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| 1 | Probiotic supplementation decreases intestinal transit time: Meta-analysis of randomized controlled trials显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time (ITT) and to identify factors that influence these outcomes. METHODS: A systematic review of randomized controlled trials (RCTs) of probiotic supplementation that measured ITT in adults was conducted by searching MEDLINE and EMBASE using relevant combinations. Main search limits included RCTs of probiotic supplementation in healthy or constipated adults that measured ITT. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference (SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses were conducted to examine the impact of moderator variables on ITT SMD. RESULTS: A total of 11 clinical trials with 13 treatment effects representing 464 subjects were included in this analysis. Probiotic supplementation was associated with decreased ITT in relation to controls, with an SMD of 0.40 (95%CI: 0.20-0.59, P < 0.001). Constipation (r 2 = 39%, P = 0.01), higher mean age (r 2 = 27%, P = 0.03), and higher percentage of female subjects (r 2 = 23%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation and in older vs younger subjects [both SMD: 0.59 (95%CI: 0.39-0.79) vs 0.17 (95%CI: -0.08-0.42), P = 0.01]. Medium to large treatment effects were identified with Bifidobacterium Lactis (B. lactis ) HN019 (SMD: 0.72, 95%CI: 0.27-1.18, P < 0.01) and B. lactis DN-173 010 (SMD: 0.54, 95%CI: 0.15-0.94, P < 0.01) while other single strains and combination products yielded small treatment effects. CONCLUSION: Overall, short-term probiotic supplementation decreases ITT with consistently greater treatment effects identified in constipated or older adults and with certain probiotic strains. | Larry E Miller Arthur C Ouwehand | 2013 | World Journal of Gastroenterology2013，19，29： | 9 |
| 2 | Augmented reality assisted surgery: a urologic training tool显示文摘扩充现实广泛地在航空学被使用并且是在外科以内的一个发展中的概念。在这个预研项目,我们在古格尔·格拉斯 ® 上为使用开发了一个应用程序训练在怎么放可膨胀的阴茎修复术的泌尿学居民的光装头的显示。我们使用扩充的短语现实帮助了外科在外科的设置描述扩充现实的这个新奇应用程序。应用程序表明可膨胀的阴茎修复术放置的外科的过程的步。它也包含允许的软件用一个照相机的点从光装头的显示喂使教师能在阴茎修复术的放置期间与居民一起交往的兴趣的察觉。自愿参加学习的泌尿学受训练者和教师被给时间经历技术在起作用或 perioperative 背景并且要求完成反馈调查。从用 10 点规模的 30 个全部的参加者,教育实用性被评估 8.6,航行的容易被评估 7.6,到使用的可能性的被评估 7.4,并且在操作空间的分心被评估 4.9。当在受训练者和教师之间成层时,受训练者发现技术更教育有用,并且少些分散。总的来说, 81% 参加者在他们的住处程序想要这种技术,并且 93% 以后在操作房间里看见这种技术。这种技术的进一步的开发在完整的版本前被保证,并且进一步的研究是必要的更好描绘扩充现实的有效性在泌尿科的外科的训练的帮助外科。 | Ryan M Dickey Neel Srikishen Larry I Lipshultz Philippe E Spiess Rafael E Carrion Tariq S Hakky | 2016 | Asian Journal of Andrology2016，18，5： | 6 |
| 3 | Contemporary meta-analysis of short-term probiotic consumption on gastrointestinal transit显示文摘AIM: To determine the efficacy of probiotic supplementation on intestinal transit time(ITT) in adults and to identify factors that influence these outcomes. METHODS: We conducted a systematic review of randomized controlled trials of probiotic supplementation that measured ITT in adults. Study quality was assessed using the Jadad scale. A random effects meta-analysis was performed with standardized mean difference(SMD) of ITT between probiotic and control groups as the primary outcome. Meta-regression and subgroup analyses examined the impact of moderator variables on SMD of ITT.RESULTS: A total of 15 clinical trials with 17 treatment effects representing 675 subjects were included in this analysis. Probiotic supplementation was moderately efficacious in decreasing ITT compared to control, with an SMD of 0.38(95%CI: 0.23-0.53, P < 0.001). Subgroup analyses demonstrated statistically greater reductions in ITT with probiotics in subjects with vs without constipation(SMD: 0.57 vs 0.22, P < 0.01) and in studies with high vs low study quality(SMD: 0.45 vs 0.00, P = 0.01). Constipation(R^2 = 38%, P < 0.01), higher study quality(R^2 = 31%, P = 0.01), older age(R^2 = 27%, P = 0.02), higher percentage of female subjects(R^2 = 26%, P = 0.02), and fewer probiotic strains(R^2 = 20%, P < 0.05) were predictive of decreased ITT with