| 9 | Phosphine adducts of monomeric zinc (bis-phenoxides) solution and solide state structures of (2,6-di-tert-butylphenoxide)ZnL complexes(L=PMePh2 and PCy3)显示文摘 | DARENSBOURG D J ZIMMER M S RAINEY P LARKINS D L | 1998 | Inorg Chem1998，37，： | 1 |
| 10 | HAZID, a computer aid for hazard identification ( Ⅰ ) : The STOPHAZ package and the HAZID code: an overview, the issues and the structure 显示文摘 | McCoy S A Wakeman S J Larkin F D Jefferson M L Chung P W H Rushton A G Lees F P Heino P | 1999 | Process and Environmental Protection1999，77，6： | 1 |
| 11 | Biodegradation and Rhodococcus-masters of catabolic versatility显示文摘 | Larkin M J Kulakov L A A1len C C 2005 | 2005 | Curr Opin Biotechnol2005，16，： | 1 |
| 12 | Health-related quality of life and sleep-disordered breathingin children显示文摘 | ROSEN C L PALERMO T M LARKIN E K | 2002 | Sleep2002，25，6： | 1 |
| 13 | Biological deterioration of wood-base composite panels显示文摘 | Laks P E Richter D L Larkin G M | 2000 | Wood Design Focus2000，11，4： | 1 |
| 14 | T-helper 17 cells are associ- ated with pathology in human schistosomiasis 显示文摘 | Mbow M Larkin BM Meurs L | 2013 | J Infect Dis2013，207，1： | 1 |
| 15 | Repeated bouts of aerobic exercise lead to reductions in skeletal muscle free radical generation and nuclear factor kappa B activition显示文摘 | Brooks S V Vasilaki A Larkin L M | 2008 | J Physiol2008，586，16： | 1 |
| 16 | Zinc uptake into MCF-10 A cells is inhibited by cholesterol depletion显示文摘 | LARKIN J M BROWN M S GOLDSTEIN J L | 1983 | Cell1983，33，1： | 1 |
| 17 | 600 nm flash pumped dye laser for fragile telangiectasia of the elderly显示文摘 | Goldman L Kerr JH Larkin M | 1993 | Lasers Surg Med1993，13，2： | 1 |
| 18 | Health-related quality of Life and sleep-disordered breathing in children显示文摘 | Rosen C L Palermo T M Larkin E K | 2002 | Sleep2002，25，6： | 1 |
| 19 | Transient Enhancement of GLUT4 Levels in Rat Epitrochlearis Muscle after Exercise Training显示文摘 | Reynolds T H Brozinick J T Larkin L M | 2000 | Appl Physiol2000，88，6： | 1 |
| 20 | A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates显示文摘 | Everts-van der Wind A Kata S R Band M R Rebeiz M Larkin D M Everts R E Green C A Liu L Natarajan S Goldammer T Lee J H McKay S Womack J E Lewin H A | 2004 | Genome Res2004，14，7： | 1 |
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