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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | 2017欧洲心脏病学会/欧洲心胸外科协会心脏瓣膜病管理指南中经导管主动脉瓣置换术相关更新解读显示文摘自2012欧洲心脏协会/欧洲心胸外科协会关于心脏瓣膜病的管理指南发布以来,新的临床证据又大量积累。这些新证据使欧洲心脏协会/欧洲心胸外科协会需要更新瓣膜病的管理指南以达到心内科与心外科医师间的共识。该文将从经导管主动脉瓣置换术出发,解读2017年新指南所作出的更新。 | Tasalak Thonghong Manik Chopra Ole De Backer Lars Sndergaard 王玺 | 2018 | 华西医学2018，33，2： | 12 |
| 4 | The treatment of Parkinson's disease with deep brain stimulation: current issues显示文摘Deep brain stimulation has become a well-established symptomatic treatment for Parkinson's disease during the last 25 years. Besides improving motor symptoms and long-term motor complications, positive effects on patients' mobility, activities of daily living, emotional well-being and health-related quality of life have been recognized. Apart from that, numerous clinical trials analyzed effects on non-motor symptoms and side effects of deep brain stimulation. Several technical issues and stimulation paradigms have been and are still being developed to optimize the therapeutic effects, minimize the side effects and facilitate handling. This review summarizes current therapeutic issues, i.e., patient and target selection, surgical procedure and programming paradigms. In addition it focuses on neuropsychological effects and side effects of deep brain stimulation. | Alexia-Sabine Moldovan Stefan Jun Groiss Saskia Elben Martin Südmeyer Alfons Schnitzler Lars Wojtecki | 2015 | Neural Regeneration Research2015，10，7： | 8 |
| 5 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet2012，，9853： | 5 |
| 6 | 高温环境中训练和比赛的共识性建议显示文摘高温环境中运动会引起体温调节和其它生理压力,继而可导致耐力运动能力的损害。本共识性声明的目的是提供最新的建议以使热环境中体育活动时的运动能力最优化。可用于降低热应激压力和优化运动能力的最重要干预方式是热习服,其应包括1~2周以上反复的运动—高温环境暴露。此外,运动员应在正常水合状态下开始比赛和训练,并将运动中的脱水最小化。随着商用降温系统(如降温背心)的发展,在高温环境中训练或比赛前,运动员可以采取降温策略来促进热的散发或提高蓄热能力。而且,赛事组织者应该设计大面积的遮阳区域,并提供降温和补水设施,按照最小化运动员的健康风险来安排赛事,尤其是在大众参与的赛事中及一年之中炎热天气开始之初。以最近的2008年奥运会和2014年国际足联世界杯为例,当比赛在高温环境中举行时,赛事主管机构应考虑在比赛中或比赛之间允许额外的(或更长的)恢复期以提供补水和降温的时机。 | Sébastien Racinais Juan-Manuel Alonso Aaron J.Coutts Andreas D.Flouris Olivier Girard José González -Alonso Christophe Hausswirth Ollie Jay Jason K.W.Lee Nigel Mitchell George P.Nassis Lars Nybo Babette M.Pluim Bart Roelands Michael N.Sawka Jonathan Wingo Julien D.Périard. 徐金成 高璨 赵杰修 | 2016 | 中国运动医学杂志2016，35，2： | 4 |
| 7 | User Driven Innovation in the Building Process显示文摘During the late years there has been an ever-increasing focus on the possibilities to change the building process to raise quality on the final building products as well as the activities of actors involved in the building process. One reason for this interest is the new opportunities evolving due to introduction of advanced information and communication technology (ICT). The paper focuses on creative changes of the building process powered by user driven innovation activities. An overview of existing user driven innovation methodologies is given as well experiences from the ongoing Virtual Innovation in Construction (VIC) project. One important driving force for change is the opportunity for users to develop and articulate real needs concerning for example different functionalities of a building and its parts, but also on artifacts supporting the actual needs capture and requirements formulation during building design. A general methodological framework and meta ontology for Virtual Innovation in Construction is presented as well as findings from implementation of the method. | Per Christiansson Kistian Birch Sφrensen Mette Rφdtness Mette Abrahamsen Lars Ostenfeld Riemnann Morten Alsdorf | 2008 | Tsinghua Science and Technology2008，13，S1： | 4 |
| 8 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | 2012 (9853)2012，，9853： | 3 |
| 9 | Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse显示文摘AIM: To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (HPE). METHODS: The stomachs of isourane-anesthetized mice were exteriorized, and the mucosal surface exposed. Blood flow was measured with the laser-Doppler technique, and systemic arterial blood pressure monitored. C57BL/6 mice were exposed to water extract produced from H pylori strain 88-23. To investigate the role of a nerveor iNOS-mediated pathway, we used intraluminal lidocaine and iNOS-/-mice. Blood flow response to the endogenous nitric oxide synthase inhibitor asymmetric dimethyl arginine (ADMA) was also assessed. RESULTS: In wild-type mice, HPE decreased mucosal blood flow by approximately 30%. This reduction was abolished in iNOS-defi cient mice, and by pre-treatment with lidocaine. Luminally applied ADMA resulted in reduction in blood flow similar to that observed in wild-type mice exposed to HPE. CONCLUSION: A H pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways. | Johanna Henriksns Christer Atuma Mia Phillipson Stellan Sandler Lars Engstrand Lena Holm | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 10 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet . 2012 (9853)2012，，： | 2 |
| 11 | On hash functions using checksums显示文摘 | Praveen Gauravaram John Kelsey Lars R. Knudsen S?ren S. Thomsen | 2010 | International Journal of Information Security2010，，2： | 2 |
| 12 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet2012，，9853： | 2 |
| 13 | N -fertilization and soil acidification effects on N2O CO2and CO2 emission from temperate pine forest soil 显示文摘 | Bishal K S Lars R B Gunnar A | 1995 | Soil BiolBiochem1995，27，11： | 1 |
| 14 | The polycomb-group protein MEDEA regulates seed development by controlling experssion of the MADS-box gene PHERES1显示文摘 | CLAUDIA K LARS H CHARLES S | 2003 | Genes and Development2003，17，： | 1 |
| 15 | Nitrogen loss from unpolluted South American forestsmainly via dis- solved organic compounds 显示文摘 | Steven S Perakis Lars O | 2002 | Nature2002，415，24： | 1 |
| 16 | Leydig cell death in rats exposed to bismuth subnitrate显示文摘 | Lars H P Meredin S Erik E | 2003 | Journal of Applied Toxicology2003，23，4： | 1 |
| 17 | Reaction network in the catalytic vapor-phase oxidation of toluene and xylenes显示文摘 | Andersson S Lars T | 1988 | J Catal1988，98，： | 1 |
| 18 | Correlation between pectate lyase activity and ability of diazotrophic Klebsiella oxytoca VN 13 to penetrate into plant tissues 显示文摘 | Kovtunovych G Lar O Kamalova S Kordyum V Kleiner D Kozyrovska N | 1999 | Plant Soil1999，215，1： | 1 |
| 19 | Ulcerative colitis显示文摘 | Ingrid Ordás Lars Eckmann Mark Talamini Daniel C Baumgart William J Sandborn | 2012 | The Lancet2012，，9853： | 1 |
| 20 | Prevalence of aspirin resistance in patients with an evolving acute myocardial infarction 显示文摘 | TIna S Bo J Lars K | 2007 | Thromb Res2007，119，5： | 1 |
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