probiotics in meta-regression. Medium to large treatment effects were identified with B. lactis HN019(SMD: 0.67, P < 0.001) and B. lactis DN-173 010(SMD: 0.54, P < 0.01) while other probiotic strains yielded negligible reductions in ITT relative to control.CONCLUSION: Probiotic supplementation is moderately efficacious for reducing ITT in adults. Probiotics were most efficacious in constipated subjects, when evaluated in high-quality studies, and with certain probiotic strains. | Larry E Miller Angela K Zimmermann Arthur C Ouwehand | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 4 | PRIMARY CELL CULTURE FOR EMBRYONIC CARDIAC MYOCYTES OF MEXICAN AXOLOTL AND DISTRIBUTION OF DESMIN AND VIMENTIN显示文摘INTRODUCTIONTheaxolotlprovidesavaluablemodelsystemforstudyingmuscledevelopmentandfunction.Electronmicroscopyrevealsthataxolot... | Zhu Yongze, Robert W Zajdel *, Margaret E Fransen *, Larry F Lemanski *(Department of Anatomy, Medical College of Yangzhou University, Yangzhou, 225001 Chian Department of Anatomy and Cell Biology, State University of New York, Health Science Cent | 1999 | 中国组织化学与细胞化学杂志1999，8，1： | 2 |
| 5 | Epidemiology of environmental tobacco smoke exposure 显示文摘 | Ross C Brownson Larry W Figgs Laura E Caisley | 2002 | Oncogene2002，，21： | 1 |
| 6 | The ecology of medical care revisited显示文摘 | Larry A Green George E Fryer Jr Barbara P Yawn David lanier Susan M Dovey | 2001 | The New England Journal of Medicine2001，334，26： | 1 |
| 7 | Cyclic Flexural Testing of Concentrically Braced Frame Beam-Column Connections 显示文摘 | Christopher D Stoakes' Larry A Fahnestock P E | 2011 | Structural Engineering2011，137，7： | 1 |
| 8 | Rapid accumula- tion of γ-aminobutyric acid and alanine in soybean leaves in re- sponse to an abrupt transfer to lower temperature, darkness, or mechanical manipulation显示文摘 | Wallace W Jacob Secor Larry E Schrader | 1984 | Plant Physiol1984，75，1： | 1 |
| 9 | Relationships among Rat- ings, Production, Efficiency and the General Aptitude Test Battery Scales in an Industrial Setting 显示文摘 | Harry E Anderson S Larry R | 1973 | Journal of Ap- plied Psychology1973，，1： | 1 |
| 10 | The effects of land-uso history on soil properties and nutrient dynamics in northern hardwood forests of the ad- irondack mountains 显示文摘 | Larry E F Canham C D Marks P L | 2004 | Ecosystems2004，7，2： | 1 |
| 11 | A natural polymerbased cross-linker system for conformance gel systems显示文摘 | Reddy B R Larry E Dalrymple E | 2003 | SPE J2003，48，5： | 1 |
| 12 | Evolution and Revolution as Organizations Grow显示文摘 | Larry E Greiner | | 0，，07： | 1 |
| 13 | Nitrogen release during coal combustion显示文摘 | Larry L Baxter Reginald E Mitchell Thomas H Fletcher | 1996 | Energy and Fuels1996，10，1： | 1 |
| 14 | Tread compounds with highly-dispersible silica显示文摘 | Larry R E William C Fultz J M | 1998 | Rubb World1998，219，2： | 1 |
| 15 | Exposure to Phthalates and Breast Cancer Risk in Northern Mexico显示文摘 | López-Carrillo Lizbeth Hernández-Ramírez Raúl U Calafat Antonia M Torres-Sánchez Luisa Galván-Portillo Marcia Needham Larry L Ruiz-Ramos Rubén Cebrián Mariano E | 2010 | Environmental Health Perspectives2010，，4： | 1 |
| 16 | Rate and extent of digestion of the ethanol-soluble and neutral detergent-insoluble fractians of corn grain显示文摘 | A lice N Pell Larry E Chase | 1999 | J Anim Sci1999，77，： | 1 |
| 17 | The specificity of Proanthocyanidin-pro-tein interactions显示文摘 | Ann E Hagerman Larry G Butler | 1981 | J Biological Chem1981，266，9： | 1 |
| 18 | A breastfeeding curriculum for residents and medical students:a multidisciplinary ap- proach显示文摘 | Tony O Eve E Larry L | 2005 | J Human Laet2005，21，4： | 1 |
| 19 | MER-DIMES: A planetary landing application of computer vision 显示文摘 | Yang Cheng Johnson A E Larry Matthies | 1999 | IEEE Transactions on Aerospace and Electronic Systems1999，，： | 1 |
| 20 | Overview of the fundamental reactions and degradation mechanisms of NOx storage/reduction catalysts 显示文摘 | William S Epling Larry E Campbell Aleksey Yezerets | 2004 | Catalysis Reviews2004，46，2： | 1 |
